Association of a Germ-Line copy number variation at 2p24.3 and risk for aggressive prostate cancer

Wennuan Liu, Jishan Sun, Ge Li, Yi Zhu, Scott Zhang, Seong Tae Kim, Jielin Sun, Fredrik Wiklund, Kathleen Wiley, Sarah D. Isaacs, Par Stattin, Jianfeng Xu, David Duggan, John D. Carpten, William B. Isaacs, Henrik Grönberg, S. Lilly Zheng, Bao Li Chang

Research output: Contribution to journalArticle

Abstract

We searched for deletions in the germ-line genome among 498 aggressive prostate cancer cases and 494 controls from a population-based study in Sweden [G4neer of the Prostate in Sweden (CAPS)] using Affymetrix SNI' arrays. By comparing allele intensities of ~ 500,000 SNP probes across the genome, a germ-line deletion at 2p24.3 was observed to be significantly more common in cases (12.63%) than in controls (8.28%); P = 0.028. To confirm the association, we genotyped this germ-line copy number variation (CNV) in additional subjects from CAPS and from Johns Hopkins Hospital (JHH). Overall, among 4,314 cases and 2,176 controls examined, the CNV was significantly associated with prostate cancer risk [odds ratio (OR), 1.25; 95% confidence interval (95% CI), 1.06-1.48; P = 0.009]. More importantly, the association was stronger for aggressive prostate cancer (OR, 1.31; 95% CI, 1.08-1.58; P = 0.006) than for nonaggressive prostate cancer (OR, 1.19; 95% CI, 0.98-1.45; P = 0.08). The biological effect of this germ-line CNV is unknown because no known gene resides in the deletion. Results from this study represent the first novel germ-line CNV that was identified from a genome-wide search and was significantly, but moderately, associated with prostate cancer risk. Additional confirmation of this association and functional studies are warranted.

Original languageEnglish (US)
Pages (from-to)2176-2179
Number of pages4
JournalCancer Research
Volume69
Issue number6
DOIs
StatePublished - Mar 15 2009

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Association of a Germ-Line copy number variation at 2p24.3 and risk for aggressive prostate cancer'. Together they form a unique fingerprint.

  • Cite this

    Liu, W., Sun, J., Li, G., Zhu, Y., Zhang, S., Kim, S. T., Sun, J., Wiklund, F., Wiley, K., Isaacs, S. D., Stattin, P., Xu, J., Duggan, D., Carpten, J. D., Isaacs, W. B., Grönberg, H., Zheng, S. L., & Chang, B. L. (2009). Association of a Germ-Line copy number variation at 2p24.3 and risk for aggressive prostate cancer. Cancer Research, 69(6), 2176-2179. https://doi.org/10.1158/0008-5472.CAN-08-3151