Abstract
Background: The primary risk factor for chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC) is cigarette smoking but shared susceptibility factors, such as variations in the matrix metalloproteinase-1 (MMP1) gene, may also underlie both diseases. Materials and Methods: Cases with prevalent COPD (n=167), incident NSCLC (n=242), or prevalent COPD plus incident NSCLC (n=128) were compared to disease-free controls (n=338) to assess six MMP1 polymorphisms. The association between these polymorphisms and survival in NSCLC was also evaluated. Results: Rs11292517 among African-Americans [odds ratio (OR)=5.48, 95% confidence interval (CI)=1.17-25.72] and rs2071230 among Caucasians (OR=2.51, 95% CI=1.09-5.77) appeared to be associated with NSCLC risk in the presence of COPD. Rs470558 appeared to be associated with survival in NSCLC among African-Americans (hazard ratio=3.94; 95%CI=1.14-13.63). No associations remained after adjusting for multiple comparisons. Conclusion: Polymorphisms in MMP1 were not consistently associated with prevalent COPD or incident NSCLC nor with survival in NSCLC.
Original language | English (US) |
---|---|
Pages (from-to) | 3917-3922 |
Number of pages | 6 |
Journal | Anticancer research |
Volume | 32 |
Issue number | 9 |
State | Published - Sep 2012 |
Keywords
- Case-control
- Chronic bronchitis
- Emphysema
- Gene polymorphism
- Lung cancer
- Matrix metalloproteinase-1
- Survival
- rs11292517
ASJC Scopus subject areas
- Oncology
- Cancer Research