Association of Marijuana Use with Changes in Cognitive Processing Speed and Flexibility for 17 Years in HIV-Seropositive and HIV-Seronegative Men

Chukwuemeka N. Okafor, Michael W. Plankey, Michael Li, Xinguang Chen, Pamela Surkan, Steve Shoptaw, Eileen Martin, Ronald Cohen, Ned Sacktor, Robert L. Cook

Research output: Contribution to journalArticle

Abstract

Background: The long-term effects of marijuana on cognition, particularly in the context of HIV is not clear, as extant research shows mixed findings. Objective: To determine associations between current and cumulative exposure to marijuana and changes in cognitive processing speed and flexibility in 788 HIV-seropositive (HIV+) and 1,132 HIV-seronegative (HIV−) men followed for up to 17 years in the Multicenter AIDS Cohort Study. Results: Among HIV+ men only, current daily marijuana use compared to none-use, was significantly associated with a greater annual percentage decline in cognitive processing speed assessed with the Trail Making Test A (TMTA) (β=−0.41, 95% confidence interval (CI): −0.88, −0.03, p=0.03)] and Symbol Digit Modalities Test (SDMT) (β= −0.14, 95% CI: −0.28, −0.01, p=0.04). Further, monthly marijuana use was associated with greater annual percentage decline in cognitive flexibility assessed with the Trail Making Test B (TMTB) (β= −0.70, 95% CI: −1.34, −0.05; p=0.03] and cognitive processing speed (SDMT) (β= −0.21, 95% CI: −0.40, −0.01, p=0.03). Among the HIV− men only, each 5-marijuana use-years (equivalent to 5-years of daily marijuana use) was significantly associated with a 0.17 annual percentage decline in cognitive processing speed only (TMTA) (β= −0.18, 95% CI: −0.36, −0.01; p=0.04). Conclusions: Our findings suggest that marijuana use, particularly current use, may be associated with worse cognitive processing speed, but the magnitude of the estimates was not clinically meaningful.

Original languageEnglish (US)
JournalSubstance Use and Misuse
DOIs
StatePublished - Jan 1 2019

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Cannabis
flexibility
confidence
HIV
Trail Making Test
Confidence Intervals
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cognition
AIDS
Cognition
HIV-1
Acquired Immunodeficiency Syndrome
Cohort Studies
Research
Cognitive Dysfunction

Keywords

  • cognition
  • HIV
  • longitudinal
  • Marijuana

ASJC Scopus subject areas

  • Health(social science)
  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health

Cite this

Association of Marijuana Use with Changes in Cognitive Processing Speed and Flexibility for 17 Years in HIV-Seropositive and HIV-Seronegative Men. / Okafor, Chukwuemeka N.; Plankey, Michael W.; Li, Michael; Chen, Xinguang; Surkan, Pamela; Shoptaw, Steve; Martin, Eileen; Cohen, Ronald; Sacktor, Ned; Cook, Robert L.

In: Substance Use and Misuse, 01.01.2019.

Research output: Contribution to journalArticle

Okafor, Chukwuemeka N. ; Plankey, Michael W. ; Li, Michael ; Chen, Xinguang ; Surkan, Pamela ; Shoptaw, Steve ; Martin, Eileen ; Cohen, Ronald ; Sacktor, Ned ; Cook, Robert L. / Association of Marijuana Use with Changes in Cognitive Processing Speed and Flexibility for 17 Years in HIV-Seropositive and HIV-Seronegative Men. In: Substance Use and Misuse. 2019.
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abstract = "Background: The long-term effects of marijuana on cognition, particularly in the context of HIV is not clear, as extant research shows mixed findings. Objective: To determine associations between current and cumulative exposure to marijuana and changes in cognitive processing speed and flexibility in 788 HIV-seropositive (HIV+) and 1,132 HIV-seronegative (HIV−) men followed for up to 17 years in the Multicenter AIDS Cohort Study. Results: Among HIV+ men only, current daily marijuana use compared to none-use, was significantly associated with a greater annual percentage decline in cognitive processing speed assessed with the Trail Making Test A (TMTA) (β=−0.41, 95{\%} confidence interval (CI): −0.88, −0.03, p=0.03)] and Symbol Digit Modalities Test (SDMT) (β= −0.14, 95{\%} CI: −0.28, −0.01, p=0.04). Further, monthly marijuana use was associated with greater annual percentage decline in cognitive flexibility assessed with the Trail Making Test B (TMTB) (β= −0.70, 95{\%} CI: −1.34, −0.05; p=0.03] and cognitive processing speed (SDMT) (β= −0.21, 95{\%} CI: −0.40, −0.01, p=0.03). Among the HIV− men only, each 5-marijuana use-years (equivalent to 5-years of daily marijuana use) was significantly associated with a 0.17 annual percentage decline in cognitive processing speed only (TMTA) (β= −0.18, 95{\%} CI: −0.36, −0.01; p=0.04). Conclusions: Our findings suggest that marijuana use, particularly current use, may be associated with worse cognitive processing speed, but the magnitude of the estimates was not clinically meaningful.",
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AU - Okafor, Chukwuemeka N.

AU - Plankey, Michael W.

AU - Li, Michael

AU - Chen, Xinguang

AU - Surkan, Pamela

AU - Shoptaw, Steve

AU - Martin, Eileen

AU - Cohen, Ronald

AU - Sacktor, Ned

AU - Cook, Robert L.

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