Association of Genome-Wide Association Study (GWAS) identified SNPs and risk of breast cancer in an Indian population

Rajini Nagrani, Sharayu Mhatre, Preetha Rajaraman, Nilanjan Chatterjee, Mohammad R. Akbari, Paolo Boffetta, Paul Brennan, Rajendra Badwe, Sudeep Gupta, Rajesh Dikshit

Research output: Contribution to journalArticle

Abstract

To date, no studies have investigated the association of the GWAS-identified SNPs with BC risk in Indian population. We investigated the association of 30 previously reported and replicated BC susceptibility SNPs in 1,204 cases and 1,212 controls from a hospital based case-control study conducted at the Tata Memorial Hospital, Mumbai. As a measure of total susceptibility burden, the polygenic risk score (PRS) for each individual was defined by the weighted sum of genotypes from 21 independent SNPs with weights derived from previously published estimates of association odds-ratios. Logistic regression models were used to assess risk associated with individual SNPs and overall PRS, and stratified by menopausal and receptor status. A total of 11 SNPs from eight genomic regions (FGFR2, 9q31.2, MAP3K, CCND1, ZM1Z1, RAD51L11, ESR1 and UST) showed statistically significant (p-value ≤ 0.05) evidence of association, either overall or when stratified by menopausal status or hormone receptor status. BC SNPs previously identified in Caucasian population showed evidence of replication in the Indian population mainly with respect to risk of postmenopausal and hormone receptor positive BC.

Original languageEnglish (US)
Article number40963
JournalScientific Reports
Volume7
DOIs
StatePublished - Jan 18 2017

Fingerprint

Genome-Wide Association Study
Single Nucleotide Polymorphism
Breast Neoplasms
Population
Logistic Models
Hormones
Case-Control Studies
Odds Ratio
Genotype
Weights and Measures

ASJC Scopus subject areas

  • General

Cite this

Association of Genome-Wide Association Study (GWAS) identified SNPs and risk of breast cancer in an Indian population. / Nagrani, Rajini; Mhatre, Sharayu; Rajaraman, Preetha; Chatterjee, Nilanjan; Akbari, Mohammad R.; Boffetta, Paolo; Brennan, Paul; Badwe, Rajendra; Gupta, Sudeep; Dikshit, Rajesh.

In: Scientific Reports, Vol. 7, 40963, 18.01.2017.

Research output: Contribution to journalArticle

Nagrani, R, Mhatre, S, Rajaraman, P, Chatterjee, N, Akbari, MR, Boffetta, P, Brennan, P, Badwe, R, Gupta, S & Dikshit, R 2017, 'Association of Genome-Wide Association Study (GWAS) identified SNPs and risk of breast cancer in an Indian population', Scientific Reports, vol. 7, 40963. https://doi.org/10.1038/srep40963
Nagrani, Rajini ; Mhatre, Sharayu ; Rajaraman, Preetha ; Chatterjee, Nilanjan ; Akbari, Mohammad R. ; Boffetta, Paolo ; Brennan, Paul ; Badwe, Rajendra ; Gupta, Sudeep ; Dikshit, Rajesh. / Association of Genome-Wide Association Study (GWAS) identified SNPs and risk of breast cancer in an Indian population. In: Scientific Reports. 2017 ; Vol. 7.
@article{975521b710b14b9d9008b95a0802849d,
title = "Association of Genome-Wide Association Study (GWAS) identified SNPs and risk of breast cancer in an Indian population",
abstract = "To date, no studies have investigated the association of the GWAS-identified SNPs with BC risk in Indian population. We investigated the association of 30 previously reported and replicated BC susceptibility SNPs in 1,204 cases and 1,212 controls from a hospital based case-control study conducted at the Tata Memorial Hospital, Mumbai. As a measure of total susceptibility burden, the polygenic risk score (PRS) for each individual was defined by the weighted sum of genotypes from 21 independent SNPs with weights derived from previously published estimates of association odds-ratios. Logistic regression models were used to assess risk associated with individual SNPs and overall PRS, and stratified by menopausal and receptor status. A total of 11 SNPs from eight genomic regions (FGFR2, 9q31.2, MAP3K, CCND1, ZM1Z1, RAD51L11, ESR1 and UST) showed statistically significant (p-value ≤ 0.05) evidence of association, either overall or when stratified by menopausal status or hormone receptor status. BC SNPs previously identified in Caucasian population showed evidence of replication in the Indian population mainly with respect to risk of postmenopausal and hormone receptor positive BC.",
author = "Rajini Nagrani and Sharayu Mhatre and Preetha Rajaraman and Nilanjan Chatterjee and Akbari, {Mohammad R.} and Paolo Boffetta and Paul Brennan and Rajendra Badwe and Sudeep Gupta and Rajesh Dikshit",
year = "2017",
month = "1",
day = "18",
doi = "10.1038/srep40963",
language = "English (US)",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Association of Genome-Wide Association Study (GWAS) identified SNPs and risk of breast cancer in an Indian population

AU - Nagrani, Rajini

AU - Mhatre, Sharayu

AU - Rajaraman, Preetha

AU - Chatterjee, Nilanjan

AU - Akbari, Mohammad R.

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Badwe, Rajendra

AU - Gupta, Sudeep

AU - Dikshit, Rajesh

PY - 2017/1/18

Y1 - 2017/1/18

N2 - To date, no studies have investigated the association of the GWAS-identified SNPs with BC risk in Indian population. We investigated the association of 30 previously reported and replicated BC susceptibility SNPs in 1,204 cases and 1,212 controls from a hospital based case-control study conducted at the Tata Memorial Hospital, Mumbai. As a measure of total susceptibility burden, the polygenic risk score (PRS) for each individual was defined by the weighted sum of genotypes from 21 independent SNPs with weights derived from previously published estimates of association odds-ratios. Logistic regression models were used to assess risk associated with individual SNPs and overall PRS, and stratified by menopausal and receptor status. A total of 11 SNPs from eight genomic regions (FGFR2, 9q31.2, MAP3K, CCND1, ZM1Z1, RAD51L11, ESR1 and UST) showed statistically significant (p-value ≤ 0.05) evidence of association, either overall or when stratified by menopausal status or hormone receptor status. BC SNPs previously identified in Caucasian population showed evidence of replication in the Indian population mainly with respect to risk of postmenopausal and hormone receptor positive BC.

AB - To date, no studies have investigated the association of the GWAS-identified SNPs with BC risk in Indian population. We investigated the association of 30 previously reported and replicated BC susceptibility SNPs in 1,204 cases and 1,212 controls from a hospital based case-control study conducted at the Tata Memorial Hospital, Mumbai. As a measure of total susceptibility burden, the polygenic risk score (PRS) for each individual was defined by the weighted sum of genotypes from 21 independent SNPs with weights derived from previously published estimates of association odds-ratios. Logistic regression models were used to assess risk associated with individual SNPs and overall PRS, and stratified by menopausal and receptor status. A total of 11 SNPs from eight genomic regions (FGFR2, 9q31.2, MAP3K, CCND1, ZM1Z1, RAD51L11, ESR1 and UST) showed statistically significant (p-value ≤ 0.05) evidence of association, either overall or when stratified by menopausal status or hormone receptor status. BC SNPs previously identified in Caucasian population showed evidence of replication in the Indian population mainly with respect to risk of postmenopausal and hormone receptor positive BC.

UR - http://www.scopus.com/inward/record.url?scp=85010070389&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85010070389&partnerID=8YFLogxK

U2 - 10.1038/srep40963

DO - 10.1038/srep40963

M3 - Article

C2 - 28098224

AN - SCOPUS:85010070389

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 40963

ER -