Association of menopause age and N-terminal pro brain natriuretic peptide: The Multi-Ethnic Study of Atherosclerosis

Imo A. Ebong, Karol E. Watson, David C. Goff, David A. Bluemke, Preethi Srikanthan, Tamara Horwich, Alain G. Bertoni

Research output: Contribution to journalArticle

Abstract

Objective Menopause age can affect the risk of developing cardiovascular disease (CVD). The purpose of this study was to investigate the associations of early menopause (menopause occurring before age 45 y) and menopause age with N-terminal pro brain natriuretic peptide (NT-proBNP), a potential risk marker of CVD and heart failure. Methods Our cross-sectional study included 2,275 postmenopausal women, aged 45 to 85 years and without clinical CVD (2000-2002), from the Multi-Ethnic Study of Atherosclerosis. Participants were classified as having or not having early menopause. NT-proBNP was log-transformed. Multivariable linear regression was used for analysis. Results Five hundred sixty-one women had early menopause. The median (25th-75th percentiles) NT-proBNP value was 79.0 (41.1-151.6) pg/mL for all participants, 83.4 (41.4-164.9) pg/mL for women with early menopause, and 78.0 (40.8-148.3) pg/mL for women without early menopause. The mean (SD) age was 65 (10.1) and 65 (8.9) years for women with and without early menopause, respectively. No significant interactions between menopause age and ethnicity were observed. In multivariable analysis, early menopause was associated with a 10.7% increase in NT-proBNP levels, whereas each 1-year increase in menopause age was associated with a 0.7% decrease in NT-proBNP levels. Conclusions Early menopause is associated with greater NT-proBNP levels, whereas each 1-year increase in menopause age is associated with lower NT-proBNP levels, in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)527-533
Number of pages7
JournalMenopause
Volume22
Issue number5
DOIs
StatePublished - May 9 2015
Externally publishedYes

Fingerprint

Brain Natriuretic Peptide
Menopause
Atherosclerosis
Cardiovascular Diseases
Linear Models

Keywords

  • Menopause
  • N-Terminal pro brain natriuretic peptide
  • Sex hormones

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Ebong, I. A., Watson, K. E., Goff, D. C., Bluemke, D. A., Srikanthan, P., Horwich, T., & Bertoni, A. G. (2015). Association of menopause age and N-terminal pro brain natriuretic peptide: The Multi-Ethnic Study of Atherosclerosis. Menopause, 22(5), 527-533. https://doi.org/10.1097/GME.0000000000000342

Association of menopause age and N-terminal pro brain natriuretic peptide : The Multi-Ethnic Study of Atherosclerosis. / Ebong, Imo A.; Watson, Karol E.; Goff, David C.; Bluemke, David A.; Srikanthan, Preethi; Horwich, Tamara; Bertoni, Alain G.

In: Menopause, Vol. 22, No. 5, 09.05.2015, p. 527-533.

Research output: Contribution to journalArticle

Ebong, IA, Watson, KE, Goff, DC, Bluemke, DA, Srikanthan, P, Horwich, T & Bertoni, AG 2015, 'Association of menopause age and N-terminal pro brain natriuretic peptide: The Multi-Ethnic Study of Atherosclerosis', Menopause, vol. 22, no. 5, pp. 527-533. https://doi.org/10.1097/GME.0000000000000342
Ebong, Imo A. ; Watson, Karol E. ; Goff, David C. ; Bluemke, David A. ; Srikanthan, Preethi ; Horwich, Tamara ; Bertoni, Alain G. / Association of menopause age and N-terminal pro brain natriuretic peptide : The Multi-Ethnic Study of Atherosclerosis. In: Menopause. 2015 ; Vol. 22, No. 5. pp. 527-533.
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abstract = "Objective Menopause age can affect the risk of developing cardiovascular disease (CVD). The purpose of this study was to investigate the associations of early menopause (menopause occurring before age 45 y) and menopause age with N-terminal pro brain natriuretic peptide (NT-proBNP), a potential risk marker of CVD and heart failure. Methods Our cross-sectional study included 2,275 postmenopausal women, aged 45 to 85 years and without clinical CVD (2000-2002), from the Multi-Ethnic Study of Atherosclerosis. Participants were classified as having or not having early menopause. NT-proBNP was log-transformed. Multivariable linear regression was used for analysis. Results Five hundred sixty-one women had early menopause. The median (25th-75th percentiles) NT-proBNP value was 79.0 (41.1-151.6) pg/mL for all participants, 83.4 (41.4-164.9) pg/mL for women with early menopause, and 78.0 (40.8-148.3) pg/mL for women without early menopause. The mean (SD) age was 65 (10.1) and 65 (8.9) years for women with and without early menopause, respectively. No significant interactions between menopause age and ethnicity were observed. In multivariable analysis, early menopause was associated with a 10.7{\%} increase in NT-proBNP levels, whereas each 1-year increase in menopause age was associated with a 0.7{\%} decrease in NT-proBNP levels. Conclusions Early menopause is associated with greater NT-proBNP levels, whereas each 1-year increase in menopause age is associated with lower NT-proBNP levels, in postmenopausal women.",
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AU - Goff, David C.

AU - Bluemke, David A.

AU - Srikanthan, Preethi

AU - Horwich, Tamara

AU - Bertoni, Alain G.

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N2 - Objective Menopause age can affect the risk of developing cardiovascular disease (CVD). The purpose of this study was to investigate the associations of early menopause (menopause occurring before age 45 y) and menopause age with N-terminal pro brain natriuretic peptide (NT-proBNP), a potential risk marker of CVD and heart failure. Methods Our cross-sectional study included 2,275 postmenopausal women, aged 45 to 85 years and without clinical CVD (2000-2002), from the Multi-Ethnic Study of Atherosclerosis. Participants were classified as having or not having early menopause. NT-proBNP was log-transformed. Multivariable linear regression was used for analysis. Results Five hundred sixty-one women had early menopause. The median (25th-75th percentiles) NT-proBNP value was 79.0 (41.1-151.6) pg/mL for all participants, 83.4 (41.4-164.9) pg/mL for women with early menopause, and 78.0 (40.8-148.3) pg/mL for women without early menopause. The mean (SD) age was 65 (10.1) and 65 (8.9) years for women with and without early menopause, respectively. No significant interactions between menopause age and ethnicity were observed. In multivariable analysis, early menopause was associated with a 10.7% increase in NT-proBNP levels, whereas each 1-year increase in menopause age was associated with a 0.7% decrease in NT-proBNP levels. Conclusions Early menopause is associated with greater NT-proBNP levels, whereas each 1-year increase in menopause age is associated with lower NT-proBNP levels, in postmenopausal women.

AB - Objective Menopause age can affect the risk of developing cardiovascular disease (CVD). The purpose of this study was to investigate the associations of early menopause (menopause occurring before age 45 y) and menopause age with N-terminal pro brain natriuretic peptide (NT-proBNP), a potential risk marker of CVD and heart failure. Methods Our cross-sectional study included 2,275 postmenopausal women, aged 45 to 85 years and without clinical CVD (2000-2002), from the Multi-Ethnic Study of Atherosclerosis. Participants were classified as having or not having early menopause. NT-proBNP was log-transformed. Multivariable linear regression was used for analysis. Results Five hundred sixty-one women had early menopause. The median (25th-75th percentiles) NT-proBNP value was 79.0 (41.1-151.6) pg/mL for all participants, 83.4 (41.4-164.9) pg/mL for women with early menopause, and 78.0 (40.8-148.3) pg/mL for women without early menopause. The mean (SD) age was 65 (10.1) and 65 (8.9) years for women with and without early menopause, respectively. No significant interactions between menopause age and ethnicity were observed. In multivariable analysis, early menopause was associated with a 10.7% increase in NT-proBNP levels, whereas each 1-year increase in menopause age was associated with a 0.7% decrease in NT-proBNP levels. Conclusions Early menopause is associated with greater NT-proBNP levels, whereas each 1-year increase in menopause age is associated with lower NT-proBNP levels, in postmenopausal women.

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