Association of combinations of polymorphisms in fibroblast growth factor receptor 2 gene with breast cancer among various ethnic groups

N. A. Aitkhozhina; A. K. Khanseitova; V. G. Nigmatova; A. S. Neupokoeva; D. A. Sharafutdinova; E. E. Ashirbekov; A. V. Favorov; T. S. Balmukhanov

doi:10.1134/S1022795417090022

Association of combinations of polymorphisms in fibroblast growth factor receptor 2 gene with breast cancer among various ethnic groups

N. A. Aitkhozhina, A. K. Khanseitova, V. G. Nigmatova, A. S. Neupokoeva, D. A. Sharafutdinova, E. E. Ashirbekov, A. V. Favorov, T. S. Balmukhanov

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

A search for association of polymorphisms in loci rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 in fibroblast growth factor receptor 2 (FGFR2) gene was performed using the “case-control” method among the major ethnic groups of Kazakhstan. Restriction fragments length polymorphism analysis of DNA obtained from 495 Kazakh and 195 Russian women with breast cancer (BC) revealed no statistically significant differences compared with the control group (190 Kazakhs, 170 Russians). An assessment of combination associations of alleles and genotypes (patterns) with BC was performed using the APSampler algorithm. Association of risk type (OR > 1.4; P_Fischer < 0.05; P_permutation < 0.05) in the Kazakh group identified two patterns, including allele C at site rs2420946, while the T allele was present in four protective patterns (OR < 0.70). No significant association of the examined polymorphisms with BC risk in the Russian group was revealed.

Original language	English (US)
Pages (from-to)	1042-1047
Number of pages	6
Journal	Russian Journal of Genetics
Volume	53
Issue number	9
DOIs	https://doi.org/10.1134/S1022795417090022
State	Published - Sep 1 2017

Keywords

APSampler
FGFR2 gene
Kazakhstan
breast cancer
polymorphism

ASJC Scopus subject areas

Genetics

Access to Document

10.1134/S1022795417090022

Cite this

Aitkhozhina, N. A., Khanseitova, A. K., Nigmatova, V. G., Neupokoeva, A. S., Sharafutdinova, D. A., Ashirbekov, E. E., Favorov, A. V., & Balmukhanov, T. S. (2017). Association of combinations of polymorphisms in fibroblast growth factor receptor 2 gene with breast cancer among various ethnic groups. Russian Journal of Genetics, 53(9), 1042-1047. https://doi.org/10.1134/S1022795417090022

Aitkhozhina, NA, Khanseitova, AK, Nigmatova, VG, Neupokoeva, AS, Sharafutdinova, DA, Ashirbekov, EE, Favorov, AV & Balmukhanov, TS 2017, 'Association of combinations of polymorphisms in fibroblast growth factor receptor 2 gene with breast cancer among various ethnic groups', Russian Journal of Genetics, vol. 53, no. 9, pp. 1042-1047. https://doi.org/10.1134/S1022795417090022

@article{2a4b832fa3c446da85c3475d1829b947,

title = "Association of combinations of polymorphisms in fibroblast growth factor receptor 2 gene with breast cancer among various ethnic groups",

abstract = "A search for association of polymorphisms in loci rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 in fibroblast growth factor receptor 2 (FGFR2) gene was performed using the “case-control” method among the major ethnic groups of Kazakhstan. Restriction fragments length polymorphism analysis of DNA obtained from 495 Kazakh and 195 Russian women with breast cancer (BC) revealed no statistically significant differences compared with the control group (190 Kazakhs, 170 Russians). An assessment of combination associations of alleles and genotypes (patterns) with BC was performed using the APSampler algorithm. Association of risk type (OR > 1.4; PFischer < 0.05; Ppermutation < 0.05) in the Kazakh group identified two patterns, including allele C at site rs2420946, while the T allele was present in four protective patterns (OR < 0.70). No significant association of the examined polymorphisms with BC risk in the Russian group was revealed.",

keywords = "APSampler, FGFR2 gene, Kazakhstan, breast cancer, polymorphism",

author = "Aitkhozhina, {N. A.} and Khanseitova, {A. K.} and Nigmatova, {V. G.} and Neupokoeva, {A. S.} and Sharafutdinova, {D. A.} and Ashirbekov, {E. E.} and Favorov, {A. V.} and Balmukhanov, {T. S.}",

note = "Funding Information: This study was supported by Research and Industrial Program of the Kazakh Ministry of Education and Science (project no. O.0633). Publisher Copyright: {\textcopyright} 2017, Pleiades Publishing, Inc.",

year = "2017",

month = sep,

day = "1",

doi = "10.1134/S1022795417090022",

language = "English (US)",

volume = "53",

pages = "1042--1047",

journal = "Russian Journal of Genetics",

issn = "1022-7954",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "9",

}

TY - JOUR

T1 - Association of combinations of polymorphisms in fibroblast growth factor receptor 2 gene with breast cancer among various ethnic groups

AU - Aitkhozhina, N. A.

AU - Khanseitova, A. K.

AU - Nigmatova, V. G.

AU - Neupokoeva, A. S.

AU - Sharafutdinova, D. A.

AU - Ashirbekov, E. E.

AU - Favorov, A. V.

AU - Balmukhanov, T. S.

N1 - Funding Information: This study was supported by Research and Industrial Program of the Kazakh Ministry of Education and Science (project no. O.0633). Publisher Copyright: © 2017, Pleiades Publishing, Inc.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - A search for association of polymorphisms in loci rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 in fibroblast growth factor receptor 2 (FGFR2) gene was performed using the “case-control” method among the major ethnic groups of Kazakhstan. Restriction fragments length polymorphism analysis of DNA obtained from 495 Kazakh and 195 Russian women with breast cancer (BC) revealed no statistically significant differences compared with the control group (190 Kazakhs, 170 Russians). An assessment of combination associations of alleles and genotypes (patterns) with BC was performed using the APSampler algorithm. Association of risk type (OR > 1.4; PFischer < 0.05; Ppermutation < 0.05) in the Kazakh group identified two patterns, including allele C at site rs2420946, while the T allele was present in four protective patterns (OR < 0.70). No significant association of the examined polymorphisms with BC risk in the Russian group was revealed.

AB - A search for association of polymorphisms in loci rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 in fibroblast growth factor receptor 2 (FGFR2) gene was performed using the “case-control” method among the major ethnic groups of Kazakhstan. Restriction fragments length polymorphism analysis of DNA obtained from 495 Kazakh and 195 Russian women with breast cancer (BC) revealed no statistically significant differences compared with the control group (190 Kazakhs, 170 Russians). An assessment of combination associations of alleles and genotypes (patterns) with BC was performed using the APSampler algorithm. Association of risk type (OR > 1.4; PFischer < 0.05; Ppermutation < 0.05) in the Kazakh group identified two patterns, including allele C at site rs2420946, while the T allele was present in four protective patterns (OR < 0.70). No significant association of the examined polymorphisms with BC risk in the Russian group was revealed.

KW - APSampler

KW - FGFR2 gene

KW - Kazakhstan

KW - breast cancer

KW - polymorphism

UR - http://www.scopus.com/inward/record.url?scp=85029798457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029798457&partnerID=8YFLogxK

U2 - 10.1134/S1022795417090022

DO - 10.1134/S1022795417090022

M3 - Article

AN - SCOPUS:85029798457

SN - 1022-7954

VL - 53

SP - 1042

EP - 1047

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

IS - 9

ER -

Association of combinations of polymorphisms in fibroblast growth factor receptor 2 gene with breast cancer among various ethnic groups

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this