TY - JOUR
T1 - Association of hip bone mineral density and body composition in a rural indian population
T2 - The Andhra Pradesh children and parents study (APCAPS)
AU - Matsuzaki, Mika
AU - Kulkarni, Bharati
AU - Kuper, Hannah
AU - Wells, Jonathan C.
AU - Ploubidis, George B.
AU - Prabhakaran, Poornima
AU - Gupta, Vipin
AU - Walia, Gagandeep Kaur
AU - Aggarwal, Aastha
AU - Prabhakaran, Dorairaj
AU - Smith, George Davey
AU - Radhakrishna, Kankipati Vijaya
AU - Ben-Shlomo, Yoav
AU - Kinra, Sanjay
N1 - Funding Information:
We thank our dedicated field teams led by Santhi Bogadi and the study participants who made this study possible. GDS’ work is supported by the Medical Research Council and the University of Bristol MC_UU_12013/1-9.
Publisher Copyright:
© 2017 Matsuzaki et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, andreproduction in any medium, provided the originalauthor and source are credited.
PY - 2017/1
Y1 - 2017/1
N2 - Background: Fat mass is variably associated with bone mass, possibly due to differential mechanical and biological effects of fat mass. We examined the association of fat mass with bone mass in a lean population. Objective: To investigate association between hip bone mineral density and fat and lean mass in a cross-sectional study from southern India. Design: The Andhra Pradesh Children and Parents Study is a prospective cohort study in Hyderabad, India. In 2009-2012, the study collected data on anthropometric measures, bone mineral density (BMD), fat mass, and lean mass measured by dual-energy x-ray absorptiometry, and socioeconomic data of the adult participants (n = 1760; mean age = 34.9 years old for women; 2130 and 32.3 for men). Results: The median BMI (kg/m2) was 20.1 kg/m2. Women had relatively higher fat mass as compared to men. In models adjusted for lean mass, there was an association between hip bone mineral density and fat mass in women (β (95% confidence interval): premenopausal 0.025 (0.006 to 0.045); postmenopausal 0.045 (0.014 to 0.076)) but not in men (0.001 (-0.012 to 0.0014)). The association between hip BMD and fat mass was stronger in postmenopausal than premenopausal women. Hip BMD was consistently associated with lean mass, in both men and women. Conclusions: In this relatively lean population, lean mass was more consistently associated with hip BMD than fat mass. Weight gain through lean mass improvement may be a more reliable public health strategy for strengthening bone health in transitional settings.
AB - Background: Fat mass is variably associated with bone mass, possibly due to differential mechanical and biological effects of fat mass. We examined the association of fat mass with bone mass in a lean population. Objective: To investigate association between hip bone mineral density and fat and lean mass in a cross-sectional study from southern India. Design: The Andhra Pradesh Children and Parents Study is a prospective cohort study in Hyderabad, India. In 2009-2012, the study collected data on anthropometric measures, bone mineral density (BMD), fat mass, and lean mass measured by dual-energy x-ray absorptiometry, and socioeconomic data of the adult participants (n = 1760; mean age = 34.9 years old for women; 2130 and 32.3 for men). Results: The median BMI (kg/m2) was 20.1 kg/m2. Women had relatively higher fat mass as compared to men. In models adjusted for lean mass, there was an association between hip bone mineral density and fat mass in women (β (95% confidence interval): premenopausal 0.025 (0.006 to 0.045); postmenopausal 0.045 (0.014 to 0.076)) but not in men (0.001 (-0.012 to 0.0014)). The association between hip BMD and fat mass was stronger in postmenopausal than premenopausal women. Hip BMD was consistently associated with lean mass, in both men and women. Conclusions: In this relatively lean population, lean mass was more consistently associated with hip BMD than fat mass. Weight gain through lean mass improvement may be a more reliable public health strategy for strengthening bone health in transitional settings.
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U2 - 10.1371/journal.pone.0167114
DO - 10.1371/journal.pone.0167114
M3 - Article
C2 - 28060826
AN - SCOPUS:85009210500
SN - 1932-6203
VL - 12
JO - PloS one
JF - PloS one
IS - 1
M1 - 0167114
ER -