Association of novel measures of sleep disturbances with blood pressure: The Multi-Ethnic Study of Atherosclerosis

John S. Kim, Ali Azarbarzin, Rui Wang, Ina E. Djonlagic, Naresh M. Punjabi, Phyllis C. Zee, Brian B. Koo, Elsayed Z. Soliman, Magdy Younes, Susan Redline

Research output: Contribution to journalArticlepeer-review

Abstract

Background Mechanisms underlying blood pressure (BP) changes in obstructive sleep apnoea (OSA) are incompletely understood. We assessed the associations between BP and selected polysomnography (PSG) traits: sleep depth, airflow limitation measurements and OSA-specific hypoxic burden. Methods This cross-sectional analysis included 2055 participants from the Multi-Ethnic Study of Atherosclerosis who underwent PSG and BP measurements in 2010-2013. Sleep depth was assessed using the â € OR product', a continuous measure of arousability. Airflow limitation was assessed by duty cycle (T i /T t) and % of breaths with flow limitation, and hypoxia by â € hypoxic burden'. Primary outcomes were medication-adjusted systolic BP (SBP) and diastolic BP (DBP). We used generalised linear models adjusted for age, sex, race/ethnicity, smoking, education, body mass index, alcohol use, periodic limb movements and alternative physiological disturbances. Results The sample had a mean age of 68.4 years and apnoea-hypopnoea index of 14.8 events/hour. Sleep depth was not significantly associated with BP. Every 1 SD increment in log-transformed non-rapid eye movement duty cycle was associated with 0.9% decrease in SBP (95% CI: 0.1% to 1.6%), even after adjusting for sleep depth and hypoxic burden. Every 1 SD increment in log-transformed hypoxic burden was associated with a 1.1% increase in SBP (95% CI: 0.1% to 2.1%) and 1.9% increase in DBP (95% CI: 1.0% to 2.8%) among those not using hypertension medications. Conclusions Higher duty cycle was associated with lower SBP overall and hypoxic burden with higher SBP and DBP among non-BP medication users. These findings suggest changes in both respiratory effort and oxygenation during sleep influence BP.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalThorax
Volume75
Issue number1
DOIs
StatePublished - Jan 1 2020

Keywords

  • duty cycle
  • hypertension
  • hypoxia
  • inspiratory flow limitation
  • sleep apnoea

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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