TY - JOUR
T1 - Association of aortic stiffness with left ventricular remodeling and reduced left ventricular function measured by magnetic resonance imaging
T2 - The multi-ethnic study of atherosclerosis
AU - Ohyama, Yoshiaki
AU - Ambale-Venkatesh, Bharath
AU - Noda, Chikara
AU - Chugh, Atul R.
AU - Teixido-Tura, Gisela
AU - Kim, Jang Young
AU - Donekal, Sirisha
AU - Yoneyama, Kihei
AU - Gjesdal, Ola
AU - Redheuil, Alban
AU - Liu, Chia Ying
AU - Nakamura, Tetsuya
AU - Wu, Colin O.
AU - Hundley, W. Gregory
AU - Bluemke, David A.
AU - Lima, Joao A.C.
N1 - Funding Information:
This research was supported by contracts N01-HC-95159, N01- HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01- HC-95164, N01-HC-95165, N01-HC-95166, and N01-HC-95168 from the National Heart, Lung, and Blood Institute.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Background - This study sought to assess cross-sectional associations of aortic stiffness assessed by magnetic resonance imaging with left ventricular (LV) remodeling and myocardial deformation in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods and Results - Aortic arch pulse wave velocity (PWV) was measured with phase contrast cine magnetic resonance imaging. LV circumferential strain (Ecc), torsion, and early diastolic strain rate were determined by tagged magnetic resonance imaging. Multivariable linear regression models were used to adjust for demographics and cardiovascular risk factors. Of 2093 participants, multivariable linear regression models demonstrated that higher arch PWV was associated with higher LV mass index (B=0.53 per 1 SD increase for log-transformed PWV, P<0.05) and LV mass to volume ratio (B=0.015, P<0.01), impaired LV ejection fraction (LVEF; B=-0.84; P<0.001), Ecc (B=0.55; P<0.001), torsion (B=-0.11; P<0.001), and early diastolic strain rate (B=-0.003; P<0.05). In sex stratified analysis, higher arch PWV was associated with higher MVR (B=0.02; P<0.05), impaired Ecc (B=0.60; P<0.001), and LVEF (B=-0.45; P<0.05), but with maintained torsion in women. Higher PWV was associated with impaired Ecc (B=0.49; P<0.001) and LVEF (B=-1.21; P<0.001), with lower torsion (B=-0.17; P<0.001) in men. Conclusions - Higher arch PWV is associated with LV remodeling, and reduced LV systolic and diastolic function in a large multiethnic population. Greater aortic arch stiffness is associated with concentric LV remodeling and relatively preserved LVEF with maintained torsion in women, whereas greater aortic arch stiffness is associated with greater LV dysfunction demonstrated as impaired Ecc, torsion, and LVEF, with less concentric LV remodeling in men.
AB - Background - This study sought to assess cross-sectional associations of aortic stiffness assessed by magnetic resonance imaging with left ventricular (LV) remodeling and myocardial deformation in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods and Results - Aortic arch pulse wave velocity (PWV) was measured with phase contrast cine magnetic resonance imaging. LV circumferential strain (Ecc), torsion, and early diastolic strain rate were determined by tagged magnetic resonance imaging. Multivariable linear regression models were used to adjust for demographics and cardiovascular risk factors. Of 2093 participants, multivariable linear regression models demonstrated that higher arch PWV was associated with higher LV mass index (B=0.53 per 1 SD increase for log-transformed PWV, P<0.05) and LV mass to volume ratio (B=0.015, P<0.01), impaired LV ejection fraction (LVEF; B=-0.84; P<0.001), Ecc (B=0.55; P<0.001), torsion (B=-0.11; P<0.001), and early diastolic strain rate (B=-0.003; P<0.05). In sex stratified analysis, higher arch PWV was associated with higher MVR (B=0.02; P<0.05), impaired Ecc (B=0.60; P<0.001), and LVEF (B=-0.45; P<0.05), but with maintained torsion in women. Higher PWV was associated with impaired Ecc (B=0.49; P<0.001) and LVEF (B=-1.21; P<0.001), with lower torsion (B=-0.17; P<0.001) in men. Conclusions - Higher arch PWV is associated with LV remodeling, and reduced LV systolic and diastolic function in a large multiethnic population. Greater aortic arch stiffness is associated with concentric LV remodeling and relatively preserved LVEF with maintained torsion in women, whereas greater aortic arch stiffness is associated with greater LV dysfunction demonstrated as impaired Ecc, torsion, and LVEF, with less concentric LV remodeling in men.
KW - epidemiology
KW - heart ventricles
KW - magnetic resonance imaging
KW - pulse wave analysis
KW - vascular stiffness
UR - http://www.scopus.com/inward/record.url?scp=84978937985&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978937985&partnerID=8YFLogxK
U2 - 10.1161/CIRCIMAGING.115.004426
DO - 10.1161/CIRCIMAGING.115.004426
M3 - Article
C2 - 27353852
AN - SCOPUS:84978937985
SN - 1941-9651
VL - 9
JO - Circulation: Cardiovascular Imaging
JF - Circulation: Cardiovascular Imaging
IS - 7
ER -