Association of coronary vessel characteristics with outcome in patients with percutaneous coronary interventions with incomplete revascularization

Edward L. Hannan, Ye Zhong, Peter B. Berger, Alice K. Jacobs, Gary D Walford, Frederick S.K. Ling, Ferdinand J. Venditti, Spencer B. King

Research output: Contribution to journalArticle

Abstract

IMPORTANCE Many studies have compared outcomes for incomplete revascularization (IR) among patients undergoing percutaneous coronary interventions (PCI), but little is known about whether outcomes are related to the nature of the IR. OBJECTIVE To determine whether some coronary vessel characteristics are associated with worse outcomes in patients with PCI with IR. DESIGN, SETTING, AND PARTICIPANTS New York's PCI registrywas used to examine mortality (median follow-up, 3.4 years) as a function of the number of vessels that were incompletely revascularized, the stenosis in those vessels, and whether the proximal left anterior descending artery was incompletely revascularized after controlling for other factors associated with mortality for patients with and without ST-elevationmyocardial infarction (STEMI). This was a multicenter study (all nonfederal PCI hospitals in New York State) that included 41 639 New York residents with multivessel coronary artery disease undergoing PCI in New York State between January 1, 2010, and December 31, 2012. EXPOSURES Percutaneous coronary interventions, with complete and incomplete revascularization. MAIN OUTCOMES AND MEASURES Medium-term mortality. RESULTS For patients with STEMI, the mean age was 62.8 years; 26.2%were women, 11.9% were Hispanic, and 81.5%were white. For other patients, the mean age was 66.6 years, 29.1%were women, 11.3%were Hispanic, and 79.1%were white. Incomplete revascularization was very common (78%among patients with STEMI and 71%among other patients). Patients with IR in a vessel with at least 90% stenosis were at higher risk than other patients with IR. This was not significant among patients with STEMI (17.18%vs 12.86%; adjusted hazard ratio [AHR], 1.16; 95%CI, 0.99-1.37) and significant among patients without STEMI (17.71% vs 12.96%; AHR, 1.15; 95%CI, 1.07-1.24). Similarly, patients with IR in 2 or more vessels had higher mortality than patients with completely revascularization and higher mortality than other patients with IR among patients with STEMI (20.37%vs 14.39%; AHR, 1.35; 95%CI, 1.15-1.59) and among patients without STEMI (20.10% vs 12.86%; AHR, 1.17; 95% CI, 1.09-1.59). Patients with proximal left anterior descending artery vessel IR had higher mortality than other patients with IR (20.09% vs 14.67%; AHR, 1.31; 95%CI, 1.04-1.64 for patients with STEMI and 20.78%vs 15.62%; AHR, 1.11; 95%CI, 1.01-1.23 for patients without STEMI). More than 20%of all PCI patients had IR of 2 or more vessels and more than 30% had IR with more than 90% stenosis. CONCLUSIONS AND RELEVANCE Patients with IR are at higher risk of mortality if they have IR with at least 90% stenosis, IR in 2 or more vessels, or proximal left anterior descending IR.

Original languageEnglish (US)
Pages (from-to)123-130
Number of pages8
JournalJAMA Cardiology
Volume3
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Percutaneous Coronary Intervention
Coronary Vessels
Infarction
Mortality
Pathologic Constriction
Hispanic Americans
Arteries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Association of coronary vessel characteristics with outcome in patients with percutaneous coronary interventions with incomplete revascularization. / Hannan, Edward L.; Zhong, Ye; Berger, Peter B.; Jacobs, Alice K.; Walford, Gary D; Ling, Frederick S.K.; Venditti, Ferdinand J.; King, Spencer B.

In: JAMA Cardiology, Vol. 3, No. 2, 01.02.2018, p. 123-130.

Research output: Contribution to journalArticle

Hannan, Edward L. ; Zhong, Ye ; Berger, Peter B. ; Jacobs, Alice K. ; Walford, Gary D ; Ling, Frederick S.K. ; Venditti, Ferdinand J. ; King, Spencer B. / Association of coronary vessel characteristics with outcome in patients with percutaneous coronary interventions with incomplete revascularization. In: JAMA Cardiology. 2018 ; Vol. 3, No. 2. pp. 123-130.
@article{8e88828b5ec64ac38cf520414a0b4d5e,
title = "Association of coronary vessel characteristics with outcome in patients with percutaneous coronary interventions with incomplete revascularization",
abstract = "IMPORTANCE Many studies have compared outcomes for incomplete revascularization (IR) among patients undergoing percutaneous coronary interventions (PCI), but little is known about whether outcomes are related to the nature of the IR. OBJECTIVE To determine whether some coronary vessel characteristics are associated with worse outcomes in patients with PCI with IR. DESIGN, SETTING, AND PARTICIPANTS New York's PCI registrywas used to examine mortality (median follow-up, 3.4 years) as a function of the number of vessels that were incompletely revascularized, the stenosis in those vessels, and whether the proximal left anterior descending artery was incompletely revascularized after controlling for other factors associated with mortality for patients with and without ST-elevationmyocardial infarction (STEMI). This was a multicenter study (all nonfederal PCI hospitals in New York State) that included 41 639 New York residents with multivessel coronary artery disease undergoing PCI in New York State between January 1, 2010, and December 31, 2012. EXPOSURES Percutaneous coronary interventions, with complete and incomplete revascularization. MAIN OUTCOMES AND MEASURES Medium-term mortality. RESULTS For patients with STEMI, the mean age was 62.8 years; 26.2{\%}were women, 11.9{\%} were Hispanic, and 81.5{\%}were white. For other patients, the mean age was 66.6 years, 29.1{\%}were women, 11.3{\%}were Hispanic, and 79.1{\%}were white. Incomplete revascularization was very common (78{\%}among patients with STEMI and 71{\%}among other patients). Patients with IR in a vessel with at least 90{\%} stenosis were at higher risk than other patients with IR. This was not significant among patients with STEMI (17.18{\%}vs 12.86{\%}; adjusted hazard ratio [AHR], 1.16; 95{\%}CI, 0.99-1.37) and significant among patients without STEMI (17.71{\%} vs 12.96{\%}; AHR, 1.15; 95{\%}CI, 1.07-1.24). Similarly, patients with IR in 2 or more vessels had higher mortality than patients with completely revascularization and higher mortality than other patients with IR among patients with STEMI (20.37{\%}vs 14.39{\%}; AHR, 1.35; 95{\%}CI, 1.15-1.59) and among patients without STEMI (20.10{\%} vs 12.86{\%}; AHR, 1.17; 95{\%} CI, 1.09-1.59). Patients with proximal left anterior descending artery vessel IR had higher mortality than other patients with IR (20.09{\%} vs 14.67{\%}; AHR, 1.31; 95{\%}CI, 1.04-1.64 for patients with STEMI and 20.78{\%}vs 15.62{\%}; AHR, 1.11; 95{\%}CI, 1.01-1.23 for patients without STEMI). More than 20{\%}of all PCI patients had IR of 2 or more vessels and more than 30{\%} had IR with more than 90{\%} stenosis. CONCLUSIONS AND RELEVANCE Patients with IR are at higher risk of mortality if they have IR with at least 90{\%} stenosis, IR in 2 or more vessels, or proximal left anterior descending IR.",
author = "Hannan, {Edward L.} and Ye Zhong and Berger, {Peter B.} and Jacobs, {Alice K.} and Walford, {Gary D} and Ling, {Frederick S.K.} and Venditti, {Ferdinand J.} and King, {Spencer B.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1001/jamacardio.2017.4787",
language = "English (US)",
volume = "3",
pages = "123--130",
journal = "JAMA Cardiology",
issn = "2380-6583",
publisher = "American Medical Association",
number = "2",

}

TY - JOUR

T1 - Association of coronary vessel characteristics with outcome in patients with percutaneous coronary interventions with incomplete revascularization

AU - Hannan, Edward L.

AU - Zhong, Ye

AU - Berger, Peter B.

AU - Jacobs, Alice K.

AU - Walford, Gary D

AU - Ling, Frederick S.K.

AU - Venditti, Ferdinand J.

AU - King, Spencer B.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - IMPORTANCE Many studies have compared outcomes for incomplete revascularization (IR) among patients undergoing percutaneous coronary interventions (PCI), but little is known about whether outcomes are related to the nature of the IR. OBJECTIVE To determine whether some coronary vessel characteristics are associated with worse outcomes in patients with PCI with IR. DESIGN, SETTING, AND PARTICIPANTS New York's PCI registrywas used to examine mortality (median follow-up, 3.4 years) as a function of the number of vessels that were incompletely revascularized, the stenosis in those vessels, and whether the proximal left anterior descending artery was incompletely revascularized after controlling for other factors associated with mortality for patients with and without ST-elevationmyocardial infarction (STEMI). This was a multicenter study (all nonfederal PCI hospitals in New York State) that included 41 639 New York residents with multivessel coronary artery disease undergoing PCI in New York State between January 1, 2010, and December 31, 2012. EXPOSURES Percutaneous coronary interventions, with complete and incomplete revascularization. MAIN OUTCOMES AND MEASURES Medium-term mortality. RESULTS For patients with STEMI, the mean age was 62.8 years; 26.2%were women, 11.9% were Hispanic, and 81.5%were white. For other patients, the mean age was 66.6 years, 29.1%were women, 11.3%were Hispanic, and 79.1%were white. Incomplete revascularization was very common (78%among patients with STEMI and 71%among other patients). Patients with IR in a vessel with at least 90% stenosis were at higher risk than other patients with IR. This was not significant among patients with STEMI (17.18%vs 12.86%; adjusted hazard ratio [AHR], 1.16; 95%CI, 0.99-1.37) and significant among patients without STEMI (17.71% vs 12.96%; AHR, 1.15; 95%CI, 1.07-1.24). Similarly, patients with IR in 2 or more vessels had higher mortality than patients with completely revascularization and higher mortality than other patients with IR among patients with STEMI (20.37%vs 14.39%; AHR, 1.35; 95%CI, 1.15-1.59) and among patients without STEMI (20.10% vs 12.86%; AHR, 1.17; 95% CI, 1.09-1.59). Patients with proximal left anterior descending artery vessel IR had higher mortality than other patients with IR (20.09% vs 14.67%; AHR, 1.31; 95%CI, 1.04-1.64 for patients with STEMI and 20.78%vs 15.62%; AHR, 1.11; 95%CI, 1.01-1.23 for patients without STEMI). More than 20%of all PCI patients had IR of 2 or more vessels and more than 30% had IR with more than 90% stenosis. CONCLUSIONS AND RELEVANCE Patients with IR are at higher risk of mortality if they have IR with at least 90% stenosis, IR in 2 or more vessels, or proximal left anterior descending IR.

AB - IMPORTANCE Many studies have compared outcomes for incomplete revascularization (IR) among patients undergoing percutaneous coronary interventions (PCI), but little is known about whether outcomes are related to the nature of the IR. OBJECTIVE To determine whether some coronary vessel characteristics are associated with worse outcomes in patients with PCI with IR. DESIGN, SETTING, AND PARTICIPANTS New York's PCI registrywas used to examine mortality (median follow-up, 3.4 years) as a function of the number of vessels that were incompletely revascularized, the stenosis in those vessels, and whether the proximal left anterior descending artery was incompletely revascularized after controlling for other factors associated with mortality for patients with and without ST-elevationmyocardial infarction (STEMI). This was a multicenter study (all nonfederal PCI hospitals in New York State) that included 41 639 New York residents with multivessel coronary artery disease undergoing PCI in New York State between January 1, 2010, and December 31, 2012. EXPOSURES Percutaneous coronary interventions, with complete and incomplete revascularization. MAIN OUTCOMES AND MEASURES Medium-term mortality. RESULTS For patients with STEMI, the mean age was 62.8 years; 26.2%were women, 11.9% were Hispanic, and 81.5%were white. For other patients, the mean age was 66.6 years, 29.1%were women, 11.3%were Hispanic, and 79.1%were white. Incomplete revascularization was very common (78%among patients with STEMI and 71%among other patients). Patients with IR in a vessel with at least 90% stenosis were at higher risk than other patients with IR. This was not significant among patients with STEMI (17.18%vs 12.86%; adjusted hazard ratio [AHR], 1.16; 95%CI, 0.99-1.37) and significant among patients without STEMI (17.71% vs 12.96%; AHR, 1.15; 95%CI, 1.07-1.24). Similarly, patients with IR in 2 or more vessels had higher mortality than patients with completely revascularization and higher mortality than other patients with IR among patients with STEMI (20.37%vs 14.39%; AHR, 1.35; 95%CI, 1.15-1.59) and among patients without STEMI (20.10% vs 12.86%; AHR, 1.17; 95% CI, 1.09-1.59). Patients with proximal left anterior descending artery vessel IR had higher mortality than other patients with IR (20.09% vs 14.67%; AHR, 1.31; 95%CI, 1.04-1.64 for patients with STEMI and 20.78%vs 15.62%; AHR, 1.11; 95%CI, 1.01-1.23 for patients without STEMI). More than 20%of all PCI patients had IR of 2 or more vessels and more than 30% had IR with more than 90% stenosis. CONCLUSIONS AND RELEVANCE Patients with IR are at higher risk of mortality if they have IR with at least 90% stenosis, IR in 2 or more vessels, or proximal left anterior descending IR.

UR - http://www.scopus.com/inward/record.url?scp=85043501563&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043501563&partnerID=8YFLogxK

U2 - 10.1001/jamacardio.2017.4787

DO - 10.1001/jamacardio.2017.4787

M3 - Article

C2 - 29282471

AN - SCOPUS:85043501563

VL - 3

SP - 123

EP - 130

JO - JAMA Cardiology

JF - JAMA Cardiology

SN - 2380-6583

IS - 2

ER -