Association of an intensive lifestyle intervention with remission of type 2 diabetes

Edward W. Gregg, Haiying Chen, Lynne E. Wagenknecht, Jeanne Clark, Linda M. Delahanty, John Bantle, Henry J. Pownall, Karen C. Johnson, Monika M. Safford, Abbas E. Kitabchi, F. Xavier Pi-Sunyer, Rena R. Wing, Alain G. Bertoni

Research output: Contribution to journalArticle

Abstract

Context: The frequency of remission of type 2 diabetes achievable with lifestyle intervention is unclear. Objective: To examine the association of a long-term intensive weight-loss intervention with the frequency of remission from type 2 diabetes to prediabetes or normoglycemia. Design, Setting, and Participants: Ancillary observational analysis of a 4-year randomized controlled trial (baseline visit, August 2001-April 2004; last follow-up, April 2008) comparing an intensive lifestyle intervention (ILI) with a diabetes support and education control condition (DSE) among 4503 US adults with body mass index of 25 or higher and type 2 diabetes. Interventions: Participants were randomly assigned to receive the ILI, which included weekly group and individual counseling in the first 6 months followed by 3 sessions per month for the second 6 months and twice-monthly contact and regular refresher group series and campaigns in years 2 to 4 (n=2241) or the DSE, which was an offer of 3 group sessions per year on diet, physical activity, and social support (n=2262). Main Outcome Measures: Partial or complete remission of diabetes, defined as transition from meeting diabetes criteria to a prediabetes or nondiabetic level of glycemia (fasting plasma glucose 1c

Original languageEnglish (US)
Pages (from-to)2489-2496
Number of pages8
JournalJournal of the American Medical Association
Volume308
Issue number23
DOIs
StatePublished - Dec 19 2012

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Type 2 Diabetes Mellitus
Life Style
Prediabetic State
Social Support
Counseling
Weight Loss
Fasting
Body Mass Index
Randomized Controlled Trials
Outcome Assessment (Health Care)
Diet
Education
Glucose

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gregg, E. W., Chen, H., Wagenknecht, L. E., Clark, J., Delahanty, L. M., Bantle, J., ... Bertoni, A. G. (2012). Association of an intensive lifestyle intervention with remission of type 2 diabetes. Journal of the American Medical Association, 308(23), 2489-2496. https://doi.org/10.1001/jama.2012.67929

Association of an intensive lifestyle intervention with remission of type 2 diabetes. / Gregg, Edward W.; Chen, Haiying; Wagenknecht, Lynne E.; Clark, Jeanne; Delahanty, Linda M.; Bantle, John; Pownall, Henry J.; Johnson, Karen C.; Safford, Monika M.; Kitabchi, Abbas E.; Pi-Sunyer, F. Xavier; Wing, Rena R.; Bertoni, Alain G.

In: Journal of the American Medical Association, Vol. 308, No. 23, 19.12.2012, p. 2489-2496.

Research output: Contribution to journalArticle

Gregg, EW, Chen, H, Wagenknecht, LE, Clark, J, Delahanty, LM, Bantle, J, Pownall, HJ, Johnson, KC, Safford, MM, Kitabchi, AE, Pi-Sunyer, FX, Wing, RR & Bertoni, AG 2012, 'Association of an intensive lifestyle intervention with remission of type 2 diabetes', Journal of the American Medical Association, vol. 308, no. 23, pp. 2489-2496. https://doi.org/10.1001/jama.2012.67929
Gregg, Edward W. ; Chen, Haiying ; Wagenknecht, Lynne E. ; Clark, Jeanne ; Delahanty, Linda M. ; Bantle, John ; Pownall, Henry J. ; Johnson, Karen C. ; Safford, Monika M. ; Kitabchi, Abbas E. ; Pi-Sunyer, F. Xavier ; Wing, Rena R. ; Bertoni, Alain G. / Association of an intensive lifestyle intervention with remission of type 2 diabetes. In: Journal of the American Medical Association. 2012 ; Vol. 308, No. 23. pp. 2489-2496.
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