Association of bisphenol a exposure with hypertension and early macrovascular diseases in Chinese adults: A cross-sectional study

Tiange Wang, Min Xu, Yu Xu, Jieli Lu, Mian Li, Yuhong Chen, Weiqing Wang, Shenghan Lai, Yufang Bi, Guang Ning

Research output: Contribution to journalArticle

Abstract

Bisphenol A (BPA) is an environmental endocrine disruptor that has been associated with cardiovascular outcomes in previous observational studies. We aimed to examine the relationships of urinary BPA levels with hypertension and early macrovascular diseases. This is a cross-sectional study. From June through August 2009, 3246 participants ages 40 years or older were enrolled from Baoshan District, Shanghai, China. Logistic regression modes were used to estimate the odds ratios (ORs) for prevalent risk of hypertension, elevated carotid intima-media thickness (CIMT), arterial stiffness, and peripheral artery disease (PAD) with multivariable adjustment. We also performed stratification analysis by age and sex. The median (interquartile range) for BPA was 0.81 (0.48, 1.45) ng/mL, which is notably lower than previously reported in the United States and other Western countries. Urinary BPA concentrations were negatively associated with hypertension (multivariable-adjusted OR for the highest versus lowest BPA quartile=0.61; 95% confidence interval [CI]: 0.46, 0.80), elevated CIMT (OR=0.64; 95% CI: 0.47, 0.87), and arterial stiffness (OR=0.62; 95% CI: 0.44, 0.87). The corresponding OR for PAD (60 cases total) was not significant (OR=0.89; 95% CI: 0.28, 2.80). The negative associations of BPA with hypertension, elevated CIMT, and arterial stiffness were consistent by age and sex stratifications, and were stronger among participants ≥60 versus

Original languageEnglish (US)
Article numbere1814
JournalMedicine (United States)
Volume94
Issue number43
DOIs
StatePublished - 2015

Fingerprint

Cross-Sectional Studies
Odds Ratio
Hypertension
Carotid Intima-Media Thickness
Vascular Stiffness
Confidence Intervals
Peripheral Arterial Disease
Endocrine Disruptors
Observational Studies
bisphenol A
China
Logistic Models

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Association of bisphenol a exposure with hypertension and early macrovascular diseases in Chinese adults : A cross-sectional study. / Wang, Tiange; Xu, Min; Xu, Yu; Lu, Jieli; Li, Mian; Chen, Yuhong; Wang, Weiqing; Lai, Shenghan; Bi, Yufang; Ning, Guang.

In: Medicine (United States), Vol. 94, No. 43, e1814, 2015.

Research output: Contribution to journalArticle

Wang, Tiange ; Xu, Min ; Xu, Yu ; Lu, Jieli ; Li, Mian ; Chen, Yuhong ; Wang, Weiqing ; Lai, Shenghan ; Bi, Yufang ; Ning, Guang. / Association of bisphenol a exposure with hypertension and early macrovascular diseases in Chinese adults : A cross-sectional study. In: Medicine (United States). 2015 ; Vol. 94, No. 43.
@article{5fb795b34df4416887084847c7e7d398,
title = "Association of bisphenol a exposure with hypertension and early macrovascular diseases in Chinese adults: A cross-sectional study",
abstract = "Bisphenol A (BPA) is an environmental endocrine disruptor that has been associated with cardiovascular outcomes in previous observational studies. We aimed to examine the relationships of urinary BPA levels with hypertension and early macrovascular diseases. This is a cross-sectional study. From June through August 2009, 3246 participants ages 40 years or older were enrolled from Baoshan District, Shanghai, China. Logistic regression modes were used to estimate the odds ratios (ORs) for prevalent risk of hypertension, elevated carotid intima-media thickness (CIMT), arterial stiffness, and peripheral artery disease (PAD) with multivariable adjustment. We also performed stratification analysis by age and sex. The median (interquartile range) for BPA was 0.81 (0.48, 1.45) ng/mL, which is notably lower than previously reported in the United States and other Western countries. Urinary BPA concentrations were negatively associated with hypertension (multivariable-adjusted OR for the highest versus lowest BPA quartile=0.61; 95{\%} confidence interval [CI]: 0.46, 0.80), elevated CIMT (OR=0.64; 95{\%} CI: 0.47, 0.87), and arterial stiffness (OR=0.62; 95{\%} CI: 0.44, 0.87). The corresponding OR for PAD (60 cases total) was not significant (OR=0.89; 95{\%} CI: 0.28, 2.80). The negative associations of BPA with hypertension, elevated CIMT, and arterial stiffness were consistent by age and sex stratifications, and were stronger among participants ≥60 versus",
author = "Tiange Wang and Min Xu and Yu Xu and Jieli Lu and Mian Li and Yuhong Chen and Weiqing Wang and Shenghan Lai and Yufang Bi and Guang Ning",
year = "2015",
doi = "10.1097/MD.0000000000001814",
language = "English (US)",
volume = "94",
journal = "Medicine",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "43",

}

TY - JOUR

T1 - Association of bisphenol a exposure with hypertension and early macrovascular diseases in Chinese adults

T2 - A cross-sectional study

AU - Wang, Tiange

AU - Xu, Min

AU - Xu, Yu

AU - Lu, Jieli

AU - Li, Mian

AU - Chen, Yuhong

AU - Wang, Weiqing

AU - Lai, Shenghan

AU - Bi, Yufang

AU - Ning, Guang

PY - 2015

Y1 - 2015

N2 - Bisphenol A (BPA) is an environmental endocrine disruptor that has been associated with cardiovascular outcomes in previous observational studies. We aimed to examine the relationships of urinary BPA levels with hypertension and early macrovascular diseases. This is a cross-sectional study. From June through August 2009, 3246 participants ages 40 years or older were enrolled from Baoshan District, Shanghai, China. Logistic regression modes were used to estimate the odds ratios (ORs) for prevalent risk of hypertension, elevated carotid intima-media thickness (CIMT), arterial stiffness, and peripheral artery disease (PAD) with multivariable adjustment. We also performed stratification analysis by age and sex. The median (interquartile range) for BPA was 0.81 (0.48, 1.45) ng/mL, which is notably lower than previously reported in the United States and other Western countries. Urinary BPA concentrations were negatively associated with hypertension (multivariable-adjusted OR for the highest versus lowest BPA quartile=0.61; 95% confidence interval [CI]: 0.46, 0.80), elevated CIMT (OR=0.64; 95% CI: 0.47, 0.87), and arterial stiffness (OR=0.62; 95% CI: 0.44, 0.87). The corresponding OR for PAD (60 cases total) was not significant (OR=0.89; 95% CI: 0.28, 2.80). The negative associations of BPA with hypertension, elevated CIMT, and arterial stiffness were consistent by age and sex stratifications, and were stronger among participants ≥60 versus

AB - Bisphenol A (BPA) is an environmental endocrine disruptor that has been associated with cardiovascular outcomes in previous observational studies. We aimed to examine the relationships of urinary BPA levels with hypertension and early macrovascular diseases. This is a cross-sectional study. From June through August 2009, 3246 participants ages 40 years or older were enrolled from Baoshan District, Shanghai, China. Logistic regression modes were used to estimate the odds ratios (ORs) for prevalent risk of hypertension, elevated carotid intima-media thickness (CIMT), arterial stiffness, and peripheral artery disease (PAD) with multivariable adjustment. We also performed stratification analysis by age and sex. The median (interquartile range) for BPA was 0.81 (0.48, 1.45) ng/mL, which is notably lower than previously reported in the United States and other Western countries. Urinary BPA concentrations were negatively associated with hypertension (multivariable-adjusted OR for the highest versus lowest BPA quartile=0.61; 95% confidence interval [CI]: 0.46, 0.80), elevated CIMT (OR=0.64; 95% CI: 0.47, 0.87), and arterial stiffness (OR=0.62; 95% CI: 0.44, 0.87). The corresponding OR for PAD (60 cases total) was not significant (OR=0.89; 95% CI: 0.28, 2.80). The negative associations of BPA with hypertension, elevated CIMT, and arterial stiffness were consistent by age and sex stratifications, and were stronger among participants ≥60 versus

UR - http://www.scopus.com/inward/record.url?scp=84946574590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946574590&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000001814

DO - 10.1097/MD.0000000000001814

M3 - Article

C2 - 26512580

AN - SCOPUS:84946574590

VL - 94

JO - Medicine

JF - Medicine

SN - 0025-7974

IS - 43

M1 - e1814

ER -