Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission

Evelyn M. Rodriguez, Lynne M. Mofenson, Bei Hung Chang, Kenneth C. Rich, Mary Glenn Fowler, Vincent Smeriglio, Sheldon Landesman, Harold E. Fox, Clemente Diaz, Karen Green, I. Celine Hanson

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the relationship of drug use with maternal HIV culture positivity at delivery and perinatal HIV transmission. Design: Multicenter prospective cohort study. Setting: Obstetric and pediatric clinics in five cities in the United States. Participants: Five hundred and thirty HIV-infected pregnant women and their infants. Main outcome measures: Multivariate logistic regression was used to evaluate the association of 'hard drug' use (one or more of the following: cocaine, heroin/opiates, methadone, injecting drug use) assessed by self-report and urine toxicology with positive maternal HIV culture at delivery and perinatal HIV transmission. Results: Forty-two per cent of women used hard drugs during pregnancy. Increased probability of a positive maternal delivery HIV culture was significantly associated with prenatal hard drug use [odds ratio (OR), 3.08] and maternal cocaine use (OR, 2.98) among HIV-infected women with > 29% CD4+ lymphocytes. After adjusting for maternal culture positivity at delivery, CD4+ lymphocyte percentage and gestational age, significantly greater transmission risk was observed with hard drug use among women with membrane rupture > 4 h. Conclusions: On the basis of self-report and urine toxicology, overall maternal hard drug use and cocaine use in the WITS cohort were associated with maternal HIV culture positivity at delivery, and maternal hard drug use was associated with perinatal transmission.

Original languageEnglish (US)
Pages (from-to)273-282
Number of pages10
JournalAIDS
Volume10
Issue number3
StatePublished - 1996

Fingerprint

Mothers
HIV
Pregnancy
Pharmaceutical Preparations
Cocaine
Toxicology
Self Report
Opiate Alkaloids
Odds Ratio
Urine
Lymphocytes
Methadone
Heroin
Gestational Age
Obstetrics
Pregnant Women
Rupture
Cohort Studies
Logistic Models
Outcome Assessment (Health Care)

Keywords

  • Gynecology
  • Obstetrics
  • Pediatrics
  • Pregnancy
  • Prenatal drug use
  • Risk factors
  • Vertical HIV transmission
  • Women

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Rodriguez, E. M., Mofenson, L. M., Chang, B. H., Rich, K. C., Fowler, M. G., Smeriglio, V., ... Hanson, I. C. (1996). Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission. AIDS, 10(3), 273-282.

Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission. / Rodriguez, Evelyn M.; Mofenson, Lynne M.; Chang, Bei Hung; Rich, Kenneth C.; Fowler, Mary Glenn; Smeriglio, Vincent; Landesman, Sheldon; Fox, Harold E.; Diaz, Clemente; Green, Karen; Hanson, I. Celine.

In: AIDS, Vol. 10, No. 3, 1996, p. 273-282.

Research output: Contribution to journalArticle

Rodriguez, EM, Mofenson, LM, Chang, BH, Rich, KC, Fowler, MG, Smeriglio, V, Landesman, S, Fox, HE, Diaz, C, Green, K & Hanson, IC 1996, 'Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission', AIDS, vol. 10, no. 3, pp. 273-282.
Rodriguez EM, Mofenson LM, Chang BH, Rich KC, Fowler MG, Smeriglio V et al. Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission. AIDS. 1996;10(3):273-282.
Rodriguez, Evelyn M. ; Mofenson, Lynne M. ; Chang, Bei Hung ; Rich, Kenneth C. ; Fowler, Mary Glenn ; Smeriglio, Vincent ; Landesman, Sheldon ; Fox, Harold E. ; Diaz, Clemente ; Green, Karen ; Hanson, I. Celine. / Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission. In: AIDS. 1996 ; Vol. 10, No. 3. pp. 273-282.
@article{3000b60409014a70abf7f8cd82104d53,
title = "Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission",
abstract = "Objective: To evaluate the relationship of drug use with maternal HIV culture positivity at delivery and perinatal HIV transmission. Design: Multicenter prospective cohort study. Setting: Obstetric and pediatric clinics in five cities in the United States. Participants: Five hundred and thirty HIV-infected pregnant women and their infants. Main outcome measures: Multivariate logistic regression was used to evaluate the association of 'hard drug' use (one or more of the following: cocaine, heroin/opiates, methadone, injecting drug use) assessed by self-report and urine toxicology with positive maternal HIV culture at delivery and perinatal HIV transmission. Results: Forty-two per cent of women used hard drugs during pregnancy. Increased probability of a positive maternal delivery HIV culture was significantly associated with prenatal hard drug use [odds ratio (OR), 3.08] and maternal cocaine use (OR, 2.98) among HIV-infected women with > 29{\%} CD4+ lymphocytes. After adjusting for maternal culture positivity at delivery, CD4+ lymphocyte percentage and gestational age, significantly greater transmission risk was observed with hard drug use among women with membrane rupture > 4 h. Conclusions: On the basis of self-report and urine toxicology, overall maternal hard drug use and cocaine use in the WITS cohort were associated with maternal HIV culture positivity at delivery, and maternal hard drug use was associated with perinatal transmission.",
keywords = "Gynecology, Obstetrics, Pediatrics, Pregnancy, Prenatal drug use, Risk factors, Vertical HIV transmission, Women",
author = "Rodriguez, {Evelyn M.} and Mofenson, {Lynne M.} and Chang, {Bei Hung} and Rich, {Kenneth C.} and Fowler, {Mary Glenn} and Vincent Smeriglio and Sheldon Landesman and Fox, {Harold E.} and Clemente Diaz and Karen Green and Hanson, {I. Celine}",
year = "1996",
language = "English (US)",
volume = "10",
pages = "273--282",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission

AU - Rodriguez, Evelyn M.

AU - Mofenson, Lynne M.

AU - Chang, Bei Hung

AU - Rich, Kenneth C.

AU - Fowler, Mary Glenn

AU - Smeriglio, Vincent

AU - Landesman, Sheldon

AU - Fox, Harold E.

AU - Diaz, Clemente

AU - Green, Karen

AU - Hanson, I. Celine

PY - 1996

Y1 - 1996

N2 - Objective: To evaluate the relationship of drug use with maternal HIV culture positivity at delivery and perinatal HIV transmission. Design: Multicenter prospective cohort study. Setting: Obstetric and pediatric clinics in five cities in the United States. Participants: Five hundred and thirty HIV-infected pregnant women and their infants. Main outcome measures: Multivariate logistic regression was used to evaluate the association of 'hard drug' use (one or more of the following: cocaine, heroin/opiates, methadone, injecting drug use) assessed by self-report and urine toxicology with positive maternal HIV culture at delivery and perinatal HIV transmission. Results: Forty-two per cent of women used hard drugs during pregnancy. Increased probability of a positive maternal delivery HIV culture was significantly associated with prenatal hard drug use [odds ratio (OR), 3.08] and maternal cocaine use (OR, 2.98) among HIV-infected women with > 29% CD4+ lymphocytes. After adjusting for maternal culture positivity at delivery, CD4+ lymphocyte percentage and gestational age, significantly greater transmission risk was observed with hard drug use among women with membrane rupture > 4 h. Conclusions: On the basis of self-report and urine toxicology, overall maternal hard drug use and cocaine use in the WITS cohort were associated with maternal HIV culture positivity at delivery, and maternal hard drug use was associated with perinatal transmission.

AB - Objective: To evaluate the relationship of drug use with maternal HIV culture positivity at delivery and perinatal HIV transmission. Design: Multicenter prospective cohort study. Setting: Obstetric and pediatric clinics in five cities in the United States. Participants: Five hundred and thirty HIV-infected pregnant women and their infants. Main outcome measures: Multivariate logistic regression was used to evaluate the association of 'hard drug' use (one or more of the following: cocaine, heroin/opiates, methadone, injecting drug use) assessed by self-report and urine toxicology with positive maternal HIV culture at delivery and perinatal HIV transmission. Results: Forty-two per cent of women used hard drugs during pregnancy. Increased probability of a positive maternal delivery HIV culture was significantly associated with prenatal hard drug use [odds ratio (OR), 3.08] and maternal cocaine use (OR, 2.98) among HIV-infected women with > 29% CD4+ lymphocytes. After adjusting for maternal culture positivity at delivery, CD4+ lymphocyte percentage and gestational age, significantly greater transmission risk was observed with hard drug use among women with membrane rupture > 4 h. Conclusions: On the basis of self-report and urine toxicology, overall maternal hard drug use and cocaine use in the WITS cohort were associated with maternal HIV culture positivity at delivery, and maternal hard drug use was associated with perinatal transmission.

KW - Gynecology

KW - Obstetrics

KW - Pediatrics

KW - Pregnancy

KW - Prenatal drug use

KW - Risk factors

KW - Vertical HIV transmission

KW - Women

UR - http://www.scopus.com/inward/record.url?scp=9044250488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9044250488&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 273

EP - 282

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 3

ER -