Association of body composition and physical activity with proximal femur geometry in middle-aged and elderly afro-caribbean men: The tobago bone health study

Lisa Reider, T. J. Beck, J. A. Cauley, V. W. Wheeler, A. L. Patrick, C. H. Bunker, J. M. Zmuda

Research output: Contribution to journalArticle

Abstract

Osteoporotic fractures are less prevalent in African Americans than in caucasians, possibly because of differences in bone structural strength. Bone structural adaptation can be attributed to changes in load, crudely measured as lean and fat mass throughout life. The purpose of this analysis was to describe the associations of leg lean mass, total body fat mass, and hours walked per week with femoral bone mineral density (BMD) and bone geometry in a cross-sectional sample of 1,748 men of African descent between the ages of 40 and 79 years. BMD, section modulus (Z), cross-sectional area (CSA), and subperiosteal width were measured from dual energy X-ray absortiometry (DXA) scans using the hip structural analysis (HSA) program. Multiple linear regression models explained 35% to 48% of the variance in bending (Z) and axial (CSA) strength at the femoral neck and shaft. Independent of all covariates including total body fat mass, one standard deviation increase in leg lean mass was significantly associated with a 5% to 8% higher Z, CSA, and BMD (P <0.010) at the neck and shaft. The number of hours walked per week was not a strong or consistent independent predictor of bone geometry or BMD. We have shown that weight is the strongest independent predictor of femur BMD and geometric strength although the effect appears to be mediated by lean mass since leg lean mass fraction and total body fat mass fraction had significant and opposing effects at the narrow neck and shaft in this group of middle aged and elderly men.

Original languageEnglish (US)
Pages (from-to)160-166
Number of pages7
JournalCalcified Tissue International
Volume77
Issue number3
DOIs
StatePublished - Aug 2005

Fingerprint

Trinidad and Tobago
Body Composition
Bone Density
Femur
Exercise
Bone and Bones
Health
Adipose Tissue
Leg
Linear Models
Neck
Osteoporotic Fractures
Femur Neck
Thigh
African Americans
Hip
Fats
X-Rays
Weights and Measures

Keywords

  • African ancestry
  • Body composition
  • Femur geometry
  • Men
  • Osteoporosis

ASJC Scopus subject areas

  • Endocrinology

Cite this

Association of body composition and physical activity with proximal femur geometry in middle-aged and elderly afro-caribbean men : The tobago bone health study. / Reider, Lisa; Beck, T. J.; Cauley, J. A.; Wheeler, V. W.; Patrick, A. L.; Bunker, C. H.; Zmuda, J. M.

In: Calcified Tissue International, Vol. 77, No. 3, 08.2005, p. 160-166.

Research output: Contribution to journalArticle

Reider, Lisa ; Beck, T. J. ; Cauley, J. A. ; Wheeler, V. W. ; Patrick, A. L. ; Bunker, C. H. ; Zmuda, J. M. / Association of body composition and physical activity with proximal femur geometry in middle-aged and elderly afro-caribbean men : The tobago bone health study. In: Calcified Tissue International. 2005 ; Vol. 77, No. 3. pp. 160-166.
@article{7a02eb5463e74909b967629d4da0c0b0,
title = "Association of body composition and physical activity with proximal femur geometry in middle-aged and elderly afro-caribbean men: The tobago bone health study",
abstract = "Osteoporotic fractures are less prevalent in African Americans than in caucasians, possibly because of differences in bone structural strength. Bone structural adaptation can be attributed to changes in load, crudely measured as lean and fat mass throughout life. The purpose of this analysis was to describe the associations of leg lean mass, total body fat mass, and hours walked per week with femoral bone mineral density (BMD) and bone geometry in a cross-sectional sample of 1,748 men of African descent between the ages of 40 and 79 years. BMD, section modulus (Z), cross-sectional area (CSA), and subperiosteal width were measured from dual energy X-ray absortiometry (DXA) scans using the hip structural analysis (HSA) program. Multiple linear regression models explained 35{\%} to 48{\%} of the variance in bending (Z) and axial (CSA) strength at the femoral neck and shaft. Independent of all covariates including total body fat mass, one standard deviation increase in leg lean mass was significantly associated with a 5{\%} to 8{\%} higher Z, CSA, and BMD (P <0.010) at the neck and shaft. The number of hours walked per week was not a strong or consistent independent predictor of bone geometry or BMD. We have shown that weight is the strongest independent predictor of femur BMD and geometric strength although the effect appears to be mediated by lean mass since leg lean mass fraction and total body fat mass fraction had significant and opposing effects at the narrow neck and shaft in this group of middle aged and elderly men.",
keywords = "African ancestry, Body composition, Femur geometry, Men, Osteoporosis",
author = "Lisa Reider and Beck, {T. J.} and Cauley, {J. A.} and Wheeler, {V. W.} and Patrick, {A. L.} and Bunker, {C. H.} and Zmuda, {J. M.}",
year = "2005",
month = "8",
doi = "10.1007/s00223-005-0037-4",
language = "English (US)",
volume = "77",
pages = "160--166",
journal = "Calcified Tissue International",
issn = "0171-967X",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Association of body composition and physical activity with proximal femur geometry in middle-aged and elderly afro-caribbean men

T2 - The tobago bone health study

AU - Reider, Lisa

AU - Beck, T. J.

AU - Cauley, J. A.

AU - Wheeler, V. W.

AU - Patrick, A. L.

AU - Bunker, C. H.

AU - Zmuda, J. M.

PY - 2005/8

Y1 - 2005/8

N2 - Osteoporotic fractures are less prevalent in African Americans than in caucasians, possibly because of differences in bone structural strength. Bone structural adaptation can be attributed to changes in load, crudely measured as lean and fat mass throughout life. The purpose of this analysis was to describe the associations of leg lean mass, total body fat mass, and hours walked per week with femoral bone mineral density (BMD) and bone geometry in a cross-sectional sample of 1,748 men of African descent between the ages of 40 and 79 years. BMD, section modulus (Z), cross-sectional area (CSA), and subperiosteal width were measured from dual energy X-ray absortiometry (DXA) scans using the hip structural analysis (HSA) program. Multiple linear regression models explained 35% to 48% of the variance in bending (Z) and axial (CSA) strength at the femoral neck and shaft. Independent of all covariates including total body fat mass, one standard deviation increase in leg lean mass was significantly associated with a 5% to 8% higher Z, CSA, and BMD (P <0.010) at the neck and shaft. The number of hours walked per week was not a strong or consistent independent predictor of bone geometry or BMD. We have shown that weight is the strongest independent predictor of femur BMD and geometric strength although the effect appears to be mediated by lean mass since leg lean mass fraction and total body fat mass fraction had significant and opposing effects at the narrow neck and shaft in this group of middle aged and elderly men.

AB - Osteoporotic fractures are less prevalent in African Americans than in caucasians, possibly because of differences in bone structural strength. Bone structural adaptation can be attributed to changes in load, crudely measured as lean and fat mass throughout life. The purpose of this analysis was to describe the associations of leg lean mass, total body fat mass, and hours walked per week with femoral bone mineral density (BMD) and bone geometry in a cross-sectional sample of 1,748 men of African descent between the ages of 40 and 79 years. BMD, section modulus (Z), cross-sectional area (CSA), and subperiosteal width were measured from dual energy X-ray absortiometry (DXA) scans using the hip structural analysis (HSA) program. Multiple linear regression models explained 35% to 48% of the variance in bending (Z) and axial (CSA) strength at the femoral neck and shaft. Independent of all covariates including total body fat mass, one standard deviation increase in leg lean mass was significantly associated with a 5% to 8% higher Z, CSA, and BMD (P <0.010) at the neck and shaft. The number of hours walked per week was not a strong or consistent independent predictor of bone geometry or BMD. We have shown that weight is the strongest independent predictor of femur BMD and geometric strength although the effect appears to be mediated by lean mass since leg lean mass fraction and total body fat mass fraction had significant and opposing effects at the narrow neck and shaft in this group of middle aged and elderly men.

KW - African ancestry

KW - Body composition

KW - Femur geometry

KW - Men

KW - Osteoporosis

UR - http://www.scopus.com/inward/record.url?scp=27644582389&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27644582389&partnerID=8YFLogxK

U2 - 10.1007/s00223-005-0037-4

DO - 10.1007/s00223-005-0037-4

M3 - Article

C2 - 16151673

AN - SCOPUS:27644582389

VL - 77

SP - 160

EP - 166

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 0171-967X

IS - 3

ER -