TY - JOUR
T1 - Association of CYP1B1 haplotypes and breast cancer risk in Caucasian women
AU - Huang, Yifan
AU - Trentham-Dietz, Amy
AU - García-Closas, Montserrat
AU - Newcomb, Polly A.
AU - Titus-Ernstoff, Linda
AU - Hampton, John M.
AU - Chanock, Stephen J.
AU - Haines, Jonathan L.
AU - Egan, Kathleen M.
PY - 2009/4
Y1 - 2009/4
N2 - CYP1B1 is a key enzyme involved in estrogen metabolism and may play an important role in the development and progression of breast cancer. In a population-based case-controlst udy, we examined eight CYP1B1 haplotype-tagging single nucleotide polymorphisms in relation to invasive breast cancer risk. Analyses were based on 1,655 cases and 1,470 controls; all women were Caucasian. Among the individual single nucleotide polymorphisms, one (rs9341266) was associated with increased risk of breast cancer (Ptrend = 0.021), although the association was no longer significant after adjusting for multiple tests. A marginally significant haplotype effect was identified (P global = 0.015), with significant associations identified for 2 uncommon haplotypes comprising 4% of the controls.Results suggest that genetic variation in CYP1B1 has at most a minor influence on breast cancer susceptibility among Caucasian women.
AB - CYP1B1 is a key enzyme involved in estrogen metabolism and may play an important role in the development and progression of breast cancer. In a population-based case-controlst udy, we examined eight CYP1B1 haplotype-tagging single nucleotide polymorphisms in relation to invasive breast cancer risk. Analyses were based on 1,655 cases and 1,470 controls; all women were Caucasian. Among the individual single nucleotide polymorphisms, one (rs9341266) was associated with increased risk of breast cancer (Ptrend = 0.021), although the association was no longer significant after adjusting for multiple tests. A marginally significant haplotype effect was identified (P global = 0.015), with significant associations identified for 2 uncommon haplotypes comprising 4% of the controls.Results suggest that genetic variation in CYP1B1 has at most a minor influence on breast cancer susceptibility among Caucasian women.
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U2 - 10.1158/1055-9965.EPI-08-0853
DO - 10.1158/1055-9965.EPI-08-0853
M3 - Article
C2 - 19293312
AN - SCOPUS:66649109388
SN - 1055-9965
VL - 18
SP - 1321
EP - 1323
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 4
ER -