Association of Gag-specific T lymphocyte responses during the early phase of human immunodeficiency virus type 1 infection and lower virus load set point

Deepa S. Patke, Susan J. Langan, Lucy M. Carruth, Sheila M. Keating, Beulah P. Sabundayo, Joseph B. Margolick, Thomas C. Quinn, Robert C. Bollinger

Research output: Contribution to journalArticle

Abstract

T lymphocyte responses to human immunodeficiency virus (HIV) type 1 Gag were measured in 9 patients by interferon-γ enzyme-linked immunospot assay at 3 time points within 12 months of infection. Patients with early recognition of HIV-1 Gag had lower subsequent HIV-1 load set points, as measured during the first 2 years of infection, compared with those of patients with undetectable Gag-specific responses (median, 4.27 vs. 5.05 log10 HIV-1 RNA copies/mL, respectively; P = .028). An inverse correlation existed between the magnitude of the Gag-specific responses and the HIV-1 load set point (r = -0.733; P = .025). Early sustained T lymphocyte responses to HIV-1 Gag may be important for the establishment of virus load set point.

Original languageEnglish (US)
Pages (from-to)1177-1180
Number of pages4
JournalJournal of Infectious Diseases
Volume186
Issue number8
DOIs
StatePublished - Oct 15 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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