Association of anemia with outcomes in men with moderate and severe chronic kidney disease

C. P. Kovesdy, B. K. Trivedi, K. Kalantar-Zadeh, J. E. Anderson

Research output: Contribution to journalArticle

Abstract

Anemia is a common complication of chronic kidney disease (CKD), but the outcomes associated with lower hemoglobin (Hgb) levels in patients with CKD not yet on dialysis are not well characterized. Analyses exploring outcomes associated with a single baseline Hgb value also do not account for the longitudinal variation of this measure. After collecting all Hgb measurements (N= 17 194, median (range): 12 (1-168)) over a median follow-up period of 2.1 years in a historical prospective cohort of 853 male US veterans with CKD Stages 3-5 not yet on dialysis, we examined the association of time-averaged Hgb levels with predialysis all-cause mortality, end-stage renal disease (ESRD), and a composite end point of both. Kaplan-Meier survival analysis and Cox models adjusted for age, race, body mass index, smoking status, blood pressure, diabetes mellitus, cardiovascular disease, categories of estimated glomerular filtration rate, serum concentrations of albumin and cholesterol, and proteinuria were examined. Lower time-averaged Hgb was associated with significantly higher hazard of the composite end point (hazard ratio (95% confidence interval) in the adjusted model for time-averaged Hgb of 130g/l: 2.57 (1.85-3.58), 1.97 (1.45-2.66), 1.19 (0.86-1.63), Ptrend <0.001). Lower time-averaged Hgb was associated with both significantly higher pre-dialysis mortality and higher risk of ESRD, when analyzed separately. Anemia (especially time-averaged Hgb

Original languageEnglish (US)
Pages (from-to)560-564
Number of pages5
JournalKidney International
Volume69
Issue number3
DOIs
StatePublished - Feb 2006

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Chronic Renal Insufficiency
Anemia
Hemoglobins
Dialysis
Chronic Kidney Failure
Mortality
Kaplan-Meier Estimate
Veterans
Survival Analysis
Glomerular Filtration Rate
Proteinuria
Proportional Hazards Models
Serum Albumin
Diabetes Mellitus
Body Mass Index
Cardiovascular Diseases
Smoking
Cholesterol
Confidence Intervals
Blood Pressure

Keywords

  • Anemia
  • Chronic kidney disease
  • End-stage renal disease
  • Mortality

ASJC Scopus subject areas

  • Nephrology

Cite this

Kovesdy, C. P., Trivedi, B. K., Kalantar-Zadeh, K., & Anderson, J. E. (2006). Association of anemia with outcomes in men with moderate and severe chronic kidney disease. Kidney International, 69(3), 560-564. https://doi.org/10.1038/sj.ki.5000105

Association of anemia with outcomes in men with moderate and severe chronic kidney disease. / Kovesdy, C. P.; Trivedi, B. K.; Kalantar-Zadeh, K.; Anderson, J. E.

In: Kidney International, Vol. 69, No. 3, 02.2006, p. 560-564.

Research output: Contribution to journalArticle

Kovesdy, CP, Trivedi, BK, Kalantar-Zadeh, K & Anderson, JE 2006, 'Association of anemia with outcomes in men with moderate and severe chronic kidney disease', Kidney International, vol. 69, no. 3, pp. 560-564. https://doi.org/10.1038/sj.ki.5000105
Kovesdy, C. P. ; Trivedi, B. K. ; Kalantar-Zadeh, K. ; Anderson, J. E. / Association of anemia with outcomes in men with moderate and severe chronic kidney disease. In: Kidney International. 2006 ; Vol. 69, No. 3. pp. 560-564.
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