Association of Foxp3 regulatory gene expression with graft-versus-host disease

Yuji Miura, Christopher J. Thoburn, Emilie C. Bright, Michele L. Phelps, Tahiro Shin, Elizabeth C. Matsui, William H. Matsui, Sally Arai, Ephraim J. Fuchs, Georgia B. Vogelsang, Richard J. Jones, Allan D. Hess

Research output: Contribution to journalArticle

Abstract

Graft-versus-host disease (GVHD) is characterized by an impairment of mechanisms that underlie the development of immunologic tolerance. Although the cytokine storm associated with GVHD leads to expression of cell surface markers on both effector and regulatory T cells, regulatory CD4+ T cells that play an instrumental role in the maintenance of tolerance appear to uniquely express the Foxp3 transcriptional repressor. Foxp3 mRNA expression was significantly decreased in peripheral blood mononuclear cells from patients with either allogeneic GVHD or autologous GVHD compared with patients without GVHD. Expression of Foxp3 negatively correlated with the severity of GVHD but positively correlated with recent thymic emigrants. The results suggest that defective thymic function contributes to the impaired reconstitution of immune regulatory mechanisms following transplantation. The decrease in regulatory mechanisms after transplantation appears to provide an environment permissive to the development of GVHD.

Original languageEnglish (US)
Pages (from-to)2187-2193
Number of pages7
JournalBlood
Volume104
Issue number7
DOIs
StatePublished - Oct 1 2004

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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  • Cite this

    Miura, Y., Thoburn, C. J., Bright, E. C., Phelps, M. L., Shin, T., Matsui, E. C., Matsui, W. H., Arai, S., Fuchs, E. J., Vogelsang, G. B., Jones, R. J., & Hess, A. D. (2004). Association of Foxp3 regulatory gene expression with graft-versus-host disease. Blood, 104(7), 2187-2193. https://doi.org/10.1182/blood-2004-03-1040