Association of medical male circumcision and antiretroviral therapyscale-up with community HIV incidence in Rakai, Uganda

Xiangrong Kong, Godfrey Kigozi, Joseph Ssekasanvu, Fred Nalugoda, Gertrude Nakigozi, Anthony Ndyanabo, Tom Lutalo, Steven J. Reynolds, Robert Ssekubugu, Joseph Kagaayi, Eva Bugos, Larry W. Chang, Pilgrim Nanlesta, Grabowski Mary, Amanda Berman, Thomas C. Quinn, David Serwadda, Maria J. Wawer, Ronald H. Gray

Research output: Contribution to journalArticle

Abstract

IMPORTANCE: Medical male circumcision (MMC) and antiretroviral therapy (ART) are proven HIV prevention interventions, but there are limited data on the population-level effect of scale-up of these interventions in sub-Saharan Africa. Such evaluation is important for planning and resource allocation. OBJECTIVE: To examine whether increasing community MMC and ART coverage was associated with reduced community HIV incidence in Rakai District, Uganda. DESIGN, SETTING, AND PARTICIPANTS: Using person-level data from population-based surveys conducted from 1999 through 2013 in 45 rural Rakai communities, community-level ART and MMC coverage, sociodemographics, sexual behaviors, and HIV prevalence and incidence were estimated in 3 periods: prior to the availability of ART and MMC (1999-2004), during early availability of ART and MMC (2004-2007), and during mature program scale-up (2007-2013). EXPOSURES: Community MMC coverage in males and ART coverage in HIV-positive persons of the opposite sex based on self-reported MMC status and ART use. MAIN OUTCOMES AND MEASURES: Adjusted incidence rate ratios (IRRs) for sex-specific community HIV incidence estimated using multivariable Poisson regression with generalized estimating equations. RESULTS: From 1999 through 2013, 44 688 persons participated in 1 or more surveys (mean age at the first survey, 24.6 years [range, 15-49]; female, 56.5%; mean survey participation rate, 92.6% [95% CI, 92.4%-92.7%]). Median community MMC coverage increased from 19% to 39%, and median community ART coverage rose from 0% to 21% in males and from 0% to 26% in females. Median community HIV incidence declined from 1.25 to 0.84 per 100 person-years in males, and from 1.25 to 0.99 per 100 person-years in females. Among males, each 10% increase in community MMC coverage was associated with an adjusted IRR of 0.87 (95% CI, 0.82-0.93). Comparing communities with MMC coverage more than 40% (mean male community incidence, 1.03 per 100 person-years) with communities with coverage of 10% or less (mean male incidence, 1.69 per 100 person-years), the adjusted IRR was 0.61 (95% CI, 0.43-0.88). For each 10% increase in female self-reported ART coverage, there was no significant reduction in male HIV incidence (adjusted IRR, 0.95 [95% CI, 0.81-1.13]). Comparing communities with female ART coverage more than 20% (mean male incidence, 0.87 per 100 person-years) to communities with female ART coverage of 20% or less (mean male incidence, 1.17 per 100 person-years), the adjusted IRR was 0.77 (95% CI, 0.61-0.98). Neither MMC nor male ART coverage was associated with lower female community HIV incidence. CONCLUSIONS AND RELEVANCE: In Rakai, Uganda, increasing community MMC and female ART coverage was associated with lower community HIV incidence in males. If similar associations are found elsewhere, this would support further scale-up of MMC and ART for HIV prevention in sub-Saharan Africa.

Original languageEnglish (US)
Pages (from-to)182-190
Number of pages9
JournalJAMA - Journal of the American Medical Association
Volume316
Issue number2
DOIs
StatePublished - Jul 12 2016

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Male Circumcision
Uganda
HIV
Incidence
Therapeutics
Africa South of the Sahara
Resource Allocation
Sex Ratio
Rural Population

ASJC Scopus subject areas

  • Medicine(all)

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Association of medical male circumcision and antiretroviral therapyscale-up with community HIV incidence in Rakai, Uganda. / Kong, Xiangrong; Kigozi, Godfrey; Ssekasanvu, Joseph; Nalugoda, Fred; Nakigozi, Gertrude; Ndyanabo, Anthony; Lutalo, Tom; Reynolds, Steven J.; Ssekubugu, Robert; Kagaayi, Joseph; Bugos, Eva; Chang, Larry W.; Nanlesta, Pilgrim; Mary, Grabowski; Berman, Amanda; Quinn, Thomas C.; Serwadda, David; Wawer, Maria J.; Gray, Ronald H.

In: JAMA - Journal of the American Medical Association, Vol. 316, No. 2, 12.07.2016, p. 182-190.

Research output: Contribution to journalArticle

Kong, X, Kigozi, G, Ssekasanvu, J, Nalugoda, F, Nakigozi, G, Ndyanabo, A, Lutalo, T, Reynolds, SJ, Ssekubugu, R, Kagaayi, J, Bugos, E, Chang, LW, Nanlesta, P, Mary, G, Berman, A, Quinn, TC, Serwadda, D, Wawer, MJ & Gray, RH 2016, 'Association of medical male circumcision and antiretroviral therapyscale-up with community HIV incidence in Rakai, Uganda', JAMA - Journal of the American Medical Association, vol. 316, no. 2, pp. 182-190. https://doi.org/10.1001/jama.2016.7292
Kong, Xiangrong ; Kigozi, Godfrey ; Ssekasanvu, Joseph ; Nalugoda, Fred ; Nakigozi, Gertrude ; Ndyanabo, Anthony ; Lutalo, Tom ; Reynolds, Steven J. ; Ssekubugu, Robert ; Kagaayi, Joseph ; Bugos, Eva ; Chang, Larry W. ; Nanlesta, Pilgrim ; Mary, Grabowski ; Berman, Amanda ; Quinn, Thomas C. ; Serwadda, David ; Wawer, Maria J. ; Gray, Ronald H. / Association of medical male circumcision and antiretroviral therapyscale-up with community HIV incidence in Rakai, Uganda. In: JAMA - Journal of the American Medical Association. 2016 ; Vol. 316, No. 2. pp. 182-190.
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abstract = "IMPORTANCE: Medical male circumcision (MMC) and antiretroviral therapy (ART) are proven HIV prevention interventions, but there are limited data on the population-level effect of scale-up of these interventions in sub-Saharan Africa. Such evaluation is important for planning and resource allocation. OBJECTIVE: To examine whether increasing community MMC and ART coverage was associated with reduced community HIV incidence in Rakai District, Uganda. DESIGN, SETTING, AND PARTICIPANTS: Using person-level data from population-based surveys conducted from 1999 through 2013 in 45 rural Rakai communities, community-level ART and MMC coverage, sociodemographics, sexual behaviors, and HIV prevalence and incidence were estimated in 3 periods: prior to the availability of ART and MMC (1999-2004), during early availability of ART and MMC (2004-2007), and during mature program scale-up (2007-2013). EXPOSURES: Community MMC coverage in males and ART coverage in HIV-positive persons of the opposite sex based on self-reported MMC status and ART use. MAIN OUTCOMES AND MEASURES: Adjusted incidence rate ratios (IRRs) for sex-specific community HIV incidence estimated using multivariable Poisson regression with generalized estimating equations. RESULTS: From 1999 through 2013, 44 688 persons participated in 1 or more surveys (mean age at the first survey, 24.6 years [range, 15-49]; female, 56.5{\%}; mean survey participation rate, 92.6{\%} [95{\%} CI, 92.4{\%}-92.7{\%}]). Median community MMC coverage increased from 19{\%} to 39{\%}, and median community ART coverage rose from 0{\%} to 21{\%} in males and from 0{\%} to 26{\%} in females. Median community HIV incidence declined from 1.25 to 0.84 per 100 person-years in males, and from 1.25 to 0.99 per 100 person-years in females. Among males, each 10{\%} increase in community MMC coverage was associated with an adjusted IRR of 0.87 (95{\%} CI, 0.82-0.93). Comparing communities with MMC coverage more than 40{\%} (mean male community incidence, 1.03 per 100 person-years) with communities with coverage of 10{\%} or less (mean male incidence, 1.69 per 100 person-years), the adjusted IRR was 0.61 (95{\%} CI, 0.43-0.88). For each 10{\%} increase in female self-reported ART coverage, there was no significant reduction in male HIV incidence (adjusted IRR, 0.95 [95{\%} CI, 0.81-1.13]). Comparing communities with female ART coverage more than 20{\%} (mean male incidence, 0.87 per 100 person-years) to communities with female ART coverage of 20{\%} or less (mean male incidence, 1.17 per 100 person-years), the adjusted IRR was 0.77 (95{\%} CI, 0.61-0.98). Neither MMC nor male ART coverage was associated with lower female community HIV incidence. CONCLUSIONS AND RELEVANCE: In Rakai, Uganda, increasing community MMC and female ART coverage was associated with lower community HIV incidence in males. If similar associations are found elsewhere, this would support further scale-up of MMC and ART for HIV prevention in sub-Saharan Africa.",
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TY - JOUR

T1 - Association of medical male circumcision and antiretroviral therapyscale-up with community HIV incidence in Rakai, Uganda

AU - Kong, Xiangrong

AU - Kigozi, Godfrey

AU - Ssekasanvu, Joseph

AU - Nalugoda, Fred

AU - Nakigozi, Gertrude

AU - Ndyanabo, Anthony

AU - Lutalo, Tom

AU - Reynolds, Steven J.

AU - Ssekubugu, Robert

AU - Kagaayi, Joseph

AU - Bugos, Eva

AU - Chang, Larry W.

AU - Nanlesta, Pilgrim

AU - Mary, Grabowski

AU - Berman, Amanda

AU - Quinn, Thomas C.

AU - Serwadda, David

AU - Wawer, Maria J.

AU - Gray, Ronald H.

PY - 2016/7/12

Y1 - 2016/7/12

N2 - IMPORTANCE: Medical male circumcision (MMC) and antiretroviral therapy (ART) are proven HIV prevention interventions, but there are limited data on the population-level effect of scale-up of these interventions in sub-Saharan Africa. Such evaluation is important for planning and resource allocation. OBJECTIVE: To examine whether increasing community MMC and ART coverage was associated with reduced community HIV incidence in Rakai District, Uganda. DESIGN, SETTING, AND PARTICIPANTS: Using person-level data from population-based surveys conducted from 1999 through 2013 in 45 rural Rakai communities, community-level ART and MMC coverage, sociodemographics, sexual behaviors, and HIV prevalence and incidence were estimated in 3 periods: prior to the availability of ART and MMC (1999-2004), during early availability of ART and MMC (2004-2007), and during mature program scale-up (2007-2013). EXPOSURES: Community MMC coverage in males and ART coverage in HIV-positive persons of the opposite sex based on self-reported MMC status and ART use. MAIN OUTCOMES AND MEASURES: Adjusted incidence rate ratios (IRRs) for sex-specific community HIV incidence estimated using multivariable Poisson regression with generalized estimating equations. RESULTS: From 1999 through 2013, 44 688 persons participated in 1 or more surveys (mean age at the first survey, 24.6 years [range, 15-49]; female, 56.5%; mean survey participation rate, 92.6% [95% CI, 92.4%-92.7%]). Median community MMC coverage increased from 19% to 39%, and median community ART coverage rose from 0% to 21% in males and from 0% to 26% in females. Median community HIV incidence declined from 1.25 to 0.84 per 100 person-years in males, and from 1.25 to 0.99 per 100 person-years in females. Among males, each 10% increase in community MMC coverage was associated with an adjusted IRR of 0.87 (95% CI, 0.82-0.93). Comparing communities with MMC coverage more than 40% (mean male community incidence, 1.03 per 100 person-years) with communities with coverage of 10% or less (mean male incidence, 1.69 per 100 person-years), the adjusted IRR was 0.61 (95% CI, 0.43-0.88). For each 10% increase in female self-reported ART coverage, there was no significant reduction in male HIV incidence (adjusted IRR, 0.95 [95% CI, 0.81-1.13]). Comparing communities with female ART coverage more than 20% (mean male incidence, 0.87 per 100 person-years) to communities with female ART coverage of 20% or less (mean male incidence, 1.17 per 100 person-years), the adjusted IRR was 0.77 (95% CI, 0.61-0.98). Neither MMC nor male ART coverage was associated with lower female community HIV incidence. CONCLUSIONS AND RELEVANCE: In Rakai, Uganda, increasing community MMC and female ART coverage was associated with lower community HIV incidence in males. If similar associations are found elsewhere, this would support further scale-up of MMC and ART for HIV prevention in sub-Saharan Africa.

AB - IMPORTANCE: Medical male circumcision (MMC) and antiretroviral therapy (ART) are proven HIV prevention interventions, but there are limited data on the population-level effect of scale-up of these interventions in sub-Saharan Africa. Such evaluation is important for planning and resource allocation. OBJECTIVE: To examine whether increasing community MMC and ART coverage was associated with reduced community HIV incidence in Rakai District, Uganda. DESIGN, SETTING, AND PARTICIPANTS: Using person-level data from population-based surveys conducted from 1999 through 2013 in 45 rural Rakai communities, community-level ART and MMC coverage, sociodemographics, sexual behaviors, and HIV prevalence and incidence were estimated in 3 periods: prior to the availability of ART and MMC (1999-2004), during early availability of ART and MMC (2004-2007), and during mature program scale-up (2007-2013). EXPOSURES: Community MMC coverage in males and ART coverage in HIV-positive persons of the opposite sex based on self-reported MMC status and ART use. MAIN OUTCOMES AND MEASURES: Adjusted incidence rate ratios (IRRs) for sex-specific community HIV incidence estimated using multivariable Poisson regression with generalized estimating equations. RESULTS: From 1999 through 2013, 44 688 persons participated in 1 or more surveys (mean age at the first survey, 24.6 years [range, 15-49]; female, 56.5%; mean survey participation rate, 92.6% [95% CI, 92.4%-92.7%]). Median community MMC coverage increased from 19% to 39%, and median community ART coverage rose from 0% to 21% in males and from 0% to 26% in females. Median community HIV incidence declined from 1.25 to 0.84 per 100 person-years in males, and from 1.25 to 0.99 per 100 person-years in females. Among males, each 10% increase in community MMC coverage was associated with an adjusted IRR of 0.87 (95% CI, 0.82-0.93). Comparing communities with MMC coverage more than 40% (mean male community incidence, 1.03 per 100 person-years) with communities with coverage of 10% or less (mean male incidence, 1.69 per 100 person-years), the adjusted IRR was 0.61 (95% CI, 0.43-0.88). For each 10% increase in female self-reported ART coverage, there was no significant reduction in male HIV incidence (adjusted IRR, 0.95 [95% CI, 0.81-1.13]). Comparing communities with female ART coverage more than 20% (mean male incidence, 0.87 per 100 person-years) to communities with female ART coverage of 20% or less (mean male incidence, 1.17 per 100 person-years), the adjusted IRR was 0.77 (95% CI, 0.61-0.98). Neither MMC nor male ART coverage was associated with lower female community HIV incidence. CONCLUSIONS AND RELEVANCE: In Rakai, Uganda, increasing community MMC and female ART coverage was associated with lower community HIV incidence in males. If similar associations are found elsewhere, this would support further scale-up of MMC and ART for HIV prevention in sub-Saharan Africa.

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