Association of matrix metalloproteinase-1 polymorphisms with risk of COPD and lung cancer and survival in lung cancer

Lindsey Enewold, Leah E. Mechanic, Elise D. Bowman, Elizabeth A. Platz, Anthony J. Alberg

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: The primary risk factor for chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC) is cigarette smoking but shared susceptibility factors, such as variations in the matrix metalloproteinase-1 (MMP1) gene, may also underlie both diseases. Materials and Methods: Cases with prevalent COPD (n=167), incident NSCLC (n=242), or prevalent COPD plus incident NSCLC (n=128) were compared to disease-free controls (n=338) to assess six MMP1 polymorphisms. The association between these polymorphisms and survival in NSCLC was also evaluated. Results: Rs11292517 among African-Americans [odds ratio (OR)=5.48, 95% confidence interval (CI)=1.17-25.72] and rs2071230 among Caucasians (OR=2.51, 95% CI=1.09-5.77) appeared to be associated with NSCLC risk in the presence of COPD. Rs470558 appeared to be associated with survival in NSCLC among African-Americans (hazard ratio=3.94; 95%CI=1.14-13.63). No associations remained after adjusting for multiple comparisons. Conclusion: Polymorphisms in MMP1 were not consistently associated with prevalent COPD or incident NSCLC nor with survival in NSCLC.

Original languageEnglish (US)
Pages (from-to)3917-3922
Number of pages6
JournalAnticancer research
Volume32
Issue number9
StatePublished - Sep 2012

Keywords

  • Case-control
  • Chronic bronchitis
  • Emphysema
  • Gene polymorphism
  • Lung cancer
  • Matrix metalloproteinase-1
  • Survival
  • rs11292517

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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