Association of brachial–ankle pulse wave velocity and carotid plaque in Chinese hypertensive adults: effect modification by age

Zhihao Liu, Ying Yang, Yan Zhang, Liling Xie, Qinqin Li, Yun Song, Lishun Liu, Chengzhang Liu, Benjamin Xu, Binyan Wang, Tieci Yi, Fangfang Fan, Wei Ma, Haoyu Weng, Nan Zhang, Xiping Xu, Xiaobin Wang, Xianhui Qin, Yong Huo, Jianping Li

Research output: Contribution to journalArticle

Abstract

We aimed to investigate the association of brachial–ankle pulse wave velocity (baPWV) with carotid plaque presence and carotid plaque number in a Chinese hypertensive population. A total of 13,554 hypertensive subjects from the China Stroke Primary Prevention Trial (CSPPT) were recruited. Arterial stiffness and carotid plaque were evaluated by baPWV and B-mode ultrasonography, respectively. Multivariate logistic regression analysis was used to determine the correlation of baPWV and carotid plaque presence. Multinomial logistic regression analysis was used to determine the correlation of baPWV and carotid plaque number. Further interactions between baPWV and carotid plaque presence were examined using subgroup analysis. Continuous baPWV was positively correlated with carotid plaque presence (OR = 1.05, 95% CI: 1.04–1.07) and carotid plaque number (one- to two-plaque group: OR = 1.04, 95% CI: 1.02–1.06; three-or-more-plaque group: OR = 1.09, 95% CI: 1.07–1.12). When baPWV was classified into quartiles, with the lowest quartile as reference, the ORs for having one, two, or three or more plaques increased in parallel with the quartiles of baPWV, indicating a dose-dependent effect. In a subgroup analysis, the association of baPWV and carotid plaque presence was more pronounced among younger participants (OR: 1.14 vs. 1.06 and 1.03 for the age groups <60 years, 60 ≤ 70 years, and ≥70 years, respectively, P for interaction <0.001). In a Chinese hypertensive population, baPWV was positively associated with carotid plaque presence and carotid plaque number. A more pronounced positive association between baPWV and carotid plaque presence was observed in younger participants.

Original languageEnglish (US)
Pages (from-to)808-816
Number of pages9
JournalHypertension Research
Volume43
Issue number8
DOIs
StatePublished - Aug 1 2020

Keywords

  • Age
  • Brachial–ankle pulse wave velocity
  • Carotid plaque number
  • Carotid plaque presence
  • Hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Liu, Z., Yang, Y., Zhang, Y., Xie, L., Li, Q., Song, Y., Liu, L., Liu, C., Xu, B., Wang, B., Yi, T., Fan, F., Ma, W., Weng, H., Zhang, N., Xu, X., Wang, X., Qin, X., Huo, Y., & Li, J. (2020). Association of brachial–ankle pulse wave velocity and carotid plaque in Chinese hypertensive adults: effect modification by age. Hypertension Research, 43(8), 808-816. https://doi.org/10.1038/s41440-020-0432-2