TY - JOUR
T1 - Association of abdominal fat with serum amylase in an older cohort
T2 - The Baltimore Longitudinal Study of Aging
AU - Dias, Jenny Pena
AU - Schrack, Jennifer A.
AU - Shardell, Michelle D.
AU - Egan, Josephine M.
AU - Studenski, Stephanie
N1 - Funding Information:
The BLSA is a study of normative human aging, established in 1958 and supported by the National Institute on Aging Intramural Research Program (NIA – IRP). General descriptions of the sample and the enrollment procedures and criteria have been reported [15] . Briefly, the BLSA constitutes a continuously enrolled cohort with some targeted recruitment (e.g., women, racial minorities) over its 57-plus year history. All participants are community volunteers who must pass a comprehensive health and functional screening evaluation and be free of all major chronic conditions and cognitive and functional impairment at enrollment. Once enrolled, participants undergo extensive testing every one to four years depending on their age and are followed for life. The population for the current study consists of 778 participants seen in the BLSA clinic between April 2003 and June 2012. The NIH NIEHS IRB (National Institute of Environmental Health Sciences) approved the study protocol and all participants provided written informed consent.
Funding Information:
This research was supported by the Intramural Research Program of the National Institute of Health (NIH) , National Institute on Aging (NIA), United States .
Publisher Copyright:
© 2016.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Aims: Abdominal fat is a major determinant of metabolic diseases in older individuals. Obesity and diabetes are associated with low serum amylase (SA) levels, but the association between SA and metabolic disease is poorly understood. We investigated the association of low SA with diabetes and sex-specific associations of serum amylase with abdominal fat in older adults. Methods: In community-dwelling volunteers from the Baltimore Longitudinal Study of Aging (778 participants, age 66.8 ± 13.6 years), we assessed abdominal fat by computed tomography and diabetes status using the American Diabetes Association criteria. Linear regression analyses assessed the cross-sectional associations between abdominal fat and SA, and logistic regression assessed the odds of diabetes, given low SA. Results: In unadjusted analyses, individuals in the lowest SA quartile (<48 μ/L) had 1.97 greater odds of diabetes, (95%CI, 1.01-3.83) than those in the highest quartile (≥80 μ/L). This association was no longer significant after adjusting for visceral adipose tissue area (VAT, dm2), abdominal subcutaneous adipose tissue (SAT, dm2) or BMI. In adjusted analyses, VAT and SAT were significantly associated with SA in both sexes. Among women, SA was more strongly associated with VAT than with SAT or BMI; VAT (β = -0.117 ± 0.048, P < 0.001), SAT (β = -0.023 ± 0.025, P = 0.346) and BMI (β = -0.0052 ± 0.075, P = 0.49). Conclusions: The association between SA and diabetes was explained mainly by abdominal visceral fat. In women, SA was more strongly associated with VAT than with BMI or SAT. These findings provide motivation for future mechanistic studies on SA's role in metabolic diseases.
AB - Aims: Abdominal fat is a major determinant of metabolic diseases in older individuals. Obesity and diabetes are associated with low serum amylase (SA) levels, but the association between SA and metabolic disease is poorly understood. We investigated the association of low SA with diabetes and sex-specific associations of serum amylase with abdominal fat in older adults. Methods: In community-dwelling volunteers from the Baltimore Longitudinal Study of Aging (778 participants, age 66.8 ± 13.6 years), we assessed abdominal fat by computed tomography and diabetes status using the American Diabetes Association criteria. Linear regression analyses assessed the cross-sectional associations between abdominal fat and SA, and logistic regression assessed the odds of diabetes, given low SA. Results: In unadjusted analyses, individuals in the lowest SA quartile (<48 μ/L) had 1.97 greater odds of diabetes, (95%CI, 1.01-3.83) than those in the highest quartile (≥80 μ/L). This association was no longer significant after adjusting for visceral adipose tissue area (VAT, dm2), abdominal subcutaneous adipose tissue (SAT, dm2) or BMI. In adjusted analyses, VAT and SAT were significantly associated with SA in both sexes. Among women, SA was more strongly associated with VAT than with SAT or BMI; VAT (β = -0.117 ± 0.048, P < 0.001), SAT (β = -0.023 ± 0.025, P = 0.346) and BMI (β = -0.0052 ± 0.075, P = 0.49). Conclusions: The association between SA and diabetes was explained mainly by abdominal visceral fat. In women, SA was more strongly associated with VAT than with BMI or SAT. These findings provide motivation for future mechanistic studies on SA's role in metabolic diseases.
KW - Abdominal visceral/subcutaneous fat
KW - Aging
KW - Diabetes
KW - Serum amylase
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U2 - 10.1016/j.diabres.2016.04.015
DO - 10.1016/j.diabres.2016.04.015
M3 - Article
C2 - 27321338
AN - SCOPUS:84965032125
SN - 0168-8227
VL - 116
SP - 212
EP - 217
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
ER -