Association of diamine oxidase and ornithine decarboxylase with maturing cells in rapidly proliferating epithelium

Stephen B. Baylin, Shelley A. Stevens, K. M.Mohamed Shakir

Research output: Contribution to journalArticlepeer-review

Abstract

Diamine oxidase and ornithine decarboxylase activities are shown to have a parallel distribution across rat small intestine mucosa; levels of both enzyme activities are sharply higher in mature cells in the villus tip region than in proliferating cells in the crypt areas. Histidine decarboxylase levels were not measurable in the same cell preparations and aromatic-L-amino-acid decarboxylase activity was distributed in an opposite pattern to diamine oxidase and ornithine decarboxylase. The results suggest that intestinal diamine oxidase could be involved with polyamine metabolism. The new findings for ornithine decarboxylase suggest an in vivo role for polyamines in non-proliferative cells; rat small intestinal mucosa may be an excellent model for investigating the function of polyamines in regenerating cells.

Original languageEnglish (US)
Pages (from-to)415-419
Number of pages5
JournalBBA - General Subjects
Volume541
Issue number3
DOIs
StatePublished - Jul 3 1978

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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