TY - JOUR
T1 - Association of brachial–ankle pulse wave velocity and carotid plaque in Chinese hypertensive adults
T2 - effect modification by age
AU - Liu, Zhihao
AU - Yang, Ying
AU - Zhang, Yan
AU - Xie, Liling
AU - Li, Qinqin
AU - Song, Yun
AU - Liu, Lishun
AU - Liu, Chengzhang
AU - Xu, Benjamin
AU - Wang, Binyan
AU - Yi, Tieci
AU - Fan, Fangfang
AU - Ma, Wei
AU - Weng, Haoyu
AU - Zhang, Nan
AU - Xu, Xiping
AU - Wang, Xiaobin
AU - Qin, Xianhui
AU - Huo, Yong
AU - Li, Jianping
N1 - Funding Information:
Conflict of interest XX reports grants from the National Key Research and Development Program [2016YFE0205400, 2018ZX09739, 2018ZX09301034003]. XQ reports grants from the National Natural Science Foundation of China [81730019, 81973133] and Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University [2017J009]. No other disclosures were reported.
Funding Information:
Funding This work was supported by funding from the following: the National Key Research and Development Program (2016YFE0205400, 2018ZX09739, 2018ZX09301034003); the Projects of the National Natural Science Foundation of China (81730019, 81973133); the Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University (2017J009).
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/8/1
Y1 - 2020/8/1
N2 - We aimed to investigate the association of brachial–ankle pulse wave velocity (baPWV) with carotid plaque presence and carotid plaque number in a Chinese hypertensive population. A total of 13,554 hypertensive subjects from the China Stroke Primary Prevention Trial (CSPPT) were recruited. Arterial stiffness and carotid plaque were evaluated by baPWV and B-mode ultrasonography, respectively. Multivariate logistic regression analysis was used to determine the correlation of baPWV and carotid plaque presence. Multinomial logistic regression analysis was used to determine the correlation of baPWV and carotid plaque number. Further interactions between baPWV and carotid plaque presence were examined using subgroup analysis. Continuous baPWV was positively correlated with carotid plaque presence (OR = 1.05, 95% CI: 1.04–1.07) and carotid plaque number (one- to two-plaque group: OR = 1.04, 95% CI: 1.02–1.06; three-or-more-plaque group: OR = 1.09, 95% CI: 1.07–1.12). When baPWV was classified into quartiles, with the lowest quartile as reference, the ORs for having one, two, or three or more plaques increased in parallel with the quartiles of baPWV, indicating a dose-dependent effect. In a subgroup analysis, the association of baPWV and carotid plaque presence was more pronounced among younger participants (OR: 1.14 vs. 1.06 and 1.03 for the age groups <60 years, 60 ≤ 70 years, and ≥70 years, respectively, P for interaction <0.001). In a Chinese hypertensive population, baPWV was positively associated with carotid plaque presence and carotid plaque number. A more pronounced positive association between baPWV and carotid plaque presence was observed in younger participants.
AB - We aimed to investigate the association of brachial–ankle pulse wave velocity (baPWV) with carotid plaque presence and carotid plaque number in a Chinese hypertensive population. A total of 13,554 hypertensive subjects from the China Stroke Primary Prevention Trial (CSPPT) were recruited. Arterial stiffness and carotid plaque were evaluated by baPWV and B-mode ultrasonography, respectively. Multivariate logistic regression analysis was used to determine the correlation of baPWV and carotid plaque presence. Multinomial logistic regression analysis was used to determine the correlation of baPWV and carotid plaque number. Further interactions between baPWV and carotid plaque presence were examined using subgroup analysis. Continuous baPWV was positively correlated with carotid plaque presence (OR = 1.05, 95% CI: 1.04–1.07) and carotid plaque number (one- to two-plaque group: OR = 1.04, 95% CI: 1.02–1.06; three-or-more-plaque group: OR = 1.09, 95% CI: 1.07–1.12). When baPWV was classified into quartiles, with the lowest quartile as reference, the ORs for having one, two, or three or more plaques increased in parallel with the quartiles of baPWV, indicating a dose-dependent effect. In a subgroup analysis, the association of baPWV and carotid plaque presence was more pronounced among younger participants (OR: 1.14 vs. 1.06 and 1.03 for the age groups <60 years, 60 ≤ 70 years, and ≥70 years, respectively, P for interaction <0.001). In a Chinese hypertensive population, baPWV was positively associated with carotid plaque presence and carotid plaque number. A more pronounced positive association between baPWV and carotid plaque presence was observed in younger participants.
KW - Age
KW - Brachial–ankle pulse wave velocity
KW - Carotid plaque number
KW - Carotid plaque presence
KW - Hypertension
UR - http://www.scopus.com/inward/record.url?scp=85083591850&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083591850&partnerID=8YFLogxK
U2 - 10.1038/s41440-020-0432-2
DO - 10.1038/s41440-020-0432-2
M3 - Article
C2 - 32303686
AN - SCOPUS:85083591850
SN - 0916-9636
VL - 43
SP - 808
EP - 816
JO - Hypertension Research
JF - Hypertension Research
IS - 8
ER -