TY - JOUR
T1 - Association of lipid-related genetic variants with the incidence of atrial fibrillation
T2 - The AFGen consortium
AU - Norby, Faye L.
AU - Eryd, Samuel Adamsson
AU - Niemeijer, Maartje N.
AU - Rose, Lynda M.
AU - Smith, Albert V.
AU - Yin, Xiaoyan
AU - Agarwal, Sunil K.
AU - Arking, Dan E.
AU - Chasman, Daniel L.
AU - Chen, Lin Y.
AU - Eijgelsheim, Mark
AU - Engström, Gunnar
AU - Franco, Oscar H.
AU - Heeringa, Jan
AU - Hindy, George
AU - Hofman, Albert
AU - Lutsey, Pamela L.
AU - Magnani, Jared W.
AU - McManus, David D.
AU - Orho-Melander, Marju
AU - Pankow, James S.
AU - Rukh, Gull
AU - Schulz, Christina Alexandra
AU - Uitterlinden, André G.
AU - Albert, Christine M.
AU - Benjamin, Emelia J.
AU - Gudnason, Vilmundur
AU - Smith, J. Gustav
AU - Stricker, Bruno H.C.
AU - Alonso, Alvaro
N1 - Publisher Copyright:
© 2016 Norby et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in anymedium, provided the original author and source are credited.
PY - 2016/3
Y1 - 2016/3
N2 - Background: Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts. Methods: We analyzed 64,901 individuals of European ancestry without previous AF at baseline and with lipid gene scores. Lipid-specific gene scores, based on loci significantly associated with lipid levels, were calculated. Additionally, non-pleiotropic gene scores for high-density lipoprotein cholesterol (HDLc) and low-density lipoprotein cholesterol (LDLc) were calculated using SNPs that were only associated with the specific lipid fraction. Cox models were used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) of AF per 1-standard deviation (SD) increase of each lipid gene score. Results: During a mean follow-up of 12.0 years, 5434 (8.4%) incident AF cases were identified. After meta-analysis, the HDLc, LDLc, total cholesterol, and triglyceride gene scores were not associated with incidence of AF. Multivariable-adjusted HR (95% CI) were 1.01 (0.98-1.03); 0.98 (0.96-1.01); 0.98 (0.95-1.02); 0.99 (0.97-1.02), respectively. Similarly, non-pleiotropic HDLc and LDLc gene scores showed no association with incident AF: HR (95% CI) = 1.00 (0.97-1.03); 1.01 (0.99-1.04). Conclusions In this large cohort study of individuals of European ancestry, gene scores for lipid fractions were not associated with incident AF.
AB - Background: Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts. Methods: We analyzed 64,901 individuals of European ancestry without previous AF at baseline and with lipid gene scores. Lipid-specific gene scores, based on loci significantly associated with lipid levels, were calculated. Additionally, non-pleiotropic gene scores for high-density lipoprotein cholesterol (HDLc) and low-density lipoprotein cholesterol (LDLc) were calculated using SNPs that were only associated with the specific lipid fraction. Cox models were used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) of AF per 1-standard deviation (SD) increase of each lipid gene score. Results: During a mean follow-up of 12.0 years, 5434 (8.4%) incident AF cases were identified. After meta-analysis, the HDLc, LDLc, total cholesterol, and triglyceride gene scores were not associated with incidence of AF. Multivariable-adjusted HR (95% CI) were 1.01 (0.98-1.03); 0.98 (0.96-1.01); 0.98 (0.95-1.02); 0.99 (0.97-1.02), respectively. Similarly, non-pleiotropic HDLc and LDLc gene scores showed no association with incident AF: HR (95% CI) = 1.00 (0.97-1.03); 1.01 (0.99-1.04). Conclusions In this large cohort study of individuals of European ancestry, gene scores for lipid fractions were not associated with incident AF.
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U2 - 10.1371/journal.pone.0151932
DO - 10.1371/journal.pone.0151932
M3 - Article
C2 - 26999784
AN - SCOPUS:84962158404
SN - 1932-6203
VL - 11
JO - PloS one
JF - PloS one
IS - 3
M1 - e0151932
ER -