Association of endogenous sex hormones with diabetes and impaired fasting glucose in men: Multi-ethnic study of atherosclerosis

Laura A. Colangelo, Pamela Ouyang, Kiang Liu, Peter Kopp, Sherita Hill Golden, Adrian S. Dobs, Moyses Szklo, Dhananjay Vaidya, Mary Cushman, Susan M. Gapstur

Research output: Contribution to journalArticle


OBJECTIVE - To assess associations of sex hormones with impaired fasting glucose (IFG) and type 2 diabetes in men. RESEARCH DESIGN AND METHODS - A total of 3,156 African American, Non-Hispanic white, Hispanic, and Chinese-American men aged 45-84 years who participated in the baseline visit of the Multi-Ethnic Study of Atherosclerosis (MESA) were included. Odds ratios and 95% CIs for type 2 diabetes and IFG compared with normal fasting glucose for quartiles of hormones were estimated. RESULTS - After adjusting for age, ethnicity, BMI, and waist circumference, IFG and diabetes were associated inversely with total testosterone and sex hormone-binding globulin (SHBG) and positively with estradiol (E2). Dehydroepiandrosterone was positively associated with IFG but not with diabetes. Associations did not differ across ethnic groups. CONCLUSIONS - Regardless of obesity, total testosterone and SHBG were associated inversely and E2 was associated positively with IFG and diabetes in men. Further research is warranted to better understand the underlying biological mechanisms.

Original languageEnglish (US)
Pages (from-to)1049-1051
Number of pages3
JournalDiabetes care
Issue number6
StatePublished - Jun 1 2009


ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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