Association of a modified physiologic index with mortality and incident disability

The health, aging, and body composition study

Jason L. Sanders, Robert M. Boudreau, Brenda W. Penninx, Eleanor Marie Simonsick, Stephen B. Kritchevsky, Suzanne Satterfield, Tamara B. Harris, Douglas C. Bauer, Anne B. Newman

Research output: Contribution to journalArticle

Abstract

Background.Indexes constructed from components may identify individuals who age well across systems. We studied the associations of a Modified Physiologic Index (systolic blood pressure, forced vital capacity, Digit Symbol Substitution Test score, serum cystatin-C, serum fasting glucose) with mortality and incident disability.Methods.Data are from the Health, Aging, and Body Composition study on 2,737 persons (51.2% women, 40.3% black) aged 70-79 years at baseline and followed on average 9.3 (2.9) years. Components were graded 0 (healthiest), 1 (middle), or 2 (unhealthiest) by tertile or clinical cutpoints and summed to calculate a continuous index score (range 0-10). We used multivariate Cox proportional hazards regression to calculate risk of death or disability and determined accuracy predicting death using the area under the curve.Results.Mortality was 19% greater per index unit (p

Original languageEnglish (US)
Pages (from-to)1439-1446
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume67
Issue number12
DOIs
StatePublished - Dec 2012

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Body Composition
Blood Pressure
Cystatin C
Mortality
Vital Capacity
Health
Serum
Area Under Curve
Fasting
Glucose

Keywords

  • Aging
  • Disability
  • Index
  • Longevity
  • Mortality

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Association of a modified physiologic index with mortality and incident disability : The health, aging, and body composition study. / Sanders, Jason L.; Boudreau, Robert M.; Penninx, Brenda W.; Simonsick, Eleanor Marie; Kritchevsky, Stephen B.; Satterfield, Suzanne; Harris, Tamara B.; Bauer, Douglas C.; Newman, Anne B.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 67, No. 12, 12.2012, p. 1439-1446.

Research output: Contribution to journalArticle

Sanders, Jason L. ; Boudreau, Robert M. ; Penninx, Brenda W. ; Simonsick, Eleanor Marie ; Kritchevsky, Stephen B. ; Satterfield, Suzanne ; Harris, Tamara B. ; Bauer, Douglas C. ; Newman, Anne B. / Association of a modified physiologic index with mortality and incident disability : The health, aging, and body composition study. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2012 ; Vol. 67, No. 12. pp. 1439-1446.
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