Association of mood disorders with cardiovascular disease risk factors in overweight and obese youth with elevated blood pressure

Leah Medrano, Kaushalendra Amatya, Diane Vizthum, Jeffrey J. Fadrowski, Tammy McLoughlin Brady

Research output: Contribution to journalArticle


The American Heart Association defines mood disorders (MDO) as a tier-II cardiovascular disease risk factor in children. Cross-sectional analysis of overweight/obese children referred to an obesity hypertension clinic revealed 37% had a MDO (defined by clinical diagnosis or Patient Health Questionnaire-9/-A score ≥10), 55% had confirmed hypertension, and 75% left ventricular hypertrophy (LVH). Children with MDOs were older, had greater measures of adiposity, and had a greater prevalence of hypertension (78%) than those without MDOs (42%; P = .04). Hypertensive children were 2.8 times more likely to have a MDO than those without (52% vs 18%; P = .02). Multivariable logistic regression revealed a statistically significant independent association of MDOs with hypertension (Odds Ratio [OR] 6.3, P = .048), but not LVH (LVMI ≥ 51 g/m2.7; OR 1.13, P = .88). Overall, the prevalence of MDOs in this group of overweight/obese children with elevated blood pressure was well above national averages, suggesting that at-risk youth, particularly those with confirmed hypertension, should be regularly screened for MDOs.

Original languageEnglish (US)
JournalJournal of clinical hypertension
Publication statusAccepted/In press - Jan 1 2018



  • Adolescents
  • Cardiovascular disease
  • Children
  • Hypertension
  • Left ventricular hypertrophy
  • Mood disorders
  • Obesity
  • Overweight
  • Pediatrics

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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