Association of haplotypes in the β-chemokine locus with multiple sclerosis

Tamara Vyshkina, Yin Yao Shugart, Gary Birnbaum, Thomas P. Leist, Bernadette Kalman

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Linkage studies in multiple sclerosis (MS) identified several susceptibility loci. One of these regions includes chromosome 17q11 where a meta-analysis of data from three genome scans suggested linkage. This region encodes a cluster of genes for β-chemokines or CC chemokine ligands (CCLs), which may be involved in the development of MS lesions. Here we aimed to test if CCL alleles and haplotypes are associated with MS. Using methods of linkage and association, we observed deviations from the expected 50% transmission of haplotypes from unaffected parents to their affected children at CCL2, CCL11-CCL8-CCL13 and CCL3 within the investigated 1.85 MB chromosomal segment. Analyses of the linkage disequilibrium map support that variants with possible relevance to MS can be located within these subregions. Identification of MS associated CCL variants may have direct clinical significance, as it can lead to the design of small competitive antagonists of these molecules with beneficial effects in the treatment of patients with early and active disease.

Original languageEnglish (US)
Pages (from-to)240-247
Number of pages8
JournalEuropean Journal of Human Genetics
Issue number2
StatePublished - Feb 2005


  • β-chemokines
  • Haplotype
  • Multiple sclerosis
  • SNP
  • Susceptibility

ASJC Scopus subject areas

  • Genetics(clinical)


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