TY - JOUR
T1 - Association of blood lactate with type 2 diabetes
T2 - The atherosclerosis risk in communities carotid MRI study
AU - Crawford, Stephen O.
AU - Hoogeveen, Ron C.
AU - Brancati, Frederick L.
AU - Astor, Brad C.
AU - Ballantyne, Christie M.
AU - Schmidt, Maria Inês
AU - Young, Jeffery Hunter
N1 - Funding Information:
National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases T32 training grant to S.C. J.H.Y. was supported by National Institutes of Health through a research career award, American Heart Association through a scientist development award, and the American Diabetes Association through an Innovation Award. The ARIC Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021 and N01-HC-55022.
PY - 2010/12
Y1 - 2010/12
N2 - Background: Accumulating evidence implicates insufficient oxidative capacity in the development of type 2 diabetes. This notion has not been well tested in large, population-based studies. Methods: To test this hypothesis, we assessed the cross-sectional association of plasma lactate, an indicator of the gap between oxidative capacity and energy expenditure, with type 2 diabetes in 1709 older adults not taking metformin, who were participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study. Results: The prevalence of type 2 diabetes rose across lactate quartiles (11, 14, 20 and 30%; P for trend <0.0001). Following adjustment for demographic factors, physical activity, body mass index and waist circumference, the relative odds of type 2 diabetes across lactate quartiles were 0.98 [95% confidence interval (CI) 0.59-1.64], 1.64 (95% CI 1.03-2.64) and 2.23 (95% CI 1.38-3.59), respectively. Furthermore, lactate was associated with higher fasting glucose among non-diabetic adults. Conclusions: Plasma lactate was strongly associated with type 2 diabetes in older adults. Plasma lactate deserves greater attention in studies of oxidative capacity and diabetes risk. Published by Oxford University Press on behalf of the International Epidemiological Association
AB - Background: Accumulating evidence implicates insufficient oxidative capacity in the development of type 2 diabetes. This notion has not been well tested in large, population-based studies. Methods: To test this hypothesis, we assessed the cross-sectional association of plasma lactate, an indicator of the gap between oxidative capacity and energy expenditure, with type 2 diabetes in 1709 older adults not taking metformin, who were participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study. Results: The prevalence of type 2 diabetes rose across lactate quartiles (11, 14, 20 and 30%; P for trend <0.0001). Following adjustment for demographic factors, physical activity, body mass index and waist circumference, the relative odds of type 2 diabetes across lactate quartiles were 0.98 [95% confidence interval (CI) 0.59-1.64], 1.64 (95% CI 1.03-2.64) and 2.23 (95% CI 1.38-3.59), respectively. Furthermore, lactate was associated with higher fasting glucose among non-diabetic adults. Conclusions: Plasma lactate was strongly associated with type 2 diabetes in older adults. Plasma lactate deserves greater attention in studies of oxidative capacity and diabetes risk. Published by Oxford University Press on behalf of the International Epidemiological Association
KW - Diabetes mellitus
KW - Epidemiology
KW - Glycolysis
KW - Insulin resistance
KW - Lactic acid
KW - Oxidative phosphorylation
KW - Type 2
UR - http://www.scopus.com/inward/record.url?scp=78649764303&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649764303&partnerID=8YFLogxK
U2 - 10.1093/ije/dyq126
DO - 10.1093/ije/dyq126
M3 - Article
C2 - 20797988
AN - SCOPUS:78649764303
SN - 0300-5771
VL - 39
SP - 1647
EP - 1655
JO - International journal of epidemiology
JF - International journal of epidemiology
IS - 6
M1 - dyq126
ER -