TY - JOUR
T1 - Association of low vitamin D levels with the frailty syndrome in men and women
AU - Shardell, Michelle
AU - Hicks, Gregory E.
AU - Miller, Ram R.
AU - Kritchevsky, Stephen
AU - Andersen, Daniel
AU - Bandinelli, Stefania
AU - Cherubini, Antonio
AU - Ferrucci, Luigi
PY - 2009/1
Y1 - 2009/1
N2 - Background. Although both vitamin D (25-hydroxyvitamin D [25(OH)D]) insufficiency and the frailty syndrome are more prevalent in women than men, sex-specific associations have not been explored. We estimated sex-specific associations of low 25(OH)D with frailty. Vitamin D insufficiency can result in hyperparathyroidism, and thus, parathyroid hormone (PTH) was explored as a potential mediator in the relationship between 25(OH)D levels and frailty. Methods. The sample included 444 male and 561 female participants aged 65 years and older from the InCHIANTI study for whom 25(OH)D levels and frailty information were available. Frailty was defined as the presence of at least three of the five following criteria: slowness, weakness, low energy expenditure, exhaustion, and weight loss. Logistic regression models estimated the association between serum levels of 25(OH)D and PTH with frailty, controlling for potential confounders. Results. Independent of covariates, men with 25(OH)D
AB - Background. Although both vitamin D (25-hydroxyvitamin D [25(OH)D]) insufficiency and the frailty syndrome are more prevalent in women than men, sex-specific associations have not been explored. We estimated sex-specific associations of low 25(OH)D with frailty. Vitamin D insufficiency can result in hyperparathyroidism, and thus, parathyroid hormone (PTH) was explored as a potential mediator in the relationship between 25(OH)D levels and frailty. Methods. The sample included 444 male and 561 female participants aged 65 years and older from the InCHIANTI study for whom 25(OH)D levels and frailty information were available. Frailty was defined as the presence of at least three of the five following criteria: slowness, weakness, low energy expenditure, exhaustion, and weight loss. Logistic regression models estimated the association between serum levels of 25(OH)D and PTH with frailty, controlling for potential confounders. Results. Independent of covariates, men with 25(OH)D
KW - Frailty syndrome
KW - InCHIANTI
KW - Parathyroid hormone
KW - Vitamin D
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U2 - 10.1093/gerona/gln007
DO - 10.1093/gerona/gln007
M3 - Article
C2 - 19164273
AN - SCOPUS:64249121794
SN - 1079-5006
VL - 64
SP - 69
EP - 75
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 1
ER -