Association Between Vancomycin Trough Concentrations and Duration of Methicillin-Resistant Staphylococcus aureus Bacteremia in Children

Alice J. Hsu; Rana F. Hamdy; Yanjie Huang; Jared A. Olson; Shahira Ghobrial; Jeffrey S. Gerber; Adam L. Hersh; Pranita D. Tamma

doi:10.1093/jpids/pix068

Association Between Vancomycin Trough Concentrations and Duration of Methicillin-Resistant Staphylococcus aureus Bacteremia in Children

Alice J. Hsu, Rana F. Hamdy, Yanjie Huang, Jared A. Olson, Shahira Ghobrial, Jeffrey S. Gerber, Adam L. Hersh, Pranita D. Tamma

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

In a multicenter retrospective study, we sought to determine the optimal vancomycin trough concentration that would impact the duration of methicillin-resistant Staphylococcus aureus bacteremia in children. We found that a median vancomycin trough concentration of <10 µg/mL within the first 72 hours may be associated with a longer duration of bacteremia compared to a median trough concentration of ≥10 µg/mL.

Original language	English (US)
Pages (from-to)	338-341
Number of pages	4
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	7
Issue number	4
DOIs	https://doi.org/10.1093/jpids/pix068
State	Published - Dec 3 2018

ASJC Scopus subject areas

General Medicine

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title = "Association Between Vancomycin Trough Concentrations and Duration of Methicillin-Resistant Staphylococcus aureus Bacteremia in Children",

abstract = "In a multicenter retrospective study, we sought to determine the optimal vancomycin trough concentration that would impact the duration of methicillin-resistant Staphylococcus aureus bacteremia in children. We found that a median vancomycin trough concentration of <10 µg/mL within the first 72 hours may be associated with a longer duration of bacteremia compared to a median trough concentration of ≥10 µg/mL.",

author = "Hsu, {Alice J.} and Hamdy, {Rana F.} and Yanjie Huang and Olson, {Jared A.} and Shahira Ghobrial and Gerber, {Jeffrey S.} and Hersh, {Adam L.} and Tamma, {Pranita D.}",

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AU - Hsu, Alice J.

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AU - Huang, Yanjie

AU - Olson, Jared A.

AU - Ghobrial, Shahira

AU - Gerber, Jeffrey S.

AU - Hersh, Adam L.

AU - Tamma, Pranita D.

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AB - In a multicenter retrospective study, we sought to determine the optimal vancomycin trough concentration that would impact the duration of methicillin-resistant Staphylococcus aureus bacteremia in children. We found that a median vancomycin trough concentration of <10 µg/mL within the first 72 hours may be associated with a longer duration of bacteremia compared to a median trough concentration of ≥10 µg/mL.

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Association Between Vancomycin Trough Concentrations and Duration of Methicillin-Resistant Staphylococcus aureus Bacteremia in Children

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