Association of antenatal steroid use with cord blood immune biomarkers in preterm births

Praveen Kumar; Scott A. Venners; Lingling Fu; Colleen Pearson; Katherin Ortiz; Xiaobin Wang

doi:10.1016/j.earlhumdev.2011.04.013

Association of antenatal steroid use with cord blood immune biomarkers in preterm births

Praveen Kumar, Scott A. Venners, Lingling Fu, Colleen Pearson, Katherin Ortiz, Xiaobin Wang

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

To evaluate the effect of maternal administration of antenatal steroids (ANS) on cord blood cytokine levels at birth in preterm infants. Methods: Cord blood cytokine concentrations were measured for pro-inflammatory cytokines (IL-1β, IL-6, and IL-8); anti-inflammatory cytokines (IL-4, IL-10 and TGF-β); and neurotrophic cytokines (BDNF, NT-3, and NT-4) in two hundred preterm infants. Data were analyzed using multivariable linear regression to model the independent and joint effects of ANS and inflammation on mean log cord blood cytokine concentrations adjusted for gestational age and Apgar scores. Results: Exposure to ANS had no significant effect on the cord blood concentrations of cytokines measured in this study. All three pro-inflammatory cytokine levels and levels of IL-10 were significantly increased and cord blood levels of TGF-β and NT-3 were significantly decreased in infants with placental inflammation. Conclusion: Although exposure to ANS did not have any significant effect on cord blood levels of cytokines, there was a trend toward the attenuation of inflammatory response and higher levels of neurotrophic cytokines in infants born to mothers with placental inflammation and exposure to ANS compared to infants born to mothers with placental inflammation and no ANS exposure.

Original language	English (US)
Pages (from-to)	559-564
Number of pages	6
Journal	Early Human Development
Volume	87
Issue number	8
DOIs	https://doi.org/10.1016/j.earlhumdev.2011.04.013
State	Published - Aug 2011
Externally published	Yes

Keywords

Antenatal steroids
Brain-derived neurotrophic factor
Cord blood cytokines
Nerve growth factor
Neurotrophin

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1016/j.earlhumdev.2011.04.013

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title = "Association of antenatal steroid use with cord blood immune biomarkers in preterm births",

abstract = "To evaluate the effect of maternal administration of antenatal steroids (ANS) on cord blood cytokine levels at birth in preterm infants. Methods: Cord blood cytokine concentrations were measured for pro-inflammatory cytokines (IL-1β, IL-6, and IL-8); anti-inflammatory cytokines (IL-4, IL-10 and TGF-β); and neurotrophic cytokines (BDNF, NT-3, and NT-4) in two hundred preterm infants. Data were analyzed using multivariable linear regression to model the independent and joint effects of ANS and inflammation on mean log cord blood cytokine concentrations adjusted for gestational age and Apgar scores. Results: Exposure to ANS had no significant effect on the cord blood concentrations of cytokines measured in this study. All three pro-inflammatory cytokine levels and levels of IL-10 were significantly increased and cord blood levels of TGF-β and NT-3 were significantly decreased in infants with placental inflammation. Conclusion: Although exposure to ANS did not have any significant effect on cord blood levels of cytokines, there was a trend toward the attenuation of inflammatory response and higher levels of neurotrophic cytokines in infants born to mothers with placental inflammation and exposure to ANS compared to infants born to mothers with placental inflammation and no ANS exposure.",

keywords = "Antenatal steroids, Brain-derived neurotrophic factor, Cord blood cytokines, Nerve growth factor, Neurotrophin",

author = "Praveen Kumar and Venners, {Scott A.} and Lingling Fu and Colleen Pearson and Katherin Ortiz and Xiaobin Wang",

note = "Funding Information: The parent study received funding from the National Institute of Child Health and Human Development ( R01 HD41702 ), the National Institute of Environmental Health Sciences ( R21ES11666 ), and the March of Dimes Birth Defects Foundation ( 20-FY98-0701 and 20-FY02-56 ).",

year = "2011",

month = aug,

doi = "10.1016/j.earlhumdev.2011.04.013",

language = "English (US)",

volume = "87",

pages = "559--564",

journal = "Early Human Development",

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publisher = "Elsevier Ireland Ltd",

number = "8",

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T1 - Association of antenatal steroid use with cord blood immune biomarkers in preterm births

AU - Kumar, Praveen

AU - Venners, Scott A.

AU - Fu, Lingling

AU - Pearson, Colleen

AU - Ortiz, Katherin

AU - Wang, Xiaobin

N1 - Funding Information: The parent study received funding from the National Institute of Child Health and Human Development ( R01 HD41702 ), the National Institute of Environmental Health Sciences ( R21ES11666 ), and the March of Dimes Birth Defects Foundation ( 20-FY98-0701 and 20-FY02-56 ).

PY - 2011/8

Y1 - 2011/8

N2 - To evaluate the effect of maternal administration of antenatal steroids (ANS) on cord blood cytokine levels at birth in preterm infants. Methods: Cord blood cytokine concentrations were measured for pro-inflammatory cytokines (IL-1β, IL-6, and IL-8); anti-inflammatory cytokines (IL-4, IL-10 and TGF-β); and neurotrophic cytokines (BDNF, NT-3, and NT-4) in two hundred preterm infants. Data were analyzed using multivariable linear regression to model the independent and joint effects of ANS and inflammation on mean log cord blood cytokine concentrations adjusted for gestational age and Apgar scores. Results: Exposure to ANS had no significant effect on the cord blood concentrations of cytokines measured in this study. All three pro-inflammatory cytokine levels and levels of IL-10 were significantly increased and cord blood levels of TGF-β and NT-3 were significantly decreased in infants with placental inflammation. Conclusion: Although exposure to ANS did not have any significant effect on cord blood levels of cytokines, there was a trend toward the attenuation of inflammatory response and higher levels of neurotrophic cytokines in infants born to mothers with placental inflammation and exposure to ANS compared to infants born to mothers with placental inflammation and no ANS exposure.

AB - To evaluate the effect of maternal administration of antenatal steroids (ANS) on cord blood cytokine levels at birth in preterm infants. Methods: Cord blood cytokine concentrations were measured for pro-inflammatory cytokines (IL-1β, IL-6, and IL-8); anti-inflammatory cytokines (IL-4, IL-10 and TGF-β); and neurotrophic cytokines (BDNF, NT-3, and NT-4) in two hundred preterm infants. Data were analyzed using multivariable linear regression to model the independent and joint effects of ANS and inflammation on mean log cord blood cytokine concentrations adjusted for gestational age and Apgar scores. Results: Exposure to ANS had no significant effect on the cord blood concentrations of cytokines measured in this study. All three pro-inflammatory cytokine levels and levels of IL-10 were significantly increased and cord blood levels of TGF-β and NT-3 were significantly decreased in infants with placental inflammation. Conclusion: Although exposure to ANS did not have any significant effect on cord blood levels of cytokines, there was a trend toward the attenuation of inflammatory response and higher levels of neurotrophic cytokines in infants born to mothers with placental inflammation and exposure to ANS compared to infants born to mothers with placental inflammation and no ANS exposure.

KW - Antenatal steroids

KW - Brain-derived neurotrophic factor

KW - Cord blood cytokines

KW - Nerve growth factor

KW - Neurotrophin

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Association of antenatal steroid use with cord blood immune biomarkers in preterm births

Abstract

Keywords

ASJC Scopus subject areas

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