Association of CTLA4 polymorphism with regulatory T cell frequency

Sowsan F. Atabani, Chloe L. Thio, Senad Divanovic, Aurelien Trompette, Yasmine Belkaid, David L. Thomas, Christopher L. Karp

Research output: Contribution to journalArticlepeer-review

Abstract

A common single nucleotide polymorphism in CTLA4 has been linked with susceptibility and outcome in autoimmune and infectious diseases, respectively. Here, we show that this polymorphism is associated with the frequency of CD4+ CD25+ regulatory T cells in healthy human volunteers. We further show that, on a per cell basis, such regulatory T cells appear to be functionally indistinguishable across CTLA4 genotypes. These data implicate CTLA4 in regulatory T cell development, and provide a mechanism to account for the link between polymorphisms at this locus and the biological outcome of adaptive immune responses to self and to pathogens.

Original languageEnglish (US)
Pages (from-to)2157-2162
Number of pages6
JournalEuropean Journal of Immunology
Volume35
Issue number7
DOIs
StatePublished - Jul 2005

Keywords

  • CD4CD25
  • CTLA-4
  • Single nucleotide polymorphism
  • T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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