Association of activated vitamin D treatment and mortality in chronic kidney disease

Csaba P. Kovesdy, Shahram Ahmadzadeh, John E. Anderson, Kamyar Kalantar-Zadeh

Research output: Contribution to journalArticle

Abstract

Background: Treatment of secondary hyperparathyroidism (SHPT) with activated vitamin D analogues is associated with better survival in patients receiving dialysis. It is unclear whether such a benefit is present in patients with predialysis chronic kidney disease (CKD). Methods: We examined the association of oral calcitriol treatment with mortality and the incidence of dialysis in 520 male US veterans (mean [SD] age, 69.8 [10.3] years; 23.5% black) with CKD stages 3 to 5 and not yet receiving dialysis (mean [SD] estimated glomerular filtration rate, 30.8 [11.3]). Associations were examined by the Kaplan-Meier method and in Poisson regression models with adjustment for age, race, comorbidities, smoking, blood pressure, body mass index, use of phosphate binders, estimated glomerular filtration rate, proteinuria, white blood cell count, percentage of lymphocytes, and levels of parathyroid hormone, calcium, phosphorus, albumin, bicarbonate, and hemoglobin. Results: Two hundred fifty-eight of 520 subjects received treatment with calcitriol, 0.25 to 0.5 μg/d, for a median duration of 2.1 years (range, 0.06-6.0 years). The incidence rate ratios for mortality and combined death and dialysis initiation were significantly lower in treated vs untreated patients (P

Original languageEnglish (US)
Pages (from-to)397-403
Number of pages7
JournalArchives of Internal Medicine
Volume168
Issue number4
DOIs
StatePublished - Feb 25 2008

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Chronic Renal Insufficiency
Vitamin D
Dialysis
Mortality
Calcitriol
Glomerular Filtration Rate
Secondary Hyperparathyroidism
Incidence
Veterans
Therapeutics
Bicarbonates
Parathyroid Hormone
Leukocyte Count
Proteinuria
Phosphorus
Comorbidity
Albumins
Hemoglobins
Body Mass Index
Smoking

ASJC Scopus subject areas

  • Internal Medicine

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Association of activated vitamin D treatment and mortality in chronic kidney disease. / Kovesdy, Csaba P.; Ahmadzadeh, Shahram; Anderson, John E.; Kalantar-Zadeh, Kamyar.

In: Archives of Internal Medicine, Vol. 168, No. 4, 25.02.2008, p. 397-403.

Research output: Contribution to journalArticle

Kovesdy, Csaba P. ; Ahmadzadeh, Shahram ; Anderson, John E. ; Kalantar-Zadeh, Kamyar. / Association of activated vitamin D treatment and mortality in chronic kidney disease. In: Archives of Internal Medicine. 2008 ; Vol. 168, No. 4. pp. 397-403.
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