Association of IgE with reaginic activity in sera from grass pollen- and horse dander-sensitive individuals

O. L. Frick, K. Ishizaka

Research output: Contribution to journalArticlepeer-review

Abstract

Immunoglobulin E is associated with reagin-rich chromatographic fractions in sera of patients sensitive to rye grass pollen and to horse dander. Thus, in a patient (W. G.) who is sensitive to both allergens, the peak reaginic activity to both allergens was associated with IgE antibody. Absorption of reagin-rich fractions with anti-IgE serum removed reagins to several allergens upon passive transfer (P-K) testing. The inactivation of reagins and probably IgE upon treatment with thiols or heat was confirmed.

Original languageEnglish (US)
Pages (from-to)220-233
Number of pages14
JournalJournal of Allergy
Volume45
Issue number4
DOIs
StatePublished - Apr 1970

ASJC Scopus subject areas

  • Medicine(all)

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