Association of DNA methylation with acute mania and inflammatory markers

Sarven Sabunciyan, Brion Maher, Sabine Bahn, Faith Dickerson, Robert H Yolken

Research output: Contribution to journalArticle

Abstract

In order to determine whether epigenetic changes specific to the manic mood state can be detected in peripheral blood samples we assayed DNA methylation levels genome-wide in serum samples obtained from 20 patients hospitalized for mania and 20 unaffected controls using the Illumina 450K methylation arrays.We identified a methylation locus in the CYP11A1 gene, which is regulated by corticotropin, that is hypo-methylated in individuals hospitalized for mania compared with unaffected controls. DNA methylation levels at this locus appear to be state related as levels in follow-up samples collected from mania patients six months after hospitalization were similar to those observed in controls. In addition, we found that methylation levels at the CYP11A1 locus were significantly correlated with three inflammatory markers in serum in acute mania cases but not in unaffected controls. We conclude that mania is associated with alterations in levels of DNA methylation and inflammatory markers. Since epigenetic markers are potentially malleable, a better understanding of the role of epigenetics may lead to new methods for the prevention and treatment of mood disorders.

Original languageEnglish (US)
Article numbere0132001
JournalPLoS One
Volume10
Issue number7
DOIs
StatePublished - Jul 6 2015

Fingerprint

DNA methylation
DNA Methylation
Bipolar Disorder
epigenetics
methylation
Methylation
Cholesterol Side-Chain Cleavage Enzyme
emotions
blood serum
loci
Epigenomics
Genes
corticotropin
sampling
Adrenocorticotropic Hormone
Blood
genome
blood
Mood Disorders
Hospitalization

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Association of DNA methylation with acute mania and inflammatory markers. / Sabunciyan, Sarven; Maher, Brion; Bahn, Sabine; Dickerson, Faith; Yolken, Robert H.

In: PLoS One, Vol. 10, No. 7, e0132001, 06.07.2015.

Research output: Contribution to journalArticle

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