Abstract
Objectives: To assess the cross-sectional association of regular use of nonsteroidal antiinflammatory drugs (NSAIDs) or aspirin with cognitive function in 13,153 individuals, aged 48-67 years, participating in the Atherosclerosis Risk in Communities (ARIC) Study. Methods: Regular use of NSAIDs or aspirin was analyzed in relation to the results of three cognitive tests, the Delayed Word Recall Test, the WAIS-R Digit Symbol Subtest, and the Word Fluency Test. Results: After adjustment for covariates previously found to be associated with cognition in this sample, we found a weak negative association between current use of aspirin and poor Word Recall [OR = 0.84 (95% confidence interval: 0.68-1.04)] and poor Word Fluency [OR = 0.85 (0.70- 1.03)]. We found no association between current use of aspirin and Digit Symbol score, nor did we find current NSAID use to be significantly associated with any of the cognitive tests. Conclusions: This study suggests a modest association, at best, between NSAIDs or aspirin and better cognitive function.
Original language | English (US) |
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Pages (from-to) | 134-143 |
Number of pages | 10 |
Journal | Neuroepidemiology |
Volume | 18 |
Issue number | 3 |
DOIs | |
State | Published - Jan 1 1999 |
Keywords
- Aspirin
- Cognition
- Cross-sectional study
- Epidemiology
- Nonsteroidal anti-inflammatory drugs
ASJC Scopus subject areas
- Epidemiology
- Clinical Neurology