TY - JOUR
T1 - Association of human papillomavirus with nasal neoplasia
AU - Wu, T. C.
AU - Trujillo, J. M.
AU - Mounts, P.
AU - Kashima, H. K.
N1 - Funding Information:
Peden for critical reading of the manuscript. Supported by grants from the National Institute of Health and American Cancer Society.
Funding Information:
K. P. C. is an investigator of the Howard Hughes Medical Institute. This work was also supported by the Muscular Dystrophy Association of America and the Uehara Memorial Foundation. We thank Cynthia J. Leveille and Michael J. Mullinix for technical assistance.
PY - 1993/2/27
Y1 - 1993/2/27
N2 - Since HPV-57b has been identified by two different techniques in benign, premalignant, and malignant lesions of the nasal cavity, but not in cases of chronic sinusitis, H PV-57 should be recognised as at least a co-factor in the aetiology of nasal neoplasia. Paraffin sections of 22 histologically confirmed nasal tumours were screened by in-situ hybridisation with riboprobes specific for HPV-57b. Virus was demonstrated in 6 of 7 fungiform papillomas, 6 of 8 inverted papillomas, 1 of 3 inverted papillomas with dysplasia, and 2 of 4 inverted papillomas with carcinoma. The presence of HPV-57b was confirmed with the polymerase chain reaction, which identified an additional 4 positive samples, bringing the total to 86% positive specimens. The results underscore the importance of HPVs in the aetiology of cancers at extragenital sites.
AB - Since HPV-57b has been identified by two different techniques in benign, premalignant, and malignant lesions of the nasal cavity, but not in cases of chronic sinusitis, H PV-57 should be recognised as at least a co-factor in the aetiology of nasal neoplasia. Paraffin sections of 22 histologically confirmed nasal tumours were screened by in-situ hybridisation with riboprobes specific for HPV-57b. Virus was demonstrated in 6 of 7 fungiform papillomas, 6 of 8 inverted papillomas, 1 of 3 inverted papillomas with dysplasia, and 2 of 4 inverted papillomas with carcinoma. The presence of HPV-57b was confirmed with the polymerase chain reaction, which identified an additional 4 positive samples, bringing the total to 86% positive specimens. The results underscore the importance of HPVs in the aetiology of cancers at extragenital sites.
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U2 - 10.1016/0140-6736(93)90280-T
DO - 10.1016/0140-6736(93)90280-T
M3 - Article
C2 - 8094773
AN - SCOPUS:0027475673
SN - 0140-6736
VL - 341
SP - 522
EP - 524
JO - The Lancet
JF - The Lancet
IS - 8844
ER -