TY - JOUR
T1 - Association of baseline sex hormone levels with baseline and longitudinal changes in waist-to-hip ratio
T2 - Multi-Ethnic Study of Atherosclerosis
AU - Vaidya, D.
AU - Dobs, A.
AU - Gapstur, S. M.
AU - Golden, S. H.
AU - Cushman, M.
AU - Liu, K.
AU - Ouyang, P.
N1 - Funding Information:
We thank the other investigators, the staff and the participants of the MESA study for their valuable contributions. This research was supported by RO1 HL074406, RO1 HL-74338, UL1 RR 025005 and contracts N01-HC-95159 through N01-HC-95165 and N01-HC-95169 from the National Heart, Lung and Blood Institute. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi. org. DV was supported by the National Center for Research Resources (Grant No. UL1 RR 025005), a component of the National Institutes of Health.
PY - 2012/12
Y1 - 2012/12
N2 - OBJECTIVE:Waist-to-hip ratio (WHR) is strongly associated with prevalent atherosclerosis. We analyzed the associations of baseline serum levels of testosterone (T), estradiol (E2), sex-hormone-binding globulin (SHBG) and dehydroepiandrosterone (DHEA) with WHR in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.SUBJECTS:Baseline data was available for 3144 men and 2038 postmenopausal women, who were non-users of hormone therapy, who were 45-84 years of age, and of White, Chinese, Black or Hispanic racial/ethnic groups. Of these, 2708 men and 1678 women also had longitudinal measurements of WHR measured at the second and/or the third study visits (median follow-up 578 days and 1135 days, respectively).RESULTS:In cross-sectional analyses adjusted for age, race and cardiovascular disease risk factors, T was negatively associated with baseline WHR in men, whereas in both sexes, E2 was positively associated and SHBG was negatively associated with WHR (all P<0.001). In longitudinal analyses, further adjusted for follow-up time and baseline WHR, baseline T was negatively associated with WHR at follow-up (P=0.001) in men, whereas in both sexes, E2 was positively associated (P=0.004) and SHBG was negatively associated with WHR (P<0.001). The longitudinal association of E2, but not T, was independent of SHBG. In cross-sectional or longitudinal analyses, there were no associations between DHEA and WHR in either men or women.CONCLUSION:Sex hormones are associated with WHR at baseline and also during follow-up above and beyond their baseline association. Future research is needed to determine if manipulation of hormones is associated with changes in central obesity.
AB - OBJECTIVE:Waist-to-hip ratio (WHR) is strongly associated with prevalent atherosclerosis. We analyzed the associations of baseline serum levels of testosterone (T), estradiol (E2), sex-hormone-binding globulin (SHBG) and dehydroepiandrosterone (DHEA) with WHR in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.SUBJECTS:Baseline data was available for 3144 men and 2038 postmenopausal women, who were non-users of hormone therapy, who were 45-84 years of age, and of White, Chinese, Black or Hispanic racial/ethnic groups. Of these, 2708 men and 1678 women also had longitudinal measurements of WHR measured at the second and/or the third study visits (median follow-up 578 days and 1135 days, respectively).RESULTS:In cross-sectional analyses adjusted for age, race and cardiovascular disease risk factors, T was negatively associated with baseline WHR in men, whereas in both sexes, E2 was positively associated and SHBG was negatively associated with WHR (all P<0.001). In longitudinal analyses, further adjusted for follow-up time and baseline WHR, baseline T was negatively associated with WHR at follow-up (P=0.001) in men, whereas in both sexes, E2 was positively associated (P=0.004) and SHBG was negatively associated with WHR (P<0.001). The longitudinal association of E2, but not T, was independent of SHBG. In cross-sectional or longitudinal analyses, there were no associations between DHEA and WHR in either men or women.CONCLUSION:Sex hormones are associated with WHR at baseline and also during follow-up above and beyond their baseline association. Future research is needed to determine if manipulation of hormones is associated with changes in central obesity.
KW - epidemiology
KW - sex hormones
KW - waist-to-hip ratio
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U2 - 10.1038/ijo.2012.3
DO - 10.1038/ijo.2012.3
M3 - Article
C2 - 22270378
AN - SCOPUS:84871025974
SN - 0307-0565
VL - 36
SP - 1578
EP - 1584
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 12
ER -