Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia, 2014

Daniel R. Feikin, Basem Alraddadi, Mohammed Qutub, Omaima Shabouni, Aaron Curns, Ikwo K. Oboho, Sara M. Tomczyk, Bernard Wolff, John T. Watson, Tariq A. Madani

Research output: Contribution to journalArticle

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) causes a spectrum of illness. We evaluated whether cycle threshold (Ct) values (which are inversely related to virus load) were associated with clinical severity in patients from Saudi Arabia whose nasopharyngeal specimens tested positive for this virus by real-time reverse transcription PCR. Among 102 patients, median Ct of 31.0 for the upstream of the E gene target for 41 (40%) patients who died was significantly lower than the median of 33.0 for 61 survivors (p = 0.0087). In multivariable regression analyses, risk factors for death were age >60 years), underlying illness, and decreasing Ct). Results were similar for a composite severe outcome (death and/or intensive care unit admission). More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes.

Original languageEnglish (US)
Pages (from-to)2029-2035
Number of pages7
JournalEmerging infectious diseases
Volume21
Issue number11
DOIs
StatePublished - Nov 2015
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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    Feikin, D. R., Alraddadi, B., Qutub, M., Shabouni, O., Curns, A., Oboho, I. K., Tomczyk, S. M., Wolff, B., Watson, J. T., & Madani, T. A. (2015). Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia, 2014. Emerging infectious diseases, 21(11), 2029-2035. https://doi.org/10.3201/eid2111.150764