Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis

Multi-ethnic study of atherosclerosis

Dhananjay Vaidya, Moyses Szklo, M. Cushman, P. Holvoet, J. Polak, H. Bahrami, N. S. Jenny, Pamela Ouyang

Research output: Contribution to journalArticle

Abstract

Background/Objectives:A cluster of metabolic abnormalities termed metabolic syndrome (MetS) is associated with vascular endothelial dysfunction and oxidative internal milieu. We examined whether the association of MetS with subclinical atherosclerosis is explained by biomarkers of endothelial damage and oxidative stress.Subjects/Methods:Multi-Ethnic Study of Atherosclerosis (MESA) is a population-based study of 45- to 84-year-old individuals of four US ethnicities without clinical cardiovascular disease. A random sample of 997 MESA participants had data on the following biomarkers: von Willebrand factor, soluble intercellular adhesion molecule-1 (sICAM-1), CD40 ligand (CD40L), soluble thrombomodulin, E-selectin and oxidized LDL (oxLDL). We examined whether the associations of MetS with B-mode ultrasound-defined common and internal carotid intimal-medial thickness (IMT) and coronary artery calcium (CAC) measured using computerized tomography were explained by the biomarkers using multiple regression methods.Results:MetS was associated with higher levels of each of the biomarkers (P0.001, CD40L-suggestive association P0.004), with greater IMT (P0.001), and with greater extent of CAC in those in whom CAC was detectable (P0.01). The association of MetS with measures of subclinical atherosclerosis remained unchanged after adjustment for the biomarkers. After adjusting for MetS, oxLDL was suggestively associated with greater prevalence of detectable CAC (P0.005) and thicker internal carotid IMT (P0.002), whereas sICAM-1was significantly associated with greater prevalence of detectable CAC (P0.001).Conclusions:The association of MetS with subclinical atherosclerosis was independent of its association with biomarkers of endothelial damage and oxidative stress, suggesting that metabolic abnormalities and oxidative endothelial damage may lead to atherosclerotic disease through distinct mechanisms.

Original languageEnglish (US)
Pages (from-to)818-825
Number of pages8
JournalEuropean Journal of Clinical Nutrition
Volume65
Issue number7
DOIs
StatePublished - 2011

Fingerprint

Atherosclerosis
Oxidative Stress
Biomarkers
Tunica Intima
Coronary Vessels
Calcium
CD40 Ligand
Thrombomodulin
E-Selectin
von Willebrand Factor
Intercellular Adhesion Molecule-1
Blood Vessels
Cardiovascular Diseases
Tomography
Population

Keywords

  • biomarkers
  • carotid arteries
  • coronary artery atherosclerosis
  • metabolic syndrome

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis : Multi-ethnic study of atherosclerosis. / Vaidya, Dhananjay; Szklo, Moyses; Cushman, M.; Holvoet, P.; Polak, J.; Bahrami, H.; Jenny, N. S.; Ouyang, Pamela.

In: European Journal of Clinical Nutrition, Vol. 65, No. 7, 2011, p. 818-825.

Research output: Contribution to journalArticle

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AU - Holvoet, P.

AU - Polak, J.

AU - Bahrami, H.

AU - Jenny, N. S.

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