TY - JOUR
T1 - Association of mucoid degeneration of anterior cruciate ligament with knee meniscal and cartilage damage
AU - Kwee, R. M.
AU - Ahlawat, S.
AU - Kompel, A. J.
AU - Morelli, J. N.
AU - Fayad, L. M.
AU - Zikria, B. A.
AU - Demehri, S.
N1 - Funding Information:
We would like to acknowledge partial support for the statistical analysis from the National Center for Research Resources and the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health through Grant Number UL1T000424 . We also would like to thank Dr Nima Hafezi-Nejad for helping revising the manuscript.
Publisher Copyright:
© 2015 Osteoarthritis Research Society International.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Objective: To assess the prevalence of anterior cruciate ligament (ACL) mucoid degeneration in patients referred for routine knee magnetic resonance (MR) imaging, and its association with age and structural joint damage. Method: Four independent radiologists assessed 413 consecutive knee MR examinations for the presence of a normal or ruptured ACL, or ACL mucoid degeneration. Knees with ACL mucoid degeneration were frequency matched by age, sex, and MR field strength with consecutive control knees with a normal ACL (1:2 ratio). Differences in meniscal and cartilage damage of the tibiofemoral compartments, as determined by the Whole-Organ MR Imaging Score (WORMS) system, were compared by Mann-Whitney U tests. Multivariable logistic regression analysis identified the association of ACL mucoid degeneration with severe MTFC cartilage damage (WORMS≥5). Results: Patients with ACL mucoid degeneration ( n = 36; 36% males; median age 55.5 years, range: 26-81) were older than patients with a normal ( P < 0.001) or ruptured ACL ( P < 0.001), without sex predilection ( P = 0.76), and were more frequently diagnosed at 3 T (12%) compared to 1.5 T (2%). Knees with ACL mucoid degeneration had statistically significantly more medial meniscal ( P < 0.001) and central and posterior medial tibiofemoral compartment (MTFC) cartilage ( P < 0.001) damage compared with control knees ( n = 72), but there were no differences in patients ≤50 years ( P = 0.09 and 0.32, respectively). In multivariable logistic regression, severe MTFC cartilage damage (WORMS≥5) was significantly associated with ACL mucoid degeneration (odds ratio 4.09, 95% confidence interval 1.29-12.94, P = 0.016). Conclusion: There is a strong association between ACL mucoid degeneration and cartilage damage in the central and posterior MTFC, especially in patients >50 years.
AB - Objective: To assess the prevalence of anterior cruciate ligament (ACL) mucoid degeneration in patients referred for routine knee magnetic resonance (MR) imaging, and its association with age and structural joint damage. Method: Four independent radiologists assessed 413 consecutive knee MR examinations for the presence of a normal or ruptured ACL, or ACL mucoid degeneration. Knees with ACL mucoid degeneration were frequency matched by age, sex, and MR field strength with consecutive control knees with a normal ACL (1:2 ratio). Differences in meniscal and cartilage damage of the tibiofemoral compartments, as determined by the Whole-Organ MR Imaging Score (WORMS) system, were compared by Mann-Whitney U tests. Multivariable logistic regression analysis identified the association of ACL mucoid degeneration with severe MTFC cartilage damage (WORMS≥5). Results: Patients with ACL mucoid degeneration ( n = 36; 36% males; median age 55.5 years, range: 26-81) were older than patients with a normal ( P < 0.001) or ruptured ACL ( P < 0.001), without sex predilection ( P = 0.76), and were more frequently diagnosed at 3 T (12%) compared to 1.5 T (2%). Knees with ACL mucoid degeneration had statistically significantly more medial meniscal ( P < 0.001) and central and posterior medial tibiofemoral compartment (MTFC) cartilage ( P < 0.001) damage compared with control knees ( n = 72), but there were no differences in patients ≤50 years ( P = 0.09 and 0.32, respectively). In multivariable logistic regression, severe MTFC cartilage damage (WORMS≥5) was significantly associated with ACL mucoid degeneration (odds ratio 4.09, 95% confidence interval 1.29-12.94, P = 0.016). Conclusion: There is a strong association between ACL mucoid degeneration and cartilage damage in the central and posterior MTFC, especially in patients >50 years.
KW - Anterior cruciate ligament
KW - Cartilage
KW - Magnetic resonance imaging
KW - Menisci
KW - Mucoid degeneration
KW - Osteoarthritis
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U2 - 10.1016/j.joca.2015.04.013
DO - 10.1016/j.joca.2015.04.013
M3 - Article
C2 - 25907861
AN - SCOPUS:84940451416
SN - 1063-4584
VL - 23
SP - 1543
EP - 1550
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
IS - 9
ER -