Association of Borderline Intellectual Functioning and Adverse Childhood Experience with adult psychiatric morbidity. Findings from a British birth cohort

Angela Hassiotis, Emma Brown, James Harris, David Helm, Kerim Munir, Luis Salvador-Carulla, Marco Bertelli, Amaria Baghdadli, Jannelien Wieland, Ramon Novell-Alsina, Jordi Cid, Laura Vergés, Rafael Martínez-Leal, Tuba Mutluer, Fuad Ismayilov, Eric Emerson

Research output: Contribution to journalArticle

Abstract

Background: To examine whether Borderline Intellectual Functioning (BIF) and Adverse Childhood Experiences independently predict adult psychiatric morbidity. Methods: We performed a secondary analysis of longitudinal data derived from the 1970 British Birth Cohort Study to examine whether BIF and Adverse Childhood Experiences independently predict adult mental distress as measured by the Malaise Inventory. Factor analysis was used to derive a proxy measure of IQ from cognitive testing at age 10 or 5. Variables that could be indicators of exposure to Adverse Childhood Experiences were identified and grouped into health related and socio-economic related adversity. Results: Children with BIF were significantly more likely than their peers to have been exposed to Adverse Childhood Experiences (BIF mean 5.90, non-BIF mean 3.19; Mann-Whitney z = 31.74, p < 0.001). As adults, participants with BIF were significantly more likely to score above the cut-off on the Malaise Inventory. We found statistically significant relationships between the number of socio-economic Adverse Childhood Experiences and poorer adult psychiatric morbidity (r range 0.104-0.141, all p < 001). At all ages the indirect mediating effects of Adverse Childhood Experiences were significantly related to adult psychiatric morbidity. Conclusions: The relationship between BIF and adult psychiatric morbidity appears to be partially mediated by exposure to Adverse Childhood Experiences. Where possible, targeting Adverse Childhood Experiences through early detection, prevention and interventions may improve psychiatric morbidity in this population group.

Original languageEnglish (US)
Article number387
JournalBMC psychiatry
Volume19
Issue number1
DOIs
StatePublished - Dec 5 2019

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Psychiatry
Parturition
Morbidity
Economics
Equipment and Supplies
Proxy
Population Groups
Statistical Factor Analysis
Cohort Studies
Health

Keywords

  • Adversity
  • Borderline
  • Childhood
  • Intellectual
  • Mental wellbeing

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Association of Borderline Intellectual Functioning and Adverse Childhood Experience with adult psychiatric morbidity. Findings from a British birth cohort. / Hassiotis, Angela; Brown, Emma; Harris, James; Helm, David; Munir, Kerim; Salvador-Carulla, Luis; Bertelli, Marco; Baghdadli, Amaria; Wieland, Jannelien; Novell-Alsina, Ramon; Cid, Jordi; Vergés, Laura; Martínez-Leal, Rafael; Mutluer, Tuba; Ismayilov, Fuad; Emerson, Eric.

In: BMC psychiatry, Vol. 19, No. 1, 387, 05.12.2019.

Research output: Contribution to journalArticle

Hassiotis, A, Brown, E, Harris, J, Helm, D, Munir, K, Salvador-Carulla, L, Bertelli, M, Baghdadli, A, Wieland, J, Novell-Alsina, R, Cid, J, Vergés, L, Martínez-Leal, R, Mutluer, T, Ismayilov, F & Emerson, E 2019, 'Association of Borderline Intellectual Functioning and Adverse Childhood Experience with adult psychiatric morbidity. Findings from a British birth cohort', BMC psychiatry, vol. 19, no. 1, 387. https://doi.org/10.1186/s12888-019-2376-0
Hassiotis, Angela ; Brown, Emma ; Harris, James ; Helm, David ; Munir, Kerim ; Salvador-Carulla, Luis ; Bertelli, Marco ; Baghdadli, Amaria ; Wieland, Jannelien ; Novell-Alsina, Ramon ; Cid, Jordi ; Vergés, Laura ; Martínez-Leal, Rafael ; Mutluer, Tuba ; Ismayilov, Fuad ; Emerson, Eric. / Association of Borderline Intellectual Functioning and Adverse Childhood Experience with adult psychiatric morbidity. Findings from a British birth cohort. In: BMC psychiatry. 2019 ; Vol. 19, No. 1.
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AU - Brown, Emma

AU - Harris, James

AU - Helm, David

AU - Munir, Kerim

AU - Salvador-Carulla, Luis

AU - Bertelli, Marco

AU - Baghdadli, Amaria

AU - Wieland, Jannelien

AU - Novell-Alsina, Ramon

AU - Cid, Jordi

AU - Vergés, Laura

AU - Martínez-Leal, Rafael

AU - Mutluer, Tuba

AU - Ismayilov, Fuad

AU - Emerson, Eric

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AB - Background: To examine whether Borderline Intellectual Functioning (BIF) and Adverse Childhood Experiences independently predict adult psychiatric morbidity. Methods: We performed a secondary analysis of longitudinal data derived from the 1970 British Birth Cohort Study to examine whether BIF and Adverse Childhood Experiences independently predict adult mental distress as measured by the Malaise Inventory. Factor analysis was used to derive a proxy measure of IQ from cognitive testing at age 10 or 5. Variables that could be indicators of exposure to Adverse Childhood Experiences were identified and grouped into health related and socio-economic related adversity. Results: Children with BIF were significantly more likely than their peers to have been exposed to Adverse Childhood Experiences (BIF mean 5.90, non-BIF mean 3.19; Mann-Whitney z = 31.74, p < 0.001). As adults, participants with BIF were significantly more likely to score above the cut-off on the Malaise Inventory. We found statistically significant relationships between the number of socio-economic Adverse Childhood Experiences and poorer adult psychiatric morbidity (r range 0.104-0.141, all p < 001). At all ages the indirect mediating effects of Adverse Childhood Experiences were significantly related to adult psychiatric morbidity. Conclusions: The relationship between BIF and adult psychiatric morbidity appears to be partially mediated by exposure to Adverse Childhood Experiences. Where possible, targeting Adverse Childhood Experiences through early detection, prevention and interventions may improve psychiatric morbidity in this population group.

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