Association of Glyceraldehyde-3-phosphate Dehydrogenase Expression with Cell Motility and Metastatic Potential of Rat Prostatic Adenocarcinoma

Daniel E. Epner; Alan W. artin; Jack A. Schalken; John T. Isaacs; Donald S. Coffey

Association of Glyceraldehyde-3-phosphate Dehydrogenase Expression with Cell Motility and Metastatic Potential of Rat Prostatic Adenocarcinoma

Daniel E. Epner, Alan W. artin, Jack A. Schalken, John T. Isaacs, Donald S. Coffey

School of Medicine

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression is increased in Dunning R-3327 rat prostatic adenocarcinoma cell lines relative to normal rat ventral prostate tissue. GAPDH expression closely correlates with cell motility of Dunning prostate cancer cell lines and accurately distinguishes cell lines with high metastatic potential from those with low metastatic potential. Increased GAPDH expression in the cancer cell lines is not simply related to increased growth rate, since rapidly proliferating normal prostate tissue did not exhibit elevated GAPDH expression.

Original language	English (US)
Pages (from-to)	1995-1997
Number of pages	3
Journal	Cancer Research
Volume	53
Issue number	9
State	Published - May 1993

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Association of Glyceraldehyde-3-phosphate Dehydrogenase Expression with Cell Motility and Metastatic Potential of Rat Prostatic Adenocarcinoma",

abstract = "Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression is increased in Dunning R-3327 rat prostatic adenocarcinoma cell lines relative to normal rat ventral prostate tissue. GAPDH expression closely correlates with cell motility of Dunning prostate cancer cell lines and accurately distinguishes cell lines with high metastatic potential from those with low metastatic potential. Increased GAPDH expression in the cancer cell lines is not simply related to increased growth rate, since rapidly proliferating normal prostate tissue did not exhibit elevated GAPDH expression.",

author = "Epner, {Daniel E.} and artin, {Alan W.} and Schalken, {Jack A.} and Isaacs, {John T.} and Coffey, {Donald S.}",

year = "1993",

month = may,

language = "English (US)",

volume = "53",

pages = "1995--1997",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

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T1 - Association of Glyceraldehyde-3-phosphate Dehydrogenase Expression with Cell Motility and Metastatic Potential of Rat Prostatic Adenocarcinoma

AU - Epner, Daniel E.

AU - artin, Alan W.

AU - Schalken, Jack A.

AU - Isaacs, John T.

AU - Coffey, Donald S.

PY - 1993/5

Y1 - 1993/5

N2 - Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression is increased in Dunning R-3327 rat prostatic adenocarcinoma cell lines relative to normal rat ventral prostate tissue. GAPDH expression closely correlates with cell motility of Dunning prostate cancer cell lines and accurately distinguishes cell lines with high metastatic potential from those with low metastatic potential. Increased GAPDH expression in the cancer cell lines is not simply related to increased growth rate, since rapidly proliferating normal prostate tissue did not exhibit elevated GAPDH expression.

AB - Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression is increased in Dunning R-3327 rat prostatic adenocarcinoma cell lines relative to normal rat ventral prostate tissue. GAPDH expression closely correlates with cell motility of Dunning prostate cancer cell lines and accurately distinguishes cell lines with high metastatic potential from those with low metastatic potential. Increased GAPDH expression in the cancer cell lines is not simply related to increased growth rate, since rapidly proliferating normal prostate tissue did not exhibit elevated GAPDH expression.

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UR - http://www.scopus.com/inward/citedby.url?scp=0027230458&partnerID=8YFLogxK

M3 - Article

C2 - 8481901

AN - SCOPUS:0027230458

SN - 0008-5472

VL - 53

SP - 1995

EP - 1997

JO - Cancer Research

JF - Cancer Research

IS - 9

ER -

Association of Glyceraldehyde-3-phosphate Dehydrogenase Expression with Cell Motility and Metastatic Potential of Rat Prostatic Adenocarcinoma

Abstract

ASJC Scopus subject areas

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