Association of E484K Spike Protein Mutation With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Vaccinated Persons: Maryland, January-May 2021

Kenneth A. Feder, Ami Patel, Venkata R. Vepachedu, Catherine Dominguez, Eric N. Keller, Liore Klein, Curi Kim, Tim Blood, Judie Hyun, Thelonious W. Williams, Katherine A. Feldman, Heba H. Mostafa, C. Paul Morris, Jacques Ravel, Monique Duwell, David Blythe, Robert Myers

Research output: Contribution to journalArticlepeer-review

Abstract

Among 9048 people infected with SARS-CoV-2 between January and May 2021 in Maryland, in regression-adjusted analysis, SARS-CoV-2 viruses carrying the spike protein mutation E484K were disproportionately prevalent among persons infected after full vaccination against COVID-19 compared with infected persons who were not fully vaccinated (aOR, 1.96; 95% CI: 1.36-2.83).

Original languageEnglish (US)
Pages (from-to)2053-2056
Number of pages4
JournalClinical Infectious Diseases
Volume74
Issue number11
DOIs
StatePublished - Jun 1 2022

Keywords

  • B.1.351
  • COVID-19
  • E484K
  • L452R
  • genomic surveillance

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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