Abstract
Background/Objectives:A cluster of metabolic abnormalities termed metabolic syndrome (MetS) is associated with vascular endothelial dysfunction and oxidative internal milieu. We examined whether the association of MetS with subclinical atherosclerosis is explained by biomarkers of endothelial damage and oxidative stress.Subjects/Methods:Multi-Ethnic Study of Atherosclerosis (MESA) is a population-based study of 45- to 84-year-old individuals of four US ethnicities without clinical cardiovascular disease. A random sample of 997 MESA participants had data on the following biomarkers: von Willebrand factor, soluble intercellular adhesion molecule-1 (sICAM-1), CD40 ligand (CD40L), soluble thrombomodulin, E-selectin and oxidized LDL (oxLDL). We examined whether the associations of MetS with B-mode ultrasound-defined common and internal carotid intimal-medial thickness (IMT) and coronary artery calcium (CAC) measured using computerized tomography were explained by the biomarkers using multiple regression methods.Results:MetS was associated with higher levels of each of the biomarkers (P0.001, CD40L-suggestive association P0.004), with greater IMT (P0.001), and with greater extent of CAC in those in whom CAC was detectable (P0.01). The association of MetS with measures of subclinical atherosclerosis remained unchanged after adjustment for the biomarkers. After adjusting for MetS, oxLDL was suggestively associated with greater prevalence of detectable CAC (P0.005) and thicker internal carotid IMT (P0.002), whereas sICAM-1was significantly associated with greater prevalence of detectable CAC (P0.001).Conclusions:The association of MetS with subclinical atherosclerosis was independent of its association with biomarkers of endothelial damage and oxidative stress, suggesting that metabolic abnormalities and oxidative endothelial damage may lead to atherosclerotic disease through distinct mechanisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 818-825 |
| Number of pages | 8 |
| Journal | European Journal of Clinical Nutrition |
| Volume | 65 |
| Issue number | 7 |
| DOIs | |
| State | Published - 2011 |
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Keywords
- biomarkers
- carotid arteries
- coronary artery atherosclerosis
- metabolic syndrome
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis : Multi-ethnic study of atherosclerosis. / Vaidya, Dhananjay; Szklo, Moyses; Cushman, M.; Holvoet, P.; Polak, J.; Bahrami, H.; Jenny, N. S.; Ouyang, Pamela.
In: European Journal of Clinical Nutrition, Vol. 65, No. 7, 2011, p. 818-825.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis
T2 - Multi-ethnic study of atherosclerosis
AU - Vaidya, Dhananjay
AU - Szklo, Moyses
AU - Cushman, M.
AU - Holvoet, P.
AU - Polak, J.
AU - Bahrami, H.
AU - Jenny, N. S.
AU - Ouyang, Pamela
PY - 2011
Y1 - 2011
N2 - Background/Objectives:A cluster of metabolic abnormalities termed metabolic syndrome (MetS) is associated with vascular endothelial dysfunction and oxidative internal milieu. We examined whether the association of MetS with subclinical atherosclerosis is explained by biomarkers of endothelial damage and oxidative stress.Subjects/Methods:Multi-Ethnic Study of Atherosclerosis (MESA) is a population-based study of 45- to 84-year-old individuals of four US ethnicities without clinical cardiovascular disease. A random sample of 997 MESA participants had data on the following biomarkers: von Willebrand factor, soluble intercellular adhesion molecule-1 (sICAM-1), CD40 ligand (CD40L), soluble thrombomodulin, E-selectin and oxidized LDL (oxLDL). We examined whether the associations of MetS with B-mode ultrasound-defined common and internal carotid intimal-medial thickness (IMT) and coronary artery calcium (CAC) measured using computerized tomography were explained by the biomarkers using multiple regression methods.Results:MetS was associated with higher levels of each of the biomarkers (P0.001, CD40L-suggestive association P0.004), with greater IMT (P0.001), and with greater extent of CAC in those in whom CAC was detectable (P0.01). The association of MetS with measures of subclinical atherosclerosis remained unchanged after adjustment for the biomarkers. After adjusting for MetS, oxLDL was suggestively associated with greater prevalence of detectable CAC (P0.005) and thicker internal carotid IMT (P0.002), whereas sICAM-1was significantly associated with greater prevalence of detectable CAC (P0.001).Conclusions:The association of MetS with subclinical atherosclerosis was independent of its association with biomarkers of endothelial damage and oxidative stress, suggesting that metabolic abnormalities and oxidative endothelial damage may lead to atherosclerotic disease through distinct mechanisms.
AB - Background/Objectives:A cluster of metabolic abnormalities termed metabolic syndrome (MetS) is associated with vascular endothelial dysfunction and oxidative internal milieu. We examined whether the association of MetS with subclinical atherosclerosis is explained by biomarkers of endothelial damage and oxidative stress.Subjects/Methods:Multi-Ethnic Study of Atherosclerosis (MESA) is a population-based study of 45- to 84-year-old individuals of four US ethnicities without clinical cardiovascular disease. A random sample of 997 MESA participants had data on the following biomarkers: von Willebrand factor, soluble intercellular adhesion molecule-1 (sICAM-1), CD40 ligand (CD40L), soluble thrombomodulin, E-selectin and oxidized LDL (oxLDL). We examined whether the associations of MetS with B-mode ultrasound-defined common and internal carotid intimal-medial thickness (IMT) and coronary artery calcium (CAC) measured using computerized tomography were explained by the biomarkers using multiple regression methods.Results:MetS was associated with higher levels of each of the biomarkers (P0.001, CD40L-suggestive association P0.004), with greater IMT (P0.001), and with greater extent of CAC in those in whom CAC was detectable (P0.01). The association of MetS with measures of subclinical atherosclerosis remained unchanged after adjustment for the biomarkers. After adjusting for MetS, oxLDL was suggestively associated with greater prevalence of detectable CAC (P0.005) and thicker internal carotid IMT (P0.002), whereas sICAM-1was significantly associated with greater prevalence of detectable CAC (P0.001).Conclusions:The association of MetS with subclinical atherosclerosis was independent of its association with biomarkers of endothelial damage and oxidative stress, suggesting that metabolic abnormalities and oxidative endothelial damage may lead to atherosclerotic disease through distinct mechanisms.
KW - biomarkers
KW - carotid arteries
KW - coronary artery atherosclerosis
KW - metabolic syndrome
UR - http://www.scopus.com/inward/record.url?scp=85027956237&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027956237&partnerID=8YFLogxK
U2 - 10.1038/ejcn.2011.47
DO - 10.1038/ejcn.2011.47
M3 - Article
VL - 65
SP - 818
EP - 825
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
SN - 0954-3007
IS - 7
ER -