Association of optimal time interval to re-resection for incidental gallbladder cancer with overall survival

A multi-institution analysis from the us extrahepatic biliary malignancy consortium

Cecilia G. Ethun, Lauren M. Postlewait, Nina Le, Timothy M. Pawlik, Stefan Buettner, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A. Isom, Ryan C. Fields, Linda X. Jin, Sharon M. Weber, Ahmed Salem, Robert C G Martin, Charles Scoggins, Perry Shen, Harveshp D. Mogal, Carl Schmidt, Eliza Beal, Ioannis Hatzaras & 3 others Rivfka Shenoy, David A. Kooby, Shishir K. Maithel

Research output: Contribution to journalArticle

Abstract

Importance: The current recommendation is to perform re-resection for select patients with incidentally discovered gallbladder cancer. The optimal time interval for re-resection for both patient selection and long-term survival is not known. Objective: To assess the association of time interval from the initial cholecystectomy to reoperation with overall survival. Design, Setting, and Participants: This cohort studywas conducted from January 1, 2000, to December 31, 2014 at 10 US academic institutions. A total of 207 patients with incidentally discovered gallbladder cancer who underwent reoperation and had available data on the date of their initial cholecystectomy were included. Exposures: Time interval from the initial cholecystectomy to reoperation: group A: less than 4 weeks; group B: 4 to 8 weeks; and group C: greater than 8 weeks. Main Outcomes and Measures: Primary outcomewas overall survival. Results: Of 449 patients with gallbladder cancer, 207 cases (46%) were discovered incidentally and underwent reoperation at 3 different time intervals from the date of the original cholecystectomy: group A: less than 4 weeks (25 patients, 12%); B: 4 to 8 weeks (91 patients, 44%); C: more than 8 weeks (91 patients, 44%). The mean (SD) ages of patients in groups A, B, and C were 65 (9), 64 (11), and 66 (12) years, respectively. All groups were similar for baseline demographics, extent of resection, presence of residual disease, T stage, resection margin status, lymph node involvement, and postoperative complications. Patients who underwent reoperation between 4 and 8 weeks had the longest median overall survival (group B: 40.4 months) compared with those who underwent early (group A: 17.4 months) or late (group C: 22.4 months) reoperation (log-rank P = .03). Group A and C time intervals (vs group B), presence of residual disease, an R2 resection, advanced T stage, and lymph node involvement were associated with decreased overall survival on univariable Cox regression. Only group A (hazard ratio, 2.63; 95%CI, 1.25-5.54) and group C (hazard ratio, 2.07; 95%CI, 1.17-3.66) time intervals (vs group B), R2 resection (hazard ratio, 2.69; 95%CI, 1.27-5.69), and advanced Tstage (hazard ratio, 1.85; 95%CI, 1.11-3.08) persisted on multivariable Cox regression analysis. Conclusions and Relevance: The optimal time interval for re-resection for incidentally discovered gallbladder cancer appears to be between 4 and 8 weeks after the initial cholecystectomy.

Original languageEnglish (US)
Pages (from-to)143-149
Number of pages7
JournalJAMA Surgery
Volume152
Issue number2
DOIs
StatePublished - Feb 1 2017

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Gallbladder Neoplasms
Reoperation
Cholecystectomy
Survival
Neoplasms
Lymph Nodes
Patient Selection
Regression Analysis
Demography
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Surgery

Cite this

Association of optimal time interval to re-resection for incidental gallbladder cancer with overall survival : A multi-institution analysis from the us extrahepatic biliary malignancy consortium. / Ethun, Cecilia G.; Postlewait, Lauren M.; Le, Nina; Pawlik, Timothy M.; Buettner, Stefan; Poultsides, George; Tran, Thuy; Idrees, Kamran; Isom, Chelsea A.; Fields, Ryan C.; Jin, Linda X.; Weber, Sharon M.; Salem, Ahmed; Martin, Robert C G; Scoggins, Charles; Shen, Perry; Mogal, Harveshp D.; Schmidt, Carl; Beal, Eliza; Hatzaras, Ioannis; Shenoy, Rivfka; Kooby, David A.; Maithel, Shishir K.

In: JAMA Surgery, Vol. 152, No. 2, 01.02.2017, p. 143-149.

Research output: Contribution to journalArticle

Ethun, CG, Postlewait, LM, Le, N, Pawlik, TM, Buettner, S, Poultsides, G, Tran, T, Idrees, K, Isom, CA, Fields, RC, Jin, LX, Weber, SM, Salem, A, Martin, RCG, Scoggins, C, Shen, P, Mogal, HD, Schmidt, C, Beal, E, Hatzaras, I, Shenoy, R, Kooby, DA & Maithel, SK 2017, 'Association of optimal time interval to re-resection for incidental gallbladder cancer with overall survival: A multi-institution analysis from the us extrahepatic biliary malignancy consortium', JAMA Surgery, vol. 152, no. 2, pp. 143-149. https://doi.org/10.1001/jamasurg.2016.3642
Ethun, Cecilia G. ; Postlewait, Lauren M. ; Le, Nina ; Pawlik, Timothy M. ; Buettner, Stefan ; Poultsides, George ; Tran, Thuy ; Idrees, Kamran ; Isom, Chelsea A. ; Fields, Ryan C. ; Jin, Linda X. ; Weber, Sharon M. ; Salem, Ahmed ; Martin, Robert C G ; Scoggins, Charles ; Shen, Perry ; Mogal, Harveshp D. ; Schmidt, Carl ; Beal, Eliza ; Hatzaras, Ioannis ; Shenoy, Rivfka ; Kooby, David A. ; Maithel, Shishir K. / Association of optimal time interval to re-resection for incidental gallbladder cancer with overall survival : A multi-institution analysis from the us extrahepatic biliary malignancy consortium. In: JAMA Surgery. 2017 ; Vol. 152, No. 2. pp. 143-149.
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abstract = "Importance: The current recommendation is to perform re-resection for select patients with incidentally discovered gallbladder cancer. The optimal time interval for re-resection for both patient selection and long-term survival is not known. Objective: To assess the association of time interval from the initial cholecystectomy to reoperation with overall survival. Design, Setting, and Participants: This cohort studywas conducted from January 1, 2000, to December 31, 2014 at 10 US academic institutions. A total of 207 patients with incidentally discovered gallbladder cancer who underwent reoperation and had available data on the date of their initial cholecystectomy were included. Exposures: Time interval from the initial cholecystectomy to reoperation: group A: less than 4 weeks; group B: 4 to 8 weeks; and group C: greater than 8 weeks. Main Outcomes and Measures: Primary outcomewas overall survival. Results: Of 449 patients with gallbladder cancer, 207 cases (46{\%}) were discovered incidentally and underwent reoperation at 3 different time intervals from the date of the original cholecystectomy: group A: less than 4 weeks (25 patients, 12{\%}); B: 4 to 8 weeks (91 patients, 44{\%}); C: more than 8 weeks (91 patients, 44{\%}). The mean (SD) ages of patients in groups A, B, and C were 65 (9), 64 (11), and 66 (12) years, respectively. All groups were similar for baseline demographics, extent of resection, presence of residual disease, T stage, resection margin status, lymph node involvement, and postoperative complications. Patients who underwent reoperation between 4 and 8 weeks had the longest median overall survival (group B: 40.4 months) compared with those who underwent early (group A: 17.4 months) or late (group C: 22.4 months) reoperation (log-rank P = .03). Group A and C time intervals (vs group B), presence of residual disease, an R2 resection, advanced T stage, and lymph node involvement were associated with decreased overall survival on univariable Cox regression. Only group A (hazard ratio, 2.63; 95{\%}CI, 1.25-5.54) and group C (hazard ratio, 2.07; 95{\%}CI, 1.17-3.66) time intervals (vs group B), R2 resection (hazard ratio, 2.69; 95{\%}CI, 1.27-5.69), and advanced Tstage (hazard ratio, 1.85; 95{\%}CI, 1.11-3.08) persisted on multivariable Cox regression analysis. Conclusions and Relevance: The optimal time interval for re-resection for incidentally discovered gallbladder cancer appears to be between 4 and 8 weeks after the initial cholecystectomy.",
author = "Ethun, {Cecilia G.} and Postlewait, {Lauren M.} and Nina Le and Pawlik, {Timothy M.} and Stefan Buettner and George Poultsides and Thuy Tran and Kamran Idrees and Isom, {Chelsea A.} and Fields, {Ryan C.} and Jin, {Linda X.} and Weber, {Sharon M.} and Ahmed Salem and Martin, {Robert C G} and Charles Scoggins and Perry Shen and Mogal, {Harveshp D.} and Carl Schmidt and Eliza Beal and Ioannis Hatzaras and Rivfka Shenoy and Kooby, {David A.} and Maithel, {Shishir K.}",
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TY - JOUR

T1 - Association of optimal time interval to re-resection for incidental gallbladder cancer with overall survival

T2 - A multi-institution analysis from the us extrahepatic biliary malignancy consortium

AU - Ethun, Cecilia G.

AU - Postlewait, Lauren M.

AU - Le, Nina

AU - Pawlik, Timothy M.

AU - Buettner, Stefan

AU - Poultsides, George

AU - Tran, Thuy

AU - Idrees, Kamran

AU - Isom, Chelsea A.

AU - Fields, Ryan C.

AU - Jin, Linda X.

AU - Weber, Sharon M.

AU - Salem, Ahmed

AU - Martin, Robert C G

AU - Scoggins, Charles

AU - Shen, Perry

AU - Mogal, Harveshp D.

AU - Schmidt, Carl

AU - Beal, Eliza

AU - Hatzaras, Ioannis

AU - Shenoy, Rivfka

AU - Kooby, David A.

AU - Maithel, Shishir K.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Importance: The current recommendation is to perform re-resection for select patients with incidentally discovered gallbladder cancer. The optimal time interval for re-resection for both patient selection and long-term survival is not known. Objective: To assess the association of time interval from the initial cholecystectomy to reoperation with overall survival. Design, Setting, and Participants: This cohort studywas conducted from January 1, 2000, to December 31, 2014 at 10 US academic institutions. A total of 207 patients with incidentally discovered gallbladder cancer who underwent reoperation and had available data on the date of their initial cholecystectomy were included. Exposures: Time interval from the initial cholecystectomy to reoperation: group A: less than 4 weeks; group B: 4 to 8 weeks; and group C: greater than 8 weeks. Main Outcomes and Measures: Primary outcomewas overall survival. Results: Of 449 patients with gallbladder cancer, 207 cases (46%) were discovered incidentally and underwent reoperation at 3 different time intervals from the date of the original cholecystectomy: group A: less than 4 weeks (25 patients, 12%); B: 4 to 8 weeks (91 patients, 44%); C: more than 8 weeks (91 patients, 44%). The mean (SD) ages of patients in groups A, B, and C were 65 (9), 64 (11), and 66 (12) years, respectively. All groups were similar for baseline demographics, extent of resection, presence of residual disease, T stage, resection margin status, lymph node involvement, and postoperative complications. Patients who underwent reoperation between 4 and 8 weeks had the longest median overall survival (group B: 40.4 months) compared with those who underwent early (group A: 17.4 months) or late (group C: 22.4 months) reoperation (log-rank P = .03). Group A and C time intervals (vs group B), presence of residual disease, an R2 resection, advanced T stage, and lymph node involvement were associated with decreased overall survival on univariable Cox regression. Only group A (hazard ratio, 2.63; 95%CI, 1.25-5.54) and group C (hazard ratio, 2.07; 95%CI, 1.17-3.66) time intervals (vs group B), R2 resection (hazard ratio, 2.69; 95%CI, 1.27-5.69), and advanced Tstage (hazard ratio, 1.85; 95%CI, 1.11-3.08) persisted on multivariable Cox regression analysis. Conclusions and Relevance: The optimal time interval for re-resection for incidentally discovered gallbladder cancer appears to be between 4 and 8 weeks after the initial cholecystectomy.

AB - Importance: The current recommendation is to perform re-resection for select patients with incidentally discovered gallbladder cancer. The optimal time interval for re-resection for both patient selection and long-term survival is not known. Objective: To assess the association of time interval from the initial cholecystectomy to reoperation with overall survival. Design, Setting, and Participants: This cohort studywas conducted from January 1, 2000, to December 31, 2014 at 10 US academic institutions. A total of 207 patients with incidentally discovered gallbladder cancer who underwent reoperation and had available data on the date of their initial cholecystectomy were included. Exposures: Time interval from the initial cholecystectomy to reoperation: group A: less than 4 weeks; group B: 4 to 8 weeks; and group C: greater than 8 weeks. Main Outcomes and Measures: Primary outcomewas overall survival. Results: Of 449 patients with gallbladder cancer, 207 cases (46%) were discovered incidentally and underwent reoperation at 3 different time intervals from the date of the original cholecystectomy: group A: less than 4 weeks (25 patients, 12%); B: 4 to 8 weeks (91 patients, 44%); C: more than 8 weeks (91 patients, 44%). The mean (SD) ages of patients in groups A, B, and C were 65 (9), 64 (11), and 66 (12) years, respectively. All groups were similar for baseline demographics, extent of resection, presence of residual disease, T stage, resection margin status, lymph node involvement, and postoperative complications. Patients who underwent reoperation between 4 and 8 weeks had the longest median overall survival (group B: 40.4 months) compared with those who underwent early (group A: 17.4 months) or late (group C: 22.4 months) reoperation (log-rank P = .03). Group A and C time intervals (vs group B), presence of residual disease, an R2 resection, advanced T stage, and lymph node involvement were associated with decreased overall survival on univariable Cox regression. Only group A (hazard ratio, 2.63; 95%CI, 1.25-5.54) and group C (hazard ratio, 2.07; 95%CI, 1.17-3.66) time intervals (vs group B), R2 resection (hazard ratio, 2.69; 95%CI, 1.27-5.69), and advanced Tstage (hazard ratio, 1.85; 95%CI, 1.11-3.08) persisted on multivariable Cox regression analysis. Conclusions and Relevance: The optimal time interval for re-resection for incidentally discovered gallbladder cancer appears to be between 4 and 8 weeks after the initial cholecystectomy.

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