Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants

R. R. Arthur, K. V. Shah, S. J. Baust, G. W. Santos, R. Saral

Research output: Contribution to journalArticle

Abstract

Fifty-three recipients of bone marrow transplants were monitored prospectively for urinary excretion of human polyomaviruses by enzyme-linked immunosorbent assays of urinary supernatants and DNA hybridization assays of urinary cells. Excretion of BK virus was demonstrated in 47 percent of the transplant recipients and was the result of the reactivation of latent virus. Hemorrhagic cystitis of long duration (≥ 7 days) was associated with BK viruria. The disease occurred four times more frequently in patients who excreted BK virus than in those who did not, and the virus was identified in 55 percent of the urine specimens during episodes of cystitis as compared with 8 to 11 percent of the specimens during cystitis-free periods. BK viruria often preceeded or coincided with the onset of the disease. Among 19 patients with BK viruria lasting seven days or longer, hemorrhagic cystitis occurred in 15. Occurrence of the disease was related to the source of marrow. The disease occurred in 50 percent of 38 recipients of allogeneic marrow and in 7 percent of 15 recipients of syngeneic or autologous marrow. Among recipients of allogeneic marrow, the disease was observed in 71 percent of the 21 patients excreting BK virus and in 24 percent of the 17 not excreting the virus. An association of BK virus with hemorrhagic cystitis was demonstrated in 16 of the 18 cases of the disease that were adequately characterized. We conclude that reactivation of BK virus may account for a substantial proportion of late-onset, long-lasting hemorrhagic cystitis in recipients of bone marrow transplants.

Original languageEnglish (US)
Pages (from-to)230-234
Number of pages5
JournalNew England Journal of Medicine
Volume315
Issue number4
StatePublished - 1986

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Cystitis
BK Virus
Bone Marrow
Transplants
Viruses
Polyomavirus
Enzyme-Linked Immunosorbent Assay
Urine
DNA

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Arthur, R. R., Shah, K. V., Baust, S. J., Santos, G. W., & Saral, R. (1986). Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants. New England Journal of Medicine, 315(4), 230-234.

Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants. / Arthur, R. R.; Shah, K. V.; Baust, S. J.; Santos, G. W.; Saral, R.

In: New England Journal of Medicine, Vol. 315, No. 4, 1986, p. 230-234.

Research output: Contribution to journalArticle

Arthur, RR, Shah, KV, Baust, SJ, Santos, GW & Saral, R 1986, 'Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants', New England Journal of Medicine, vol. 315, no. 4, pp. 230-234.
Arthur, R. R. ; Shah, K. V. ; Baust, S. J. ; Santos, G. W. ; Saral, R. / Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants. In: New England Journal of Medicine. 1986 ; Vol. 315, No. 4. pp. 230-234.
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