Abstract
Background: Both aortic atherosclerosis (AA) and renal dysfunction are associated with increased morbidity and mortality. We sought to assess the association between AA and renal dysfunction. Methods: The study consisted of 200 consecutive patients (62% were male, mean age 69 ± 11 years) who underwent transesophageal echocardiography. Demographic and clinical data were recorded. On transesophageal echocardiography, descending and aortic arch atherosclerosis were recorded (in millimeters) using off-line planimetry. The patients were graded with normal AA (group 1, n = 83), mild AA (≤4 mm in thickness, group 2, n = 53), or severe AA (>4 mm in thickness or complex, group 3, n = 64). Glomerular filtration rate (GFR) (expressed as milliliters/minute/1.73 meters squared) was calculated as 186 × (serum creatinine-1.154) × (age-0.203) × 1.212 (if black) × 0.742 (if female). Results: The mean GFR decreased significantly with increasing severity of AA (89 ± 20 for group 1, 72 ± 20 for group 2, and 49 ± 23 for group 3, P <.001). Seventy-three percent of patients with severe atherosclerosis compared with 16% patients with no or mild AA had moderate-severe renal dysfunction (GFR <60; P <.001). On multiple logistic regression, only the size of the AA and the presence of diabetes mellitus were associated with severe (GFR <30) renal dysfunction (P <.001, odds ratio 65). On receiver operating curve analysis, the area under the curve for AA predicting severe renal dysfunction was 0.90 (P <.0001). Conclusion: There exists a strong association between AA and renal dysfunction.
Original language | English (US) |
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Pages (from-to) | 751-755 |
Number of pages | 5 |
Journal | Journal of the American Society of Echocardiography |
Volume | 21 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2008 |
Externally published | Yes |
Keywords
- Aortic atherosclerosis
- Renal dysfunction
- Transesophageal echocardiography
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine