Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli

Rachel Nadif, Margaret Mintz, Anne Jedlicka, Jean Pierre Bertrand, Steven R. Kleeberger, Francine Kauffmann

Research output: Contribution to journalArticlepeer-review

Abstract

We tested the hypotheses that catalase activity is modified by CAT single nucleotide polymorphisms (SNPs) (-262;-844), and by their interactions with oxidant exposures (coal dusts, smoking), lymphotoxin alpha (LTA, Nco I) and tumor necrosis factor (TNF,-308) in 196 miners. Erythrocyte catalase, superoxide dismutase, and glutathione peroxidase activities were measured. The CAT-262 SNP was related to lower catalase activity (104, 87 and 72 k/g hemoglobin for CC, CT and TT, respectively, p ≤ 0001). Regardless of CAT SNPs, the LTA Nco I but not the TNF-308 SNP was associated with catalase activity (p = 0.04 and p = 0.8). CAT -262 T carriers were less frequent in highly exposed miners (OR = 0.39 [0.20-0.78],p = 0.007). In CAT-262 T carriers only, catalase activity decreased with high dust exposure (p = 0.01). Haplotype analyses (combined CAT SNPs) confirm these results. Results show that CAT-262 and LTA Nco I SNPs, and interaction with coal dust exposure, influenced catalase activity.

Original languageEnglish (US)
Pages (from-to)1345-1350
Number of pages6
JournalFree Radical Research
Volume39
Issue number12
DOIs
StatePublished - Dec 2005

Keywords

  • Catalase
  • Catalase by environment interaction
  • Coal dust
  • Lymphotoxin
  • Polymorphism
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Biochemistry

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