Association of early left ventricular dysfunction with advanced magnetic resonance white matter and gray matter brain measures

The CARDIA study

Anderson C. Armstrong, Majon Muller, Bharath Ambale-Ventakesh, Michael Halstead, Satoru Kishi, Nick Bryan, Stephen Sidney, Lui´s C.L. Correia, Samuel S. Gidding, Lenore J. Launer, Joao Lima

Research output: Contribution to journalArticle

Abstract

Introduction: Relations between heart failure and clinically manifested stroke are well known, but the associations between heart and brain early abnormalities are not totally clear. Aims: We explore relations of subclinical brain abnormalities with early cardiac dysfunction in a large healthy middle-aged biracial cohort. Methods: The CARDIA study enrolled 5115 young adults aged 18-30 years at baseline (1985-1986). We assessed 719 Caucasian and African American participants of the CARDIA study, with echocardiograms and brain MRI at follow-up year 25 (2010-2011). Echocardiography assessed aortic root diameter; LVEF; circumferential, longitudinal, and radial deformation. Cerebral MRI DTI, and, on a subset, ASL perfusion sequences were used to assess white matter fractional anisotropy and gray matter cerebral blood flow (CBF). Linear regression explored relations between cardiac parameters and cerebral measures, adjusting for anthropometrics, risk factors, and brain constitutional variation. Results: Mean age 50 ± 4 years, SBP 118 ± 15 mm Hg; 60% white, and 48% men. Mean CBF was 46 ± 9 mL/100 g/min, and white matter fractional anisotropy was 0.31 ± 0.02. Worse circumferential deformation and larger aortic root were related to worse white matter fractional anisotropy. Worse radial systolic deformation was related to worse CBF in multivariable models. LVEF did not relate to early brain abnormalities. Conclusions: In spite of no apparent effect of LV ejection fraction, early subclinical cardiac dysfunction and brain abnormalities are present and associated in middle-aged generally healthy individuals.

Original languageEnglish (US)
JournalEchocardiography
DOIs
StateAccepted/In press - 2017

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Left Ventricular Dysfunction
Cerebrovascular Circulation
Magnetic Resonance Spectroscopy
Anisotropy
Brain
African Americans
Echocardiography
Gray Matter
White Matter
Young Adult
Linear Models
Heart Failure
Perfusion
Stroke

Keywords

  • Cardiac strain
  • Cerebrovascular disorders
  • Myocardial dysfunction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Association of early left ventricular dysfunction with advanced magnetic resonance white matter and gray matter brain measures : The CARDIA study. / Armstrong, Anderson C.; Muller, Majon; Ambale-Ventakesh, Bharath; Halstead, Michael; Kishi, Satoru; Bryan, Nick; Sidney, Stephen; Correia, Lui´s C.L.; Gidding, Samuel S.; Launer, Lenore J.; Lima, Joao.

In: Echocardiography, 2017.

Research output: Contribution to journalArticle

Armstrong, AC, Muller, M, Ambale-Ventakesh, B, Halstead, M, Kishi, S, Bryan, N, Sidney, S, Correia, LCL, Gidding, SS, Launer, LJ & Lima, J 2017, 'Association of early left ventricular dysfunction with advanced magnetic resonance white matter and gray matter brain measures: The CARDIA study', Echocardiography. https://doi.org/10.1111/echo.13695
Armstrong, Anderson C. ; Muller, Majon ; Ambale-Ventakesh, Bharath ; Halstead, Michael ; Kishi, Satoru ; Bryan, Nick ; Sidney, Stephen ; Correia, Lui´s C.L. ; Gidding, Samuel S. ; Launer, Lenore J. ; Lima, Joao. / Association of early left ventricular dysfunction with advanced magnetic resonance white matter and gray matter brain measures : The CARDIA study. In: Echocardiography. 2017.
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T2 - The CARDIA study

AU - Armstrong, Anderson C.

AU - Muller, Majon

AU - Ambale-Ventakesh, Bharath

AU - Halstead, Michael

AU - Kishi, Satoru

AU - Bryan, Nick

AU - Sidney, Stephen

AU - Correia, Lui´s C.L.

AU - Gidding, Samuel S.

AU - Launer, Lenore J.

AU - Lima, Joao

PY - 2017

Y1 - 2017

N2 - Introduction: Relations between heart failure and clinically manifested stroke are well known, but the associations between heart and brain early abnormalities are not totally clear. Aims: We explore relations of subclinical brain abnormalities with early cardiac dysfunction in a large healthy middle-aged biracial cohort. Methods: The CARDIA study enrolled 5115 young adults aged 18-30 years at baseline (1985-1986). We assessed 719 Caucasian and African American participants of the CARDIA study, with echocardiograms and brain MRI at follow-up year 25 (2010-2011). Echocardiography assessed aortic root diameter; LVEF; circumferential, longitudinal, and radial deformation. Cerebral MRI DTI, and, on a subset, ASL perfusion sequences were used to assess white matter fractional anisotropy and gray matter cerebral blood flow (CBF). Linear regression explored relations between cardiac parameters and cerebral measures, adjusting for anthropometrics, risk factors, and brain constitutional variation. Results: Mean age 50 ± 4 years, SBP 118 ± 15 mm Hg; 60% white, and 48% men. Mean CBF was 46 ± 9 mL/100 g/min, and white matter fractional anisotropy was 0.31 ± 0.02. Worse circumferential deformation and larger aortic root were related to worse white matter fractional anisotropy. Worse radial systolic deformation was related to worse CBF in multivariable models. LVEF did not relate to early brain abnormalities. Conclusions: In spite of no apparent effect of LV ejection fraction, early subclinical cardiac dysfunction and brain abnormalities are present and associated in middle-aged generally healthy individuals.

AB - Introduction: Relations between heart failure and clinically manifested stroke are well known, but the associations between heart and brain early abnormalities are not totally clear. Aims: We explore relations of subclinical brain abnormalities with early cardiac dysfunction in a large healthy middle-aged biracial cohort. Methods: The CARDIA study enrolled 5115 young adults aged 18-30 years at baseline (1985-1986). We assessed 719 Caucasian and African American participants of the CARDIA study, with echocardiograms and brain MRI at follow-up year 25 (2010-2011). Echocardiography assessed aortic root diameter; LVEF; circumferential, longitudinal, and radial deformation. Cerebral MRI DTI, and, on a subset, ASL perfusion sequences were used to assess white matter fractional anisotropy and gray matter cerebral blood flow (CBF). Linear regression explored relations between cardiac parameters and cerebral measures, adjusting for anthropometrics, risk factors, and brain constitutional variation. Results: Mean age 50 ± 4 years, SBP 118 ± 15 mm Hg; 60% white, and 48% men. Mean CBF was 46 ± 9 mL/100 g/min, and white matter fractional anisotropy was 0.31 ± 0.02. Worse circumferential deformation and larger aortic root were related to worse white matter fractional anisotropy. Worse radial systolic deformation was related to worse CBF in multivariable models. LVEF did not relate to early brain abnormalities. Conclusions: In spite of no apparent effect of LV ejection fraction, early subclinical cardiac dysfunction and brain abnormalities are present and associated in middle-aged generally healthy individuals.

KW - Cardiac strain

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