Association of combinations of polymorphisms in fibroblast growth factor receptor 2 gene with breast cancer among various ethnic groups

N. A. Aitkhozhina, A. K. Khanseitova, V. G. Nigmatova, A. S. Neupokoeva, D. A. Sharafutdinova, E. E. Ashirbekov, Alexander Favorov, T. S. Balmukhanov

Research output: Contribution to journalArticle

Abstract

A search for association of polymorphisms in loci rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 in fibroblast growth factor receptor 2 (FGFR2) gene was performed using the “case-control” method among the major ethnic groups of Kazakhstan. Restriction fragments length polymorphism analysis of DNA obtained from 495 Kazakh and 195 Russian women with breast cancer (BC) revealed no statistically significant differences compared with the control group (190 Kazakhs, 170 Russians). An assessment of combination associations of alleles and genotypes (patterns) with BC was performed using the APSampler algorithm. Association of risk type (OR > 1.4; PFischer < 0.05; Ppermutation < 0.05) in the Kazakh group identified two patterns, including allele C at site rs2420946, while the T allele was present in four protective patterns (OR < 0.70). No significant association of the examined polymorphisms with BC risk in the Russian group was revealed.

Original languageEnglish (US)
Pages (from-to)1042-1047
Number of pages6
JournalRussian Journal of Genetics
Volume53
Issue number9
DOIs
StatePublished - Sep 1 2017

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Receptor, Fibroblast Growth Factor, Type 2
Ethnic Groups
Alleles
Breast Neoplasms
Kazakhstan
Genes
Restriction Fragment Length Polymorphisms
Genotype
Control Groups
DNA

Keywords

  • APSampler
  • breast cancer
  • FGFR2 gene
  • Kazakhstan
  • polymorphism

ASJC Scopus subject areas

  • Genetics

Cite this

Aitkhozhina, N. A., Khanseitova, A. K., Nigmatova, V. G., Neupokoeva, A. S., Sharafutdinova, D. A., Ashirbekov, E. E., ... Balmukhanov, T. S. (2017). Association of combinations of polymorphisms in fibroblast growth factor receptor 2 gene with breast cancer among various ethnic groups. Russian Journal of Genetics, 53(9), 1042-1047. https://doi.org/10.1134/S1022795417090022

Association of combinations of polymorphisms in fibroblast growth factor receptor 2 gene with breast cancer among various ethnic groups. / Aitkhozhina, N. A.; Khanseitova, A. K.; Nigmatova, V. G.; Neupokoeva, A. S.; Sharafutdinova, D. A.; Ashirbekov, E. E.; Favorov, Alexander; Balmukhanov, T. S.

In: Russian Journal of Genetics, Vol. 53, No. 9, 01.09.2017, p. 1042-1047.

Research output: Contribution to journalArticle

Aitkhozhina, NA, Khanseitova, AK, Nigmatova, VG, Neupokoeva, AS, Sharafutdinova, DA, Ashirbekov, EE, Favorov, A & Balmukhanov, TS 2017, 'Association of combinations of polymorphisms in fibroblast growth factor receptor 2 gene with breast cancer among various ethnic groups', Russian Journal of Genetics, vol. 53, no. 9, pp. 1042-1047. https://doi.org/10.1134/S1022795417090022
Aitkhozhina, N. A. ; Khanseitova, A. K. ; Nigmatova, V. G. ; Neupokoeva, A. S. ; Sharafutdinova, D. A. ; Ashirbekov, E. E. ; Favorov, Alexander ; Balmukhanov, T. S. / Association of combinations of polymorphisms in fibroblast growth factor receptor 2 gene with breast cancer among various ethnic groups. In: Russian Journal of Genetics. 2017 ; Vol. 53, No. 9. pp. 1042-1047.
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