Association of macrophage inflammation biomarkers with progression of subclinical carotid artery atherosclerosis in HIV-infected women and men

David B. Hanna, Juan Lin, Wendy S Post, Howard N. Hodis, Xiaonan Xue, Kathryn Anastos, Mardge H. Cohen, Stephen J Gange, Sabina Haberlen, Sonya L. Heath, Jason M. Lazar, Chenglong Liu, Wendy J. Mack, Igho Ofotokun, Frank J. Palella, Phyllis C. Tien, Mallory D. Witt, Alan L. Landay, Lawrence A. Kingsley, Russell P. Tracy & 1 others Robert C. Kaplan

Research output: Contribution to journalArticle

Abstract

Background. Monocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation and vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection. Methods. We examined 778 women (74% HIV+) in the Women's Interagency HIV Study and 503 men (65% HIV+) in the Multicenter AIDS Cohort Study who underwent repeated B-mode carotid artery ultrasound imaging in 2004-2013. We assessed baseline associations of the serum macrophage inflammation markers soluble (s)CD163, sCD14, galectin-3 (Gal-3), and Gal-3 binding protein (Gal-3BP) with carotid plaque formation (focal intima-media thickness >1.5 mm) over 7 years. Results. Marker levels were higher in HIV+ persons versus HIV- persons. Presence of focal plaque increased over time: From 8% to 15% in women, and 24% to 34% in men. After adjustment for demographic, behavioral, and cardiometabolic factors, and CRP and interleukin-6, each standard deviation increase in sCD14 was associated with increased plaque formation (risk ratio [RR] 1.24, 95% confidence interval [CI] 1.07-1.43). This pattern was consistentby sex. sCD163 was associated with plaque formation in virally suppressed HIV+ men (RR 1.52, 95% CI 1.04-2.22); Gal-3BP and Gal-3 were not associated with increased plaque. Conclusions. sCD14 and sCD163 may play important roles in atherogenesis among HIV+ persons.

Original languageEnglish (US)
Pages (from-to)1352-1361
Number of pages10
JournalJournal of Infectious Diseases
Volume215
Issue number9
DOIs
StatePublished - 2017

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Carotid Artery Diseases
Carotid Arteries
Biomarkers
Macrophages
HIV
Inflammation
Galectin 3
Atherosclerosis
Carrier Proteins
Odds Ratio
Confidence Intervals
Virus Diseases
Monocytes
Interleukin-6
Ultrasonography
Acquired Immunodeficiency Syndrome
Cohort Studies
Demography
Serum

Keywords

  • atherosclerosis
  • galectin-3
  • galectin-3 binding protein
  • HIV infection
  • inflammation
  • intima-media thickness
  • macrophages
  • monocytes
  • soluble CD14
  • soluble CD163

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Association of macrophage inflammation biomarkers with progression of subclinical carotid artery atherosclerosis in HIV-infected women and men. / Hanna, David B.; Lin, Juan; Post, Wendy S; Hodis, Howard N.; Xue, Xiaonan; Anastos, Kathryn; Cohen, Mardge H.; Gange, Stephen J; Haberlen, Sabina; Heath, Sonya L.; Lazar, Jason M.; Liu, Chenglong; Mack, Wendy J.; Ofotokun, Igho; Palella, Frank J.; Tien, Phyllis C.; Witt, Mallory D.; Landay, Alan L.; Kingsley, Lawrence A.; Tracy, Russell P.; Kaplan, Robert C.

In: Journal of Infectious Diseases, Vol. 215, No. 9, 2017, p. 1352-1361.

Research output: Contribution to journalArticle

Hanna, DB, Lin, J, Post, WS, Hodis, HN, Xue, X, Anastos, K, Cohen, MH, Gange, SJ, Haberlen, S, Heath, SL, Lazar, JM, Liu, C, Mack, WJ, Ofotokun, I, Palella, FJ, Tien, PC, Witt, MD, Landay, AL, Kingsley, LA, Tracy, RP & Kaplan, RC 2017, 'Association of macrophage inflammation biomarkers with progression of subclinical carotid artery atherosclerosis in HIV-infected women and men', Journal of Infectious Diseases, vol. 215, no. 9, pp. 1352-1361. https://doi.org/10.1093/infdis/jix082
Hanna, David B. ; Lin, Juan ; Post, Wendy S ; Hodis, Howard N. ; Xue, Xiaonan ; Anastos, Kathryn ; Cohen, Mardge H. ; Gange, Stephen J ; Haberlen, Sabina ; Heath, Sonya L. ; Lazar, Jason M. ; Liu, Chenglong ; Mack, Wendy J. ; Ofotokun, Igho ; Palella, Frank J. ; Tien, Phyllis C. ; Witt, Mallory D. ; Landay, Alan L. ; Kingsley, Lawrence A. ; Tracy, Russell P. ; Kaplan, Robert C. / Association of macrophage inflammation biomarkers with progression of subclinical carotid artery atherosclerosis in HIV-infected women and men. In: Journal of Infectious Diseases. 2017 ; Vol. 215, No. 9. pp. 1352-1361.
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abstract = "Background. Monocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation and vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection. Methods. We examined 778 women (74{\%} HIV+) in the Women's Interagency HIV Study and 503 men (65{\%} HIV+) in the Multicenter AIDS Cohort Study who underwent repeated B-mode carotid artery ultrasound imaging in 2004-2013. We assessed baseline associations of the serum macrophage inflammation markers soluble (s)CD163, sCD14, galectin-3 (Gal-3), and Gal-3 binding protein (Gal-3BP) with carotid plaque formation (focal intima-media thickness >1.5 mm) over 7 years. Results. Marker levels were higher in HIV+ persons versus HIV- persons. Presence of focal plaque increased over time: From 8{\%} to 15{\%} in women, and 24{\%} to 34{\%} in men. After adjustment for demographic, behavioral, and cardiometabolic factors, and CRP and interleukin-6, each standard deviation increase in sCD14 was associated with increased plaque formation (risk ratio [RR] 1.24, 95{\%} confidence interval [CI] 1.07-1.43). This pattern was consistentby sex. sCD163 was associated with plaque formation in virally suppressed HIV+ men (RR 1.52, 95{\%} CI 1.04-2.22); Gal-3BP and Gal-3 were not associated with increased plaque. Conclusions. sCD14 and sCD163 may play important roles in atherogenesis among HIV+ persons.",
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T1 - Association of macrophage inflammation biomarkers with progression of subclinical carotid artery atherosclerosis in HIV-infected women and men

AU - Hanna, David B.

AU - Lin, Juan

AU - Post, Wendy S

AU - Hodis, Howard N.

AU - Xue, Xiaonan

AU - Anastos, Kathryn

AU - Cohen, Mardge H.

AU - Gange, Stephen J

AU - Haberlen, Sabina

AU - Heath, Sonya L.

AU - Lazar, Jason M.

AU - Liu, Chenglong

AU - Mack, Wendy J.

AU - Ofotokun, Igho

AU - Palella, Frank J.

AU - Tien, Phyllis C.

AU - Witt, Mallory D.

AU - Landay, Alan L.

AU - Kingsley, Lawrence A.

AU - Tracy, Russell P.

AU - Kaplan, Robert C.

PY - 2017

Y1 - 2017

N2 - Background. Monocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation and vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection. Methods. We examined 778 women (74% HIV+) in the Women's Interagency HIV Study and 503 men (65% HIV+) in the Multicenter AIDS Cohort Study who underwent repeated B-mode carotid artery ultrasound imaging in 2004-2013. We assessed baseline associations of the serum macrophage inflammation markers soluble (s)CD163, sCD14, galectin-3 (Gal-3), and Gal-3 binding protein (Gal-3BP) with carotid plaque formation (focal intima-media thickness >1.5 mm) over 7 years. Results. Marker levels were higher in HIV+ persons versus HIV- persons. Presence of focal plaque increased over time: From 8% to 15% in women, and 24% to 34% in men. After adjustment for demographic, behavioral, and cardiometabolic factors, and CRP and interleukin-6, each standard deviation increase in sCD14 was associated with increased plaque formation (risk ratio [RR] 1.24, 95% confidence interval [CI] 1.07-1.43). This pattern was consistentby sex. sCD163 was associated with plaque formation in virally suppressed HIV+ men (RR 1.52, 95% CI 1.04-2.22); Gal-3BP and Gal-3 were not associated with increased plaque. Conclusions. sCD14 and sCD163 may play important roles in atherogenesis among HIV+ persons.

AB - Background. Monocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation and vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection. Methods. We examined 778 women (74% HIV+) in the Women's Interagency HIV Study and 503 men (65% HIV+) in the Multicenter AIDS Cohort Study who underwent repeated B-mode carotid artery ultrasound imaging in 2004-2013. We assessed baseline associations of the serum macrophage inflammation markers soluble (s)CD163, sCD14, galectin-3 (Gal-3), and Gal-3 binding protein (Gal-3BP) with carotid plaque formation (focal intima-media thickness >1.5 mm) over 7 years. Results. Marker levels were higher in HIV+ persons versus HIV- persons. Presence of focal plaque increased over time: From 8% to 15% in women, and 24% to 34% in men. After adjustment for demographic, behavioral, and cardiometabolic factors, and CRP and interleukin-6, each standard deviation increase in sCD14 was associated with increased plaque formation (risk ratio [RR] 1.24, 95% confidence interval [CI] 1.07-1.43). This pattern was consistentby sex. sCD163 was associated with plaque formation in virally suppressed HIV+ men (RR 1.52, 95% CI 1.04-2.22); Gal-3BP and Gal-3 were not associated with increased plaque. Conclusions. sCD14 and sCD163 may play important roles in atherogenesis among HIV+ persons.

KW - atherosclerosis

KW - galectin-3

KW - galectin-3 binding protein

KW - HIV infection

KW - inflammation

KW - intima-media thickness

KW - macrophages

KW - monocytes

KW - soluble CD14

KW - soluble CD163

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DO - 10.1093/infdis/jix082

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JF - Journal of Infectious Diseases

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