Association of Glyceraldehyde-3-phosphate Dehydrogenase Expression with Cell Motility and Metastatic Potential of Rat Prostatic Adenocarcinoma

Daniel E. Epner, Alan W. artin, Jack A. Schalken, John T. Isaacs, Donald S. Coffey

Research output: Contribution to journalArticle

Abstract

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression is increased in Dunning R-3327 rat prostatic adenocarcinoma cell lines relative to normal rat ventral prostate tissue. GAPDH expression closely correlates with cell motility of Dunning prostate cancer cell lines and accurately distinguishes cell lines with high metastatic potential from those with low metastatic potential. Increased GAPDH expression in the cancer cell lines is not simply related to increased growth rate, since rapidly proliferating normal prostate tissue did not exhibit elevated GAPDH expression.

Original languageEnglish (US)
Pages (from-to)1995-1997
Number of pages3
JournalCancer Research
Volume53
Issue number9
StatePublished - May 1993

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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